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Protein Page:
MAST2 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAST2 Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; MAST family
Cellular Component: microtubule cytoskeleton; cytoskeleton; membrane; cytoplasm; cell junction
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; microtubule binding; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; magnesium ion binding; kinase activity; ATP binding; protein kinase activity; phosphatase binding
Biological Process: spermatid differentiation; regulation of interleukin-12 biosynthetic process; protein amino acid phosphorylation; phosphorylation
Reference #:  Q60592 (UniProtKB)
Alt. Names/Synonyms: Mast2; Mast205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2; mKIAA0807; Mtssk
Gene Symbols: Mast2
Molecular weight: 190,534 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Select Structure to View Below

MAST2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 9 S6 __MVTGLSPLLFRKL
0 69 S14-p PLLFRKLsNPDIFAP
0 1 P21 sNPDIFAPTGKVKLQ
0 24 S32-p VKLQRQLsQDDCKLR
0 3 S42-p DCKLRRGsLASSLSG
0 2 S84 LVRMRNQSLGQsAPs
0 18 S88-p RNQSLGQsAPsLTAG
0 2 S91-p SLGQsAPsLTAGLKE
0 3 S106-p LSLPRRGsFCRTSNR
0 1 S121-p KSLIVTSsTsPTLPR
0 2 S123-p LIVTSsTsPTLPRPH
0 2 S131-p PTLPRPHsPLHGHTG
0 2 S144-p TGNSPLDsPRNFsPN
0 8 S149-p LDsPRNFsPNAPAHF
0 4 S170-p RTDGRRWsLASLPSS
0 6 S218-p HFLTKHFsTENVPDE
0 2 T219 FLTKHFsTENVPDEE
0 1 N221 TKHFsTENVPDEEGR
0 9 S230-p PDEEGRRsPRMRPRs
0 7 S237-p sPRMRPRsRsLsPGR
0 30 S239-p RMRPRsRsLsPGRsP
0 28 S241-p RPRsRsLsPGRsPVS
0 1 S245-p RsLsPGRsPVSFDSE
0 1 Y402 IKCDIPRYIVSQLGL
0 1 S766 ERYHHVDSEDEEEVS
0 7 S796-p RFSKVYSsMERLSLL
0 2 T808 SLLEERRTPPPTKRS
0 1 S815 TPPPTKRSLsEEKED
0 4 S817-p PPTKRSLsEEKEDHS
0 5 S836-p GLKGRDRsWVIGsPE
0 15 S841-p DRsWVIGsPEILRKR
0 1 S855-p RLSVSESsHTEsDSS
0 1 S859-p SESsHTEsDSSPPMT
0 2 S872 MTVRHRCSGLPDGPH
0 1 S931 EEPPGQSSRCCPALE
0 1 C933 PPGQSSRCCPALETR
0 1 C934 PGQSSRCCPALETRG
0 6 R942-m1 PALETRGrGTPQLAE
0 54 S970-p RARHRLLsGDsIEKR
0 9 S973-p HRLLsGDsIEKRTTR
0 1 S988-p PVNKVIKsASATALS
0 1 S1023-p SQSSNPSsRDSSPSR
0 12 K1141 IKVGPARKGSYKAKM
0 2 K1145 PARKGSYKAKMARRS
0 11 K1147 RKGSYKAKMARRSKR
0 2 S1178-p RKITKQAsLLHTSRs
0 1 S1185-p sLLHTSRsLSSLNRS
0 2 S1194-p SSLNRSLssGESGPG
0 1 S1195-p SLNRSLssGESGPGs
0 1 S1202-p sGESGPGsPTHSHSL
0 3 S1275-p YRSPRRKsAGSIPLS
0 1 S1300-p TAASPQRsPsPLSGH
0 2 S1302-p ASPQRsPsPLSGHGS
0 4 S1319-p FPTKLHLsPPLGRQL
0 3 S1331 RQLSRPKSAEPPRsP
1 4 S1337-p KSAEPPRsPLLKRVQ
0 2 S1345-p PLLKRVQsAEKLAAA
