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Protein Page:
LATS1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LATS1 an AGC kinase of the NDR family of kinases. Localized to the mitotic apparatus and specifically phosphorylated during mitosis. A likely tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity, causing G2 arrest. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. Complexes with CDC2 in early mitosis. LATS1-associated CDC2 has no mitotic cyclin partner and no apparent kinase activity. Binds phosphorylated zyxin, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. Knockout mice are susceptible to soft-tissue sarcomas and sensitive to chemical carcinogenesis. Human soft tissue sarcomas have downregulated, mutated, and/or hypermethylated LATS1. Transgenic expression blocks anchorage independent growth in culture and tumor growth in xenografts. Two alternatively spliced isoforms of the human proteinhave been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; NDR family
Cellular Component: spindle pole; microtubule organizing center; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; protein kinase binding; ATP binding
Biological Process: keratinocyte differentiation; mitosis; regulation of actin filament polymerization; hormone-mediated signaling; sister chromatid segregation; cytoplasmic sequestering of protein; negative regulation of cyclin-dependent protein kinase activity; regulation of protein complex assembly; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation
Reference #:  O95835 (UniProtKB)
Alt. Names/Synonyms: h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols: LATS1
Molecular weight: 126,870 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LATS1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S909‑p, T1079‑p
protein degradation: S464‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 T17-p YRQMRPKtFPASNYT
0 2 S26-p PASNYTVsSRQMLQE
0 1 N93 LPFANETNSSRSTSE
0 4 S177-p QSVNRKQsWKGsKES
0 4 S181-p RKQsWKGsKESLVPQ
0 1 S204 SVAYHSESPNSQTDV
0 1 S207 YHSESPNSQTDVGRP
0 1 S216 TDVGRPLSGSGISAF
0 1 S244-p PPPPQVRsVtPPPPP
0 18 T246-p PPQVRsVtPPPPPRG
0 6 T255-p PPPPRGQtPPPRGTT
0 2 Y277-p PNSQTKRysGNMEyV
0 15 S278-p NSQTKRysGNMEyVI
0 39 Y283-p RysGNMEyVISRISP
0 2 S336-p PIIMQSSsKFNFPSG
1 27 S464-p NIPVRSNsFNNPLGN
1 0 T490-p ATTVTAItPAPIQQP
0 1 T612-p KEKKQITtsPITVRK
1 10 S613-p EKKQITtsPITVRKN
0 1 S633-p RRESRIQsYSPQAFK
1 1 S674-p EMMRVGLsQDAQDQM
0 2 K683 DAQDQMRKMLCQKES
1 2 S872-p GDHPRQDsMDFSNEW
6 4 S909-p HQRCLAHsLVGTPNY
1 0 T967-p MKVINWQtSLHIPPQ
1 0 T1012-p KAHPFFKtIDFSSDL
1 0 S1049-p VDPDKLWsDDNEEEN
1 4 T1060-p EEENVNDtLNGWYKN
0 6 Y1076-p KHPEHAFyEFtFRRF
4 0 T1079-p EHAFyEFtFRRFFDD
0 2 S1111-p SQGSEQQsDEDDQNT
9157 : Phospho-LATS1 (Ser909) Antibody
9159 : Phospho-LATS1 (Thr1079) Antibody
  mouse

 
T17 YRQMRPKTFPASNYP
S26 PASNYPGSSRQMLQE
S93-p LPFANETsSSRSPSE
S177-p HSINRKQsWKGsKES
S181-p RKQsWKGsKESLVPQ
S204-p NVVYRSEsPNsQADV
S207-p YRSEsPNsQADVGRP
S216-p ADVGRPLsGSGIAAF
S244 PPPPQVRSVtPPPPP
T246-p PPQVRSVtPPPPPRG
T255-p PPPPRGQtPPPRGTT
Y277-p PSSQTKRysGNMEYV
S278-p SSQTKRysGNMEYVI
Y283 RysGNMEYVISRISP
S336 PIIMQSTSKFNFTPG
S463-p NIPVRSNsFNNPLGS
T489 ATTVTAITPAPIQQP
T611-p KEKKQITtsPITVRK
S612-p EKKQITtsPITVRKN
S632 RRESRIQSYSPQAFK
S673 EMMRVGLSQDAQDQM
K682-a DAQDQMRkMLCQKES
S871 GDHPRQDSMDFSNEW
S908-p HQRCLAHsLVGTPNY
T966 MKVINWQTSLHIPPQ
T1011 KAHPFFKTIDFSSDL
S1048 VDPDKLWSDGSEEEN
T1059 EEENISDTLNGWYKN
Y1075 KHPEHAFYEFtFRRF
T1078-p EHAFYEFtFRRFFDD
S1110 SQGSEQQSDEDDQHT
9157 : Phospho-LATS1 (Ser909) Antibody
9159 : Phospho-LATS1 (Thr1079) Antibody
  rat

 
T17 YRQMRPKTFPASNYS
S26 PASNYSGSSRQMLQE
S93 LPFANETSSSRIPSE
S177 HSISRKQSWKGSKES
S181 RKQSWKGSKESLVPQ
S204 NVVYRSESPNSQADV
S207 YRSESPNSQADVGRP
S216 ADVGRPLSGSGITAF
S244 PPPPQVRSVTPPPPP
T246 PPQVRSVTPPPPPRG
T255 PPPPRGQTPPPRGTT
Y277 PNSQTKRYSGNMEYV
S278 NSQTKRYSGNMEYVI
Y283 RYSGNMEYVISRISP
S336 PIIMQSTSKFNFTPG
S464 NIPVRSNSFNNPLGS
T490 ATTVTAITPAPIQQP
T612 KEKKQITTSPITVRK
S613 EKKQITTSPITVRKN
S633 RRESRIQSYSPQAFK
S674 EMMRVGLSQDAQDQM
K683 DAQDQMRKMLCQKES
S872 GDHPRQDSMDFSSEW
S909 HQRCLAHSLVGTPNY
T967 MKVINWQTSLHIPPQ
T1012 KAHPFFKTIDFSSDL
S1049 VDPDKLWSDGNEEEN
T1060 EEENINDTLNGWYKN
Y1076 KHPEHAFYEFTFRRF
T1079 EHAFYEFTFRRFFDD
S1111 SQGSEQQSDEDDQHT
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