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Protein Page:
PFKFB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PFKFB3 Synthesis and degradation of fructose 2,6-bisphosphate. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.105; Carbohydrate Metabolism - fructose and mannose; Kinase, other; EC 3.1.3.46; Phosphatase (non-protein); Motility/polarity/chemotaxis
Cellular Component: nucleolus; cytosol; nucleus
Molecular Function: fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; ATP binding
Biological Process: glycolysis; dephosphorylation; carbohydrate metabolic process; carbohydrate phosphorylation; glucose metabolic process; fructose 2,6-bisphosphate metabolic process; fructose metabolic process
Reference #:  Q16875 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; F263; FLJ37326; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY-REN-56
Gene Symbols: PFKFB3
Molecular weight: 59,609 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PFKFB3

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S461‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S22 VPVDHRPSLPRSCGP
0 4 K111-ub LAALRDVkSYLAkEG
0 1 K116-ub DVkSYLAkEGGQIAV
0 1 S172-p IMEVKISsPDYKDCN
0 6 Y194-p FMKRISCyEASYQPL
0 1 K214-ub DRDLSLIkVIDVGRR
0 1 S273-p GGDSGLSsRGKkFAS
0 1 K277-ub GLSsRGKkFASALsK
0 1 S283-p KkFASALsKFVEEQN
0 2 K292-ub FVEEQNLkDLRVWTS
0 35 K302-ub RVWTSQLkSTIQTAE
5 107 S461-p NPLMRRNsVtPLAsP
0 8 T463-p LMRRNsVtPLAsPEP
0 43 S467-p NsVtPLAsPEPtKKP
0 2 T471-p PLAsPEPtKKPRINs
1 9 S478-p tKKPRINsFEEHVAS
0 1 S485 sFEEHVASTSAALPS
0 1 T486 FEEHVASTSAALPSC
0 1 S487 EEHVASTSAALPSCL
0 1 S510 PGQNMKGSRSSADSS
0 1 S512 QNMKGSRSSADSSRK
0 1 S516 GSRSSADSSRKH___
0 1 S517 SRSSADSSRKH____
  mouse

 
S22-p VPVDHRPsLPRSCGP
K111 LAALRDVKSYLTKEG
K116 DVKSYLTKEGGQIAV
S172 IMEVKISSPDYKDCN
Y194-p FMKRINCyEASYQPL
K214 DRDLSLIKVIDVGRR
S273 GGDSSLSSRGKKFAN
K277 SLSSRGKKFANALSK
S283 KKFANALSKFVEEQN
K292-ub FVEEQNLkDLRVWTS
K302-ub RVWTSQLkSTIQTAE
S461-p NPLMRRNsVtPLAsP
T463-p LMRRNsVtPLAsPEP
S467-p NsVtPLAsPEPTKKP
T471 PLAsPEPTKKPRINs
S478-p TKKPRINsFEERVAs
S485-p sFEERVAstsAALPS
T486-p FEERVAstsAALPSC
S487-p EERVAstsAALPSCL
S510-p PGQNMKSsRsGADss
S512-p QNMKSsRsGADssQK
S516-p SsRsGADssQKH___
S517-p sRsGADssQKH____
  rat

 
S22 VPVDHRPSLPRSCGP
K111 LAALRDVKSYLTKEG
K116 DVKSYLTKEGGQIAV
S172 IMEVKISSPDYKDCN
Y194 FMKRINCYEASYQPL
K214 DRDLSFIKVIDVGRR
S273 GGDSGLSSRGKKFAN
K277 GLSSRGKKFANALSK
S283 KKFANALSKFVEEQN
K292 FVEEQNLKDLRVWTS
K302 RVWTSQLKSTIQTAE
S490-p NPLMRRNsVTPLASP
T492 LMRRNsVTPLASPEP
S496 NsVTPLASPEPTKKP
T500 PLASPEPTKKPRINS
S507 TKKPRINSFEEHVAS
S514 SFEEHVASTSAALPS
T515 FEEHVASTSAALPSC
S516 EEHVASTSAALPSCL
- gap
- gap
- gap
- gap
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