0 7 S1367-p LAPSRKHsLDLPHGE
0 1 S1385 ELTPREASPLEVVGT
0 2 S1441-p EAIREVDssEDDtDE
0 2 S1442-p AIREVDssEDDtDEE
0 2 T1446-p VDssEDDtDEEPENS
0 2 S1462-p ATQEPRLsPHPEASH
0 2 S1522-p GLSPRKVsRPQAFEE
0 1 F1596 PGTWSWKFLIEGPDR
0 2 S1605-p IEGPDRAsTNKTITR
0 1 S1700-p PCRAHPLsPETRPSL
0 1 T1703 AHPLsPETRPSLLWK
0 1 S1706 LsPETRPSLLWKsQE
0 1 S1711-p RPSLLWKsQELGGQQ
  MAST2 iso3  
S67-p QDMVTGLsPLLFRKL
S75 PLLFRKLSNPDIFAP
P82 SNPDIFAPTGKVKLQ
S93 VKLQRQLSQDDCKLR
S103 DCKLRRGSLASSLSG
S145 LVRMRNQSLGQSAPS
S149 RNQSLGQSAPSLTAG
S152 SLGQSAPSLTAGLKE
S167 LSLPRRGSFCRTSNR
S182 KSLIVTSSTSPTLPR
S184 LIVTSSTSPTLPRPH
S192 PTLPRPHSPLHGHTG
S205 TGNSPLDSPRNFSPN
S210 LDSPRNFSPNAPAHF
S238 RTDGRRWSLASLPSS
S286 HFLTKHFSTENVPDE
T287 FLTKHFSTENVPDEE
N289 TKHFSTENVPDEEGR
S298 PDEEGRRSPAMRPRS
S305 SPAMRPRSRSLSPGR
S307 AMRPRSRSLSPGRSP
S309 RPRSRSLSPGRSPVS
S313 RSLSPGRSPVSFDSE
Y469 IKCDIPRYIVSQLGL
S833 ERYHHVDSEDEEEVS
S863 RFSKVYSSMERLSLL
T875 SLLEERRTPPPTKRS
S882 TPPPTKRSLSEEKED
S884 PPTKRSLSEEKEDHS
S903 GLKGRDRSWVIGSPE
S908 DRSWVIGSPEILRKR
S922 RLSVSESSHTESDSS
S926 SESSHTESDSSPPMT
S939 MTVRHRCSGLPDGPH
S998 EEPPGQSSRCCPALE
C1000 PPGQSSRCCPALETR
C1001 PGQSSRCCPALETRG
R1009 PALETRGRGTPQLAE
S1037 RARHRLLSGDSIEKR
S1040 HRLLSGDSIEKRTTR
S1055 PVNKVIKSASATALS
S1090 SQSSNPSSRDSSPSR
K1208 IKVGPARKGSYKAKM
K1212 PARKGSYKAKMARRS
K1214 RKGSYKAKMARRSKR
S1245 RKITKQASLLHTSRS
S1252 SLLHTSRSLSSLNRS
S1261 SSLNRSLSSGESGPG
S1262 SLNRSLSSGESGPGS
S1269 SGESGPGSPTHSHSL
S1341 YRSPRRKSAGSIPLS
S1366 TAASPQRSPSPLSGH
S1368 ASPQRSPSPLSGHGS
S1385 FPTKLHLSPPLGRQL
S1397 RQLSRPKSAEPPRSP
S1403 KSAEPPRSPLLKRVQ
S1411 PLLKRVQSAEKLAAA
S1433 LAPSRKHSLDLPHGE
S1451 ELTPREASPLEVVGT
S1507 EAIREVDSSEDDTDE
S1508 AIREVDSSEDDTDEE
T1512 VDSSEDDTDEEPENS
S1528 ATQEPRLSPHPEASH
S1588 GLSPRKLSRPQAFEE
F1662 PGTWSWKFLIEGPDR
S1671 IEGPDRASTNKTITR
S1766 PCRAHPLSPETRPSL
T1769 AHPLSPETRPSLLWK
S1772 LSPETRPSLLWKSQE
S1777 RPSLLWKSQELGGQQ
  human

 
S66-p QDVVTGVsPLLFRKL
S74-p PLLFRKLsNPDIFSs
S81-p sNPDIFSsTGKVKLQ
S92-p VKLQRQLsQDDCKLW
N102 DCKLWRGNLASSLSG
S144-p LVRMRNQsLGQsAPs
S148-p RNQsLGQsAPsLTAG
S151-p sLGQsAPsLTAGLKE
S166 LSLPRRGSFCRTSNR
S181 KSLIVTSSTsPTLPR
S183-p LIVTSSTsPTLPRPH
S191-p PTLPRPHsPLHGHTG
S204-p TGNSPLDsPRNFsPN
S209-p LDsPRNFsPNAPAHF
S230-p RTDGRRWsLASLPSS
S278-p HFLTKHFstEsVPDE
T279-p FLTKHFstEsVPDEE
S281-p TKHFstEsVPDEEGR
S290-p PDEEGRQsPAMRPRs
S297-p sPAMRPRsRsLsPGR
S299-p AMRPRsRsLsPGRsP
S301-p RPRsRsLsPGRsPVS
S305-p RsLsPGRsPVSFDSE
Y461-p IKCDIPRyIVSQLGL
S825-p ERYHHMDsEDEEEVS
S855-p RFNKVYSsMERLSLL
T867-p SLLEERRtPPPTKRs
S874-p tPPPTKRsLsEEKED
