Home

IKK-gamma (human)

Overview IKK-gamma a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2). Note: This description may include information from UniProtKB. Protein type: Protein kinase, regulatory subunit; Adaptor/scaffold Cellular Component: cytoplasm; cytoplasmic part; intracellular; IkappaB kinase complex; nucleus; cytosol Molecular Function: protein domain specific binding; protein binding; signal transducer activity; metal ion binding Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; virus-host interaction; induction of apoptosis; toll-like receptor signaling pathway; innate immune response; immune response; response to DNA damage stimulus Reference #:  Q9Y6K9 (UniProtKB) Alt. Names/Synonyms: AMCBX1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator Gene Symbols: IKBKG Molecular weight: 48,198 Da Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IKK-gamma 2JVX - A=394-419 (human) 2JVY - A=394-419 (human) 3BRT - D/B=44-111 (human) 3BRV - D/B=44-111 (human) 3CL3 - D=150-272 (human) 3FX0 - A/B=246-337 (human) 2V4H - A/B=251-337 (mouse) 3F89 - A/B=250-339 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2JVX 2JVY 3BRT 3BRV 3CL3 3FX0  |  Phospho3D  |  DISEASE 300248 300291 300301 300584 300636 300640 308300  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S85‑p activation: K285‑u intracellular localization: S85‑p molecular association, regulation: S68‑p, S85‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S31-p	QDVLGEEsPLGKPAM
2	0		S43-p	PAMLHLPsEQGAPET
1	0		S68-p	LRDAIRQsNQILRER
4	0		S85-p	ELLHFQAsQREEKEF
0	1		K143-u	AEDKASVkAQVTSLL
0	1		S178-p	EGRARAAsEQARQLE
0	1		S221	RMERQAASEEKRKLA
0	1		K255-a	SVVGSERkRGMQLED
1	1		K277-u	AEEALVAkQEVIDkL
3	0		K277-s	AEEALVAkQEVIDkL
0	1		K283-u	AkQEVIDkLkEEAEQ
5	14		K285-u	QEVIDkLkEEAEQHk
0	1		K292-u	kEEAEQHkIVMEtVP
0	1		T297-p	QHkIVMEtVPVLKAQ
0	1		Y308-p	LKAQADIykADFQAE
3	2		K309-u	KAQADIykADFQAER
3	0		K309-s	KAQADIykADFQAER
1	0		K321-u	AERQAREkLAEkkEL
1	1		K325-u	AREkLAEkkELLQEQ
1	0		K326-u	REkLAEkkELLQEQL
0	15		K344-u	QREYSKLkASCQESA
0	1		S350	LkASCQESARIEDMR
1	11		Y374-p	PLPPAPAyLssPLAL
3	6		S376-p	PPAPAyLssPLALPs
1	54		S377-p	PAPAyLssPLALPsQ
1	0		P382	LssPLALPsQRRsPP
0	5		S383-p	ssPLALPsQRRsPPE
0	8		S387-p	ALPsQRRsPPEEPPD
3	0		K399-u	PPDFCCPkCQYQAPD

	mouse
S31	QDMLGEESSLGKPAM
S43	PAMLHLPSEQGTPET
S68	LRDAIRQSNQMLRER
S85-p	ELLHFQVsQREEKEF
K143	AEDKASVKAQVTSLL
S178	EGRIRAVSEQVRQLE
S221-p	RMERQAAsEEKRKLA
-	gap
K270-u	AEEALVAkQELIDKL
K270	AEEALVAKQELIDKL
K276	AkQELIDKLKEEAEQ
K278	QELIDKLKEEAEQHK
K285	KEEAEQHKIVMETVP
T290	QHKIVMETVPVLKAQ
Y301	LKAQADIYkADFQAE
K302-u	KAQADIYkADFQAER
K302	KAQADIYKADFQAER
K314	AERHAREKLVEKKEY
K318	AREKLVEKKEYLQEQ
K319	REKLVEKKEYLQEQL
K337-u	QREFNKLkVGCHEsA
S343-p	LkVGCHEsARIEDMR
H367	PLLPAPAHHsFHLAL
S369-p	LPAPAHHsFHLALsN
F370	PAPAHHsFHLALsNQ
S375-p	HsFHLALsNQRRsPP
N376	sFHLALsNQRRsPPE
S380-p	ALsNQRRsPPEEPPD
K392	PPDFCCPKCQYQAPD

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.