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Protein Page:
MAST2 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAST2 Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; AGC group; MAST family
Cellular Component: microtubule cytoskeleton; cytoskeleton; membrane; cytoplasm; cell junction
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; metal ion binding; microtubule binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; magnesium ion binding; kinase activity; ATP binding; phosphatase binding; protein kinase activity
Biological Process: spermatid differentiation; regulation of interleukin-12 biosynthetic process; phosphorylation; protein amino acid phosphorylation
Reference #:  NP_001036208 (RefSeq)
Alt. Names/Synonyms: Mast2; Mast205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2; mKIAA0807; Mtssk
Gene Symbols: Mast2
Molecular weight: 198,054 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Select Structure to View Below

MAST2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        mouse

 
0 1 R49 GRQLLEERSGPLGHD
0 1 R58 GPLGHDSREQDMVTG
0 7 S67-p QDMVTGLsPLLFRKL
0 1 R72 GLsPLLFRKLsNPDI
0 64 S75-p PLLFRKLsNPDIFAP
0 1 P82 sNPDIFAPTGKVKLQ
0 1 T83 NPDIFAPTGKVKLQR
0 23 S93-p VKLQRQLsQDDCKLR
0 3 S103-p DCKLRRGsLASSLSG
0 2 S145 LVRMRNQSLGQsAPs
0 15 S149-p RNQSLGQsAPsLTAG
0 2 S152-p SLGQsAPsLTAGLKE
0 3 S167-p LSLPRRGsFCRTSNR
0 1 S182-p KSLIVTSsTsPTLPR
0 2 S184-p LIVTSsTsPTLPRPH
0 1 T186 VTSsTsPTLPRPHsP
0 2 S192-p PTLPRPHsPLHGHTG
0 2 S205-p TGNSPLDsPRNFsPN
0 7 S210-p LDsPRNFsPNAPAHF
0 3 S238-p RTDGRRWsLASLPSS
0 1 T282 ADELHFLTKHFsTEN
0 5 S286-p HFLTKHFsTENVPDE
0 2 T287 FLTKHFsTENVPDEE
0 1 N289 TKHFsTENVPDEEGR
0 8 S298-p PDEEGRRsPAMRPRs
0 6 S305-p sPAMRPRsRsLsPGR
0 28 S307-p AMRPRsRsLsPGRsP
0 26 S309-p RPRsRsLsPGRsPVS
0 1 S313-p RsLsPGRsPVSFDSE
0 1 Y469 IKCDIPRYIVSQLGL
0 1 Y820 ESEDDTSYFDTRSER
0 1 Y861 SPRFSKVYSsMERLS
0 1 S862 PRFSKVYSsMERLSL
0 7 S863-p RFSKVYSsMERLSLL
0 1 S868 YSsMERLSLLEERRT
0 1 T875 SLLEERRTPPPTKRS
0 1 T879 ERRTPPPTKRSLsEE
0 3 S884-p PPTKRSLsEEKEDHS
0 5 S903-p GLKGRDRsWVIGsPE
0 11 S908-p DRsWVIGsPEILRKR
0 1 S922-p RLSVSESsHTEsDSS
0 1 S926-p SESsHTEsDSSPPMT
0 1 S928 SsHTEsDSSPPMTVR
0 1 S998 EEPPGQSSRCCPALE
0 1 C1000 PPGQSSRCCPALETR
0 1 C1001 PGQSSRCCPALETRG
0 5 R1009-m1 PALETRGrGTPQLAE
0 53 S1037-p RARHRLLsGDsIEKR
0 9 S1040-p HRLLsGDsIEKRTTR
0 1 S1055-p PVNKVIKsASATALS
0 1 S1090-p SQSSNPSsRDSSPSR
0 1 K1188 LVLKSGNKVSISTTP
0 1 K1202 PLENTSIKVGPARKG
0 12 K1208 IKVGPARKGSYKAKM
0 2 K1212 PARKGSYKAKMARRS
0 11 K1214 RKGSYKAKMARRSKR
0 1 S1245-p RKITKQAsLLHTSRs
0 1 S1252-p sLLHTSRsLSSLNRS
0 1 S1261-p SSLNRSLssGESGPG
0 1 S1262-p SLNRSLssGESGPGs
0 1 S1269-p sGESGPGsPTHSHSL
0 1 S1280 SHSLSPRSPPQGYRV
0 2 S1341-p YRSPRRKsAGSIPLS
0 1 S1344 PRRKsAGSIPLSPLA
0 1 T1353 PLSPLAHTPSPPATA
0 1 S1355 SPLAHTPSPPATAAS
0 1 S1366-p TAASPQRsPsPLSGH
0 1 S1368-p ASPQRsPsPLSGHGS
0 2 S1385-p FPTKLHLsPPLGRQL
0 2 S1397 RQLSRPKSAEPPRsP
1 3 S1403-p KSAEPPRsPLLKRVQ
0 2 S1411-p PLLKRVQsAEKLAAA
0 1 S1429 AEKKLAPSRKHsLDL
0 7 S1433-p LAPSRKHsLDLPHGE
0 1 G1439 HsLDLPHGELKKELT
0 2 S1507-p EAIREVDssEDDtDE
0 2 S1508-p AIREVDssEDDtDEE
0 2 T1512-p VDssEDDtDEEPENS
0 2 S1528-p ATQEPRLsPHPEASH
0 2 S1588-p GLSPRKLsRPQAFEE
0 1 S1652-p CSAATSTsGKPGTWS
0 1 S1671-p IEGPDRAsTNKTITR
0 1 S1766-p PCRAHPLsPETRPSL
0 1 T1769 AHPLsPETRPSLLWK
0 1 S1772 LsPETRPSLLWKsQE
0 1 S1777-p RPSLLWKsQELGGQQ
  human

 
R48 GRQRLEERTGPAGPE
K57 GPAGPEGKEQDVVTG
S66-p QDVVTGVsPLLFRKL
R71 GVsPLLFRKLsNPDI
S74-p PLLFRKLsNPDIFSs
S81-p sNPDIFSstGKVKLQ
T82-p NPDIFSstGKVKLQR
S92-p VKLQRQLsQDDCKLW
N102 DCKLWRGNLASSLSG
S144-p LVRMRNQsLGQsAPs
S148-p RNQsLGQsAPsLTAG
S151-p sLGQsAPsLTAGLKE
S166 LSLPRRGSFCRTSNR
S181 KSLIVTSSTsPtLPR
S183-p LIVTSSTsPtLPRPH
T185-p VTSSTsPtLPRPHsP
S191-p PtLPRPHsPLHGHTG
S204-p TGNSPLDsPRNFsPN
S209-p LDsPRNFsPNAPAHF
S230-p RTDGRRWsLASLPSS
T274-p ADELHFLtKHFstEs
S278-p HFLtKHFstEsVPDE
T279-p FLtKHFstEsVPDEE
S281-p tKHFstEsVPDEEGR
S290-p PDEEGRQsPAMRPRs
S297-p sPAMRPRsRsLsPGR
S299-p AMRPRsRsLsPGRsP
S301-p RPRsRsLsPGRsPVS
S305-p RsLsPGRsPVSFDSE
Y461-p IKCDIPRyIVSQLGL
Y812-p ESEDDTSyFDTRSER
Y853-p SPRFNKVyssMERLs
S854-p PRFNKVyssMERLsL
S855-p RFNKVyssMERLsLL
S860-p yssMERLsLLEERRt
T867-p sLLEERRtPPPtKRS
T871-p ERRtPPPtKRSLsEE
S876-p PPtKRSLsEEKEDHS
S895-p GLKGRDRsWVIGsPE
S900-p DRsWVIGsPEILRKR
S914 RLSVSESSHTESDsS
S918 SESSHTESDsSPPMT
S920-p SSHTESDsSPPMTVR
S993-p EEAVGRSsGssPAME
S995-p AVGRSsGssPAMETR
S996-p VGRSsGssPAMETRG
R1004-m1 PAMETRGrGTSQLAE
S1032-p RARHRLLsGDsTEKR
S1035-p HRLLsGDsTEKRTAR
S1050 PVNKVIKSASATALS
S1085 SQSSNPSSRDSSPSR
K1183-u LILKSGNkVAISTTP
K1197-u PLENTSIkVGPARkG
K1203-a IkVGPARkGSYkAkM
K1207-a PARkGSYkAkMARRS
K1209-a RkGSYkAkMARRSKR
S1240-p RKITKQAsLLHTSRS
S1247 sLLHTSRSLSSLNRS
S1256 SSLNRSLSSGESGPG
S1257 SLNRSLSSGESGPGS
S1264 SGESGPGSPTHSHSL
S1275-p SHSLSPRsPTQGYRV
S1337 YRSPRRKSAGsIPLS
S1340-p PRRKSAGsIPLSPLA
T1349-p PLSPLAHtPsPPPPT
S1351-p SPLAHtPsPPPPTAS
S1362 PTASPQRSPSPLSGH
S1364 ASPQRSPSPLSGHVA
S1381-p FPTKLHLsPPLGRQL
S1393-p RQLSRPKsAEPPRsP
S1399-p KsAEPPRsPLLKRVQ
S1407-p PLLKRVQsAEKLAAA
S1425-p SEKKLATsRKHsLDL
S1429-p LATsRKHsLDLPHsE
S1435-p HsLDLPHsELKKELP
S1503 EAIREVDSSEDDTEE
S1504 AIREVDSSEDDTEEG
T1508 VDSSEDDTEEGPENS
A1524 GAQELSLAPHPEVSQ
G1584 SGPHRRLGSPQAIEE
S1650 CSPPSSTSGKLSMWS
S1669 IEGPDRASPSRKATM
T1765-p PCRGCPLtQKsEPsL
S1768-p GCPLtQKsEPsLRRG
S1771-p LtQKsEPsLRRGQEP
G1775 sEPsLRRGQEPGGHQ
  rat

 
R49-m1 GRQLLEErSGPMGHD
R58-m1 GPMGHDSrEQDMVSG
S67 QDMVSGLSPLLFrKL
R72-m1 GLSPLLFrKLSNPDI
S75 PLLFrKLSNPDIFSP
P82 SNPDIFSPTGKAKLQ
T83 NPDIFSPTGKAKLQR
S93 AKLQRQLSQDDCKLR
S103 DCKLRRGSLASSLSG
S145 LVRMRNQSLGQSAPS
S149 RNQSLGQSAPSLTAG
S152 SLGQSAPSLTAGLKE
S167 LSLPRRGSFCRTSNR
S182 KSLIVTSSTSPTLPR
S184 LIVTSSTSPTLPRPH
T186 VTSSTSPTLPRPHSP
S192 PTLPRPHSPLHGHTG
S205 TGNSPLDSPRNFSPN
S210 LDSPRNFSPNAPAHF
S238 RTDGRRWSLASLPSS
T282 ADELHFLTKHFSTEN
S286 HFLTKHFSTENVPDE
T287 FLTKHFSTENVPDEE
N289 TKHFSTENVPDEEGR
S298 PDEEGRQSPAMRPRS
S305 SPAMRPRSRSLSPGR
S307 AMRPRSRSLSPGRSP
S309 RPRSRSLSPGRSPVS
S313 RSLSPGRSPVSFDSE
Y469 IKCDIPRYIVSQLGL
Y820 ESEDDTSYFDTRSER
Y861 SPRFSKVYSSMERLS
S862 PRFSKVYSSMERLSL
S863 RFSKVYSSMERLSLL
S868 YSSMERLSLLEGHRT
T875 SLLEGHRTPPPTKRS
T879 GHRTPPPTKRSLSEE
S884 PPTKRSLSEEKEDHS
S903 GLKGRDRSWVIGSPE
S908 DRSWVIGSPEILRKR
S922 RLSVSESSHTESDSS
S926 SESSHTESDSSPPMT
S928 SSHTESDSSPPMTVR
S997 EEPPGQSSRSCPAME
S999 PPGQSSRSCPAMETR
C1000 PGQSSRSCPAMETRG
R1008 PAMETRGRGTPQLAE
S1036 RARHRLLSGDSIEKR
S1039 HRLLSGDSIEKRTTR
S1054 PVNKVIKSASATALS
S1089 SQSSNPSSRDSSPSR
K1187 LVLKSGNKVSISTTP
K1201 PLENTSIKVGPARKG
K1207 IKVGPARKGSSKAKM
K1211 PARKGSSKAKMARRS
K1213 RKGSSKAKMARRSKR
S1244 RKITKQASLLHTSRS
S1251 SLLHTSRSLSSLNRS
S1260 SSLNRSLSSGESGPC
S1261 SLNRSLSSGESGPCS
S1268 SGESGPCSPTHSHSL
S1279 SHSLSPRSPPQGYRV
S1340 YRSPRRKSAGSIPLS
S1343 PRRKSAGSIPLSPLA
T1352 PLSPLAHTPSPPAAA
S1354 SPLAHTPSPPAAAAS
S1365 AAASPQRSPSPLSGH
S1367 ASPQRSPSPLSGHGS
S1384 FPTKLHLSPPLGRQL
S1396 RQLSRPKSAEPPRSP
S1402 KSAEPPRSPLLKRVQ
S1410 PLLKRVQSAEKLAAA
S1428 AEKKLAPSRKHSLDL
S1432 LAPSRKHSLDLPHGE
G1438 HSLDLPHGELKKELT
S1506 EAIREVDSSEDDTDE
S1507 AIREVDSSEDDTDEE
T1511 VDSSEDDTDEEPENS
S1527 ATQEPRLSPHPEASQ
W1582 GLSQRKLWRPQAFEE
S1646 CSAATSTSGKPGTWS
S1665 IEGPDRASTNKKITR
S1761 PCRAHHLSPETRPSL
T1764 AHHLSPETRPSLLWR
S1767 LSPETRPSLLWRSQE
S1772 RPSLLWRSQELGGQQ
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