Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IKKG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKKG a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2). Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; intracellular; IkappaB kinase complex; nucleus; cytosol
Molecular Function: protein domain specific binding; protein binding; signal transducer activity; protein homodimerization activity; protein heterodimerization activity; metal ion binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to DNA damage stimulus
Reference #:  Q9Y6K9 (UniProtKB)
Alt. Names/Synonyms: AMCBX1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator
Gene Symbols: IKBKG
Molecular weight: 48,198 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKG

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, altered: S85‑p
activity, induced: K285‑ub
intracellular localization: S85‑p
molecular association, regulation: S68‑p, S85‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S31-p QDVLGEEsPLGKPAM
2 0 S43-p PAMLHLPsEQGAPET
1 0 S68-p LRDAIRQsNQILRER
4 0 S85-p ELLHFQAsQREEKEF
0 1 K143-ub AEDKASVkAQVTSLL
0 1 S178-p EGRARAAsEQARQLE
0 1 S221 RMERQAASEEKRKLA
0 1 K255-ac SVVGSERkRGMQLED
1 1 K277-ub AEEALVAkQEVIDkL
4 0 K277-sm AEEALVAkQEVIDkL
0 1 K283-ub AkQEVIDkLkEEAEQ
5 14 K285-ub QEVIDkLkEEAEQHk
0 1 K292-ub kEEAEQHkIVMEtVP
0 1 T297-p QHkIVMEtVPVLKAQ
0 1 Y308-p LKAQADIykADFQAE
3 2 K309-ub KAQADIykADFQAER
3 0 K309-sm KAQADIykADFQAER
1 0 K321-ub AERQAREkLAEkkEL
1 1 K325-ub AREkLAEkkELLQEQ
1 0 K326-ub REkLAEkkELLQEQL
0 15 K344-ub QREYSKLkASCQESA
0 1 S350 LkASCQESARIEDMR
1 11 Y374-p PLPPAPAyLssPLAL
3 7 S376-p PPAPAyLssPLALPs
1 55 S377-p PAPAyLssPLALPsQ
1 0 P382 LssPLALPsQRRsPP
0 5 S383-p ssPLALPsQRRsPPE
1 14 S387-p ALPsQRRsPPEEPPD
3 0 K399-ub PPDFCCPkCQYQAPD
2689 : Phospho-IKKgamma (Ser376) Antibody
  mouse

 
S31 QDMLGEESSLGKPAM
S43 PAMLHLPSEQGTPET
S68 LRDAIRQSNQMLRER
S85-p ELLHFQVsQREEKEF
K143 AEDKASVKAQVTSLL
S178 EGRIRAVSEQVRQLE
S221-p RMERQAAsEEKRKLA
- gap
K270-ub AEEALVAkQELIDKL
K270-sm AEEALVAkQELIDKL
K276 AkQELIDKLKEEAEQ
K278 QELIDKLKEEAEQHK
K285 KEEAEQHKIVMETVP
T290 QHKIVMETVPVLKAQ
Y301 LKAQADIYkADFQAE
K302-ub KAQADIYkADFQAER
K302 KAQADIYKADFQAER
K314 AERHAREKLVEKKEY
K318 AREKLVEKKEYLQEQ
K319 REKLVEKKEYLQEQL
K337-ub QREFNKLkVGCHEsA
S343-p LkVGCHEsARIEDMR
H367 PLLPAPAHHsFHLAL
S369-p LPAPAHHsFHLALsN
F370 PAPAHHsFHLALsNQ
S375-p HsFHLALsNQRRsPP
N376 sFHLALsNQRRsPPE
S380-p ALsNQRRsPPEEPPD
K392 PPDFCCPKCQYQAPD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.