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Protein Page:
IKKG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IKKG a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2). Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Adaptor/scaffold
Cellular Component: cytoplasm; IkappaB kinase complex; intracellular; cytosol; nucleus
Molecular Function: protein domain specific binding; protein binding; signal transducer activity; protein homodimerization activity; protein heterodimerization activity; metal ion binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immune response; toll-like receptor 9 signaling pathway; response to DNA damage stimulus
Reference #:  Q9Y6K9 (UniProtKB)
Alt. Names/Synonyms: AMCBX1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator
Gene Symbols: IKBKG
Molecular weight: 48,198 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKG

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, altered: S85‑p
activity, induced: K285‑u
intracellular localization: S85‑p
molecular association, regulation: S68‑p, S85‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S31-p QDVLGEEsPLGKPAM
2 0 S43-p PAMLHLPsEQGAPET
1 0 S68-p LRDAIRQsNQILRER
4 0 S85-p ELLHFQAsQREEKEF
0 1 S221 RMERQAASEEKRKLA
1 1 K277-u AEEALVAkQEVIDKL
4 0 K277-s AEEALVAkQEVIDKL
5 14 K285-u QEVIDKLkEEAEQHK
0 1 T297-p QHKIVMEtVPVLKAQ
3 2 K309-u KAQADIYkADFQAER
3 0 K309-s KAQADIYkADFQAER
1 0 K321-u AERQAREkLAEkkEL
1 1 K325-u AREkLAEkkELLQEQ
1 0 K326-u REkLAEkkELLQEQL
0 15 K344-u QREYSKLkASCQESA
1 11 Y374-p PLPPAPAyLssPLAL
3 7 S376-p PPAPAyLssPLALPs
1 54 S377-p PAPAyLssPLALPsQ
1 0 P382 LssPLALPsQRRsPP
0 5 S383-p ssPLALPsQRRsPPE
1 10 S387-p ALPsQRRsPPEEPPD
3 0 K399-u PPDFCCPkCQYQAPD
2689 : Phospho-IKKgamma (Ser376) Antibody
  mouse

 
S31 QDMLGEESSLGKPAM
S43 PAMLHLPSEQGTPET
S68 LRDAIRQSNQMLRER
S85-p ELLHFQVsQREEKEF
S221-p RMERQAAsEEKRKLA
K270-u AEEALVAkQELIDKL
K270-s AEEALVAkQELIDKL
K278 QELIDKLKEEAEQHK
T290 QHKIVMETVPVLKAQ
K302-u KAQADIYkADFQAER
K302 KAQADIYKADFQAER
K314 AERHAREKLVEKKEY
K318 AREKLVEKKEYLQEQ
K319 REKLVEKKEYLQEQL
K337-u QREFNKLkVGCHESA
H367 PLLPAPAHHsFHLAL
S369-p LPAPAHHsFHLALsN
F370 PAPAHHsFHLALsNQ
S375-p HsFHLALsNQRRsPP
N376 sFHLALsNQRRsPPE
S380-p ALsNQRRsPPEEPPD
K392 PPDFCCPKCQYQAPD
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