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LATS1 (human)

Overview LATS1 an AGC kinase of the NDR family of kinases. Localized to the mitotic apparatus and specifically phosphorylated during mitosis. A likely tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity, causing G2 arrest. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. Complexes with CDC2 in early mitosis. LATS1-associated CDC2 has no mitotic cyclin partner and no apparent kinase activity. Binds phosphorylated zyxin, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. Knockout mice are susceptible to soft-tissue sarcomas and sensitive to chemical carcinogenesis. Human soft tissue sarcomas have downregulated, mutated, and/or hypermethylated LATS1. Transgenic expression blocks anchorage independent growth in culture and tumor growth in xenografts. Two alternatively spliced isoforms of the human proteinhave been described. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family Cellular Component: spindle pole; microtubule organizing center; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; protein kinase binding; ATP binding Biological Process: keratinocyte differentiation; mitosis; regulation of actin filament polymerization; hormone-mediated signaling; cell division; cytoplasmic sequestering of protein; sister chromatid segregation; negative regulation of cyclin-dependent protein kinase activity; regulation of protein complex assembly; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation Reference #:  O95835 (UniProtKB) Alt. Names/Synonyms: h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts Gene Symbols: LATS1 Molecular weight: 126,870 Da Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states CST Pathways:  Hippo Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LATS1

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	Sites Implicated In
enzymatic activity, induced: S909‑p, T1079‑p protein degradation: S464‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		T17-p	YRQMRPKtFPASNyT
0	1		Y23-p	KtFPASNyTVssRQM
0	2		S26-p	PASNyTVssRQMLQE
0	1		S27-p	ASNyTVssRQMLQEI
0	1		N93	LPFANETNSSRSTSE
0	1		Y143-p	EFISKMSyQDPRREQ
0	1		S171-p	KPGNVQQsVNRKQsW
0	4		S177-p	QsVNRKQsWKGsKES
0	4		S181-p	RKQsWKGsKESLVPQ
0	1		S204	SVAYHSESPNSQTDV
0	1		S207	YHSESPNSQTDVGRP
0	1		S216	TDVGRPLSGSGISAF
0	1		S244-p	PPPPQVRsVtPPPPP
0	16		T246-p	PPQVRsVtPPPPPRG
0	6		T255-p	PPPPRGQtPPPRGTT
0	2		Y277-p	PNSQTKRysGNMEyV
0	15		S278-p	NSQTKRysGNMEyVI
0	39		Y283-p	RysGNMEyVISRISP
0	2		S336-p	PIIMQSSsKFNFPSG
1	25		S464-p	NIPVRSNsFNNPLGN
1	0		T490-p	ATTVTAItPAPIQQP
0	1		T612-p	KEKKQITtsPITVRK
1	9		S613-p	EKKQITtsPITVRKN
0	1		S633-p	RRESRIQsYSPQAFK
1	1		S674-p	EMMRVGLsQDAQDQM
0	2		K683	DAQDQMRKMLCQKES
0	1		S792-p	IPGGDMMsLLIRMGI
0	1		S864-p	HDSKYYQsGDHPRQD
1	2		S872-p	GDHPRQDsMDFSNEW
3	4		S909-p	HQRCLAHsLVGTPNY
1	0		T967-p	MKVINWQtSLHIPPQ
1	0		T1012-p	KAHPFFKtIDFSSDL
1	0		S1049-p	VDPDKLWsDDNEEEN
1	4		T1060-p	EEENVNDtLNGWYKN
0	6		Y1076-p	KHPEHAFyEFtFRRF
2	0		T1079-p	EHAFyEFtFRRFFDD
0	2		S1111-p	SQGSEQQsDEDDQNT

	mouse
T17	YRQMRPKTFPASNYP
Y23	KTFPASNYPGSSRQM
S26	PASNYPGSSRQMLQE
S27	ASNYPGSSRQMLQEI
S93-p	LPFANETsSSRSPSE
Y143	EFISKMSYQDPRREQ
S171	KPGNVQHSINRKQsW
S177-p	HSINRKQsWKGsKES
S181-p	RKQsWKGsKESLVPQ
S204-p	NVVYRSEsPNsQADV
S207-p	YRSEsPNsQADVGRP
S216-p	ADVGRPLsGSGIAAF
S244	PPPPQVRSVtPPPPP
T246-p	PPQVRSVtPPPPPRG
T255-p	PPPPRGQtPPPRGTT
Y277-p	PSSQTKRysGNMEYV
S278-p	SSQTKRysGNMEYVI
Y283	RysGNMEYVISRISP
S336	PIIMQSTSKFNFTPG
S463-p	NIPVRSNsFNNPLGS
T489	ATTVTAITPAPIQQP
T611	KEKKQITTsPITVRK
S612-p	EKKQITTsPITVRKN
S632	RRESRIQSYSPQAFK
S673	EMMRVGLSQDAQDQM
K682-a	DAQDQMRkMLCQKES
S791	IPGGDMMSLLIRMGI
S863	HDSKYYQSGDHPRQD
S871	GDHPRQDSMDFSNEW
S908-p	HQRCLAHsLVGTPNY
T966	MKVINWQTSLHIPPQ
T1011	KAHPFFKTIDFSSDL
S1048	VDPDKLWSDGSEEEN
T1059	EEENISDTLNGWYKN
Y1075	KHPEHAFYEFTFRRF
T1078	EHAFYEFTFRRFFDD
S1110	SQGSEQQSDEDDQHT

	rat
T17	YRQMRPKTFPASNYS
Y23	KTFPASNYSGSSRQM
S26	PASNYSGSSRQMLQE
S27	ASNYSGSSRQMLQEI
S93	LPFANETSSSRIPSE
Y143	EFISKMSYQDPRREQ
S171	KPGNVQHSISRKQSW
S177	HSISRKQSWKGSKES
S181	RKQSWKGSKESLVPQ
S204	NVVYRSESPNSQADV
S207	YRSESPNSQADVGRP
S216	ADVGRPLSGSGITAF
S244	PPPPQVRSVTPPPPP
T246	PPQVRSVTPPPPPRG
T255	PPPPRGQTPPPRGTT
Y277	PNSQTKRYSGNMEYV
S278	NSQTKRYSGNMEYVI
Y283	RYSGNMEYVISRISP
S336	PIIMQSTSKFNFTPG
S464	NIPVRSNSFNNPLGS
T490	ATTVTAITPAPIQQP
T612	KEKKQITTSPITVRK
S613	EKKQITTSPITVRKN
S633	RRESRIQSYSPQAFK
S674	EMMRVGLSQDAQDQM
K683	DAQDQMRKMLCQKES
S792	IPGGDMMSLLIRMGI
S864	HDSKYYQSGDHPRQD
S872	GDHPRQDSMDFSSEW
S909	HQRCLAHSLVGTPNY
T967	MKVINWQTSLHIPPQ
T1012	KAHPFFKTIDFSSDL
S1049	VDPDKLWSDGNEEEN
T1060	EEENINDTLNGWYKN
Y1076	KHPEHAFYEFTFRRF
T1079	EHAFYEFTFRRFFDD
S1111	SQGSEQQSDEDDQHT

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