S876-p PPTKRsLsEEKEDHS
S895-p GLKGRDRsWVIGsPE
S900-p DRsWVIGsPEILRKR
S914 RLSVSESSHTESDSS
S918 SESSHTESDSSPPMT
S931-p MTVRRRCsGLLDAPR
S993-p EEAVGRSsGssPAME
S995-p AVGRSsGssPAMETR
S996-p VGRSsGssPAMETRG
R1004-m1 PAMETRGrGTSQLAE
S1032-p RARHRLLsGDSTEKR
S1035 HRLLsGDSTEKRTAR
S1050 PVNKVIKSASATALS
S1085 SQSSNPSSRDSSPSR
K1203-a IKVGPARkGSYkAkM
K1207-a PARkGSYkAkMARRS
K1209-a RkGSYkAkMARRSKR
S1240-p RKITKQAsLLHTSRS
S1247 sLLHTSRSLSSLNRS
S1256-p SSLNRSLsSGESGPG
S1257 SLNRSLsSGESGPGS
S1264 SGESGPGSPTHSHSL
S1337-p YRSPRRKsAGSIPLS
S1362 PTASPQRSPsPLSGH
S1364-p ASPQRSPsPLSGHVA
S1381-p FPTKLHLsPPLGRQL
S1393-p RQLSRPKsAEPPRsP
S1399-p KsAEPPRsPLLKRVQ
S1407-p PLLKRVQsAEKLAAA
S1429-p LATSRKHsLDLPHSE
S1447-p ELPPREVsPLEVVGA
S1503-p EAIREVDssEDDTEE
S1504-p AIREVDssEDDTEEG
T1508 VDssEDDTEEGPENS
A1524 GAQELSLAPHPEVSQ
G1584 SGPHRRLGSPQAIEE
S1660-p LSMWSWKsLIEGPDR
S1669-p IEGPDRAsPSRKATM
T1765 PCRGCPLTQKsEPsL
S1768-p GCPLTQKsEPsLRRG
S1771-p LTQKsEPsLRRGQEP
G1775 sEPsLRRGQEPGGHQ
  rat

 
S67 QDMVSGLSPLLFRKL
S75 PLLFRKLSNPDIFSP
P82 SNPDIFSPTGKAKLQ
S93 AKLQRQLSQDDCKLR
S103 DCKLRRGSLASSLSG
S145 LVRMRNQSLGQSAPS
S149 RNQSLGQSAPSLTAG
S152 SLGQSAPSLTAGLKE
S167 LSLPRRGSFCRTSNR
S182 KSLIVTSSTSPTLPR
S184 LIVTSSTSPTLPRPH
S192 PTLPRPHSPLHGHTG
S205 TGNSPLDSPRNFSPN
S210 LDSPRNFSPNAPAHF
S238 RTDGRRWSLASLPSS
S286 HFLTKHFSTENVPDE
T287 FLTKHFSTENVPDEE
N289 TKHFSTENVPDEEGR
S298 PDEEGRQSPAMRPRS
S305 SPAMRPRSRSLSPGR
S307 AMRPRSRSLSPGRSP
S309 RPRSRSLSPGRSPVS
S313 RSLSPGRSPVSFDSE
Y469 IKCDIPRYIVSQLGL
S833 ERYHHVDSEDEEEVS
S863 RFSKVYSSMERLSLL
T875 SLLEGHRTPPPTKRS
S882 TPPPTKRSLSEEKED
S884 PPTKRSLSEEKEDHS
S903 GLKGRDRSWVIGSPE
S908 DRSWVIGSPEILRKR
S922 RLSVSESSHTESDSS
S926 SESSHTESDSSPPMT
S938 PMTVRHRSGLPDVPR
S997 EEPPGQSSRSCPAME
S999 PPGQSSRSCPAMETR
C1000 PGQSSRSCPAMETRG
R1008 PAMETRGRGTPQLAE
S1036 RARHRLLSGDSIEKR
S1039 HRLLSGDSIEKRTTR
S1054 PVNKVIKSASATALS
S1089 SQSSNPSSRDSSPSR
K1207 IKVGPARKGSSKAKM
K1211 PARKGSSKAKMARRS
K1213 RKGSSKAKMARRSKR
S1244 RKITKQASLLHTSRS
S1251 SLLHTSRSLSSLNRS
S1260 SSLNRSLSSGESGPC
S1261 SLNRSLSSGESGPCS
S1268 SGESGPCSPTHSHSL
S1340 YRSPRRKSAGSIPLS
S1365 AAASPQRSPSPLSGH
S1367 ASPQRSPSPLSGHGS
S1384 FPTKLHLSPPLGRQL
S1396 RQLSRPKSAEPPRSP
S1402 KSAEPPRSPLLKRVQ
S1410 PLLKRVQSAEKLAAA
S1432 LAPSRKHSLDLPHGE
N1450 ELTPREANPLEVVGT
S1506 EAIREVDSSEDDTDE
S1507 AIREVDSSEDDTDEE
T1511 VDSSEDDTDEEPENS
S1527 ATQEPRLSPHPEASQ
W1582 GLSQRKLWRPQAFEE
F1656 PGTWSWKFLIEGPDR
S1665 IEGPDRASTNKKITR
S1761 PCRAHHLSPETRPSL
T1764 AHHLSPETRPSLLWR
S1767 LSPETRPSLLWRSQE
S1772 RPSLLWRSQELGGQQ
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