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Protein Page:
MAST2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAST2 Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; MAST family
Cellular Component: microtubule cytoskeleton; cytoskeleton; membrane; cytoplasm; cell junction
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; metal ion binding; microtubule binding; transferase activity, transferring phosphorus-containing groups; magnesium ion binding; nucleotide binding; kinase activity; ATP binding; protein kinase activity; phosphatase binding
Biological Process: spermatid differentiation; regulation of interleukin-12 biosynthetic process; phosphorylation; protein amino acid phosphorylation
Reference #:  Q60592 (UniProtKB)
Alt. Names/Synonyms: Mast2; Mast205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2; mKIAA0807; Mtssk
Gene Symbols: Mast2
Molecular weight: 190,534 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Select Structure to View Below

MAST2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 13 S6 __MVTGLSPLLFRKL
0 1 R11 GLSPLLFRKLsNPDI
0 80 S14-p PLLFRKLsNPDIFAP
0 1 P21 sNPDIFAPTGKVKLQ
0 1 T22 NPDIFAPTGKVKLQR
0 27 S32-p VKLQRQLsQDDCKLR
0 3 S42-p DCKLRRGsLASSLSG
0 2 S84 LVRMRNQSLGQsAPs
0 23 S88-p RNQSLGQsAPsLTAG
0 2 S91-p SLGQsAPsLTAGLKE
0 1 S100-p TAGLKELsLPRRGsF
0 3 S106-p LsLPRRGsFCRTSNR
0 1 S121-p KSLIVTSsTsPTLPR
0 2 S123-p LIVTSsTsPTLPRPH
0 1 T125 VTSsTsPTLPRPHsP
0 2 S131-p PTLPRPHsPLHGHTG
0 2 S144-p TGNSPLDsPRNFsPN
0 11 S149-p LDsPRNFsPNAPAHF
0 4 S170-p RTDGRRWsLASLPSS
0 1 T214 ADELHFLTKHFsTEN
0 7 S218-p HFLTKHFsTENVPDE
0 2 T219 FLTKHFsTENVPDEE
0 1 N221 TKHFsTENVPDEEGR
0 10 S230-p PDEEGRRsPRMRPRs
0 8 S237-p sPRMRPRsRsLsPGR
0 31 S239-p RMRPRsRsLsPGRsP
0 29 S241-p RPRsRsLsPGRsPVS
0 1 S245-p RsLsPGRsPVSFDSE
0 1 Y402 IKCDIPRYIVSQLGL
0 1 Y753 ESEDDTSYFDTRSER
0 1 S766 ERYHHVDSEDEEEVS
0 1 S787 IRQFSSCSPRFSKVY
0 1 Y794 SPRFSKVYSsMERLS
0 1 S795 PRFSKVYSsMERLSL
0 7 S796-p RFSKVYSsMERLSLL
0 1 S801 YSsMERLSLLEERRT
0 3 T808 SLLEERRTPPPTKRS
0 1 T812 ERRTPPPTKRSLsEE
0 2 S815 TPPPTKRSLsEEKED
0 5 S817-p PPTKRSLsEEKEDHS
0 1 S824 sEEKEDHSDGLAGLK
0 6 S836-p GLKGRDRsWVIGsPE
0 19 S841-p DRsWVIGsPEILRKR
0 1 S855-p RLSVSESsHTEsDSS
0 1 S859-p SESsHTEsDSSPPMT
0 1 S861 SsHTEsDSSPPMTVR
0 2 S872 MTVRHRCSGLPDGPH
0 1 S931 EEPPGQSSRCCPALE
0 1 C933 PPGQSSRCCPALETR
0 1 C934 PGQSSRCCPALