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PFKFB3 (human)

Overview PFKFB3 Synthesis and degradation of fructose 2,6-bisphosphate. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Motility/polarity/chemotaxis; Kinase, other Cellular Component: cytosol Molecular Function: fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; ATP binding Biological Process: glycolysis; carbohydrate metabolic process; glucose metabolic process; fructose 2,6-bisphosphate metabolic process; fructose metabolic process Reference #:  Q16875 (UniProtKB) Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; F263; FLJ37326; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY-REN-56 Gene Symbols: PFKFB3 Molecular weight: 59,609 Da Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PFKFB3 2AXN - A=1-520 (human) 2DWO - A=1-520 (human) 2DWP - A=1-520 (human) 2I1V - B=1-520 (human) 3QPU - A=1-520 (human) 3QPV - A=1-520 (human) 3QPW - A=1-520 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW  |  ENZYME 2.7.1.105 3.1.3.46  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S461‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		K111-u	LAALRDVkSYLAkEG
0	1		K116-u	DVkSYLAkEGGQIAV
0	6		Y194-p	FMKRISCyEASYQPL
0	1		K214-u	DRDLSLIkVIDVGRR
0	1		S273-p	GGDSGLSsRGKkFAS
0	1		K277-u	GLSsRGKkFASALsK
0	1		S283-p	KkFASALsKFVEEQN
0	2		K292-u	FVEEQNLkDLRVWTS
0	35		K302-u	RVWTSQLkSTIQTAE
0	1		Y363-p	RYPTGESyQDLVQRL
4	89		S461-p	NPLMRRNsVtPLAsP
0	6		T463-p	LMRRNsVtPLAsPEP
0	34		S467-p	NsVtPLAsPEPtKKP
0	1		T471-p	PLAsPEPtKKPRINs
0	6		S478-p	tKKPRINsFEEHVAS

	mouse
K111	LAALRDVKSYLTKEG
K116	DVKSYLTKEGGQIAV
Y194-p	FMKRINCyEASYQPL
K214	DRDLSLIKVIDVGRR
S273	GGDSSLSSRGKKFAN
K277	SLSSRGKKFANALSK
S283	KKFANALSKFVEEQN
K292-u	FVEEQNLkDLRVWTS
K302-u	RVWTSQLkSTIQTAE
Y363	RYPTGESYQDLVQRL
S461-p	NPLMRRNsVtPLAsP
T463-p	LMRRNsVtPLAsPEP
S467-p	NsVtPLAsPEPTKKP
T471	PLAsPEPTKKPRINs
S478-p	TKKPRINsFEERVAS

	rat
K111	LAALRDVKSYLTKEG
K116	DVKSYLTKEGGQIAV
Y194	FMKRINCYEASYQPL
K214	DRDLSFIKVIDVGRR
S273	GGDSGLSSRGKKFAN
K277	GLSSRGKKFANALSK
S283	KKFANALSKFVEEQN
K292	FVEEQNLKDLRVWTS
K302	RVWTSQLKSTIQTAE
Y363	RYPTGESYQDLVQRL
S490-p	NPLMRRNsVTPLASP
T492	LMRRNsVTPLASPEP
S496	NsVTPLASPEPTKKP
T500	PLASPEPTKKPRINS
S507	TKKPRINSFEEHVAS

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