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Protein Page:
CNOT6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CNOT6 Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase
Cellular Component: cytosol; nucleus; CCR4-NOT complex
Molecular Function: protein binding; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding
Biological Process: regulation of translation; poly(A) tail shortening; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA metabolic process; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay
Reference #:  Q9ULM6 (UniProtKB)
Alt. Names/Synonyms: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase; KIAA1194
Gene Symbols: CNOT6
Molecular weight: 63,307 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CNOT6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T146 LYQEPDGTRRLLNYL
0 1 K162-u DNLSGTAkRITTEQP
  mouse

 
T146-p LCLEPDGtRRLLNYL
K162 DNLSGTAKRISTEQP
  rat

 
T146 LCLEPDGTRRLLNYL
K162 DNLSGTAKRISTEQP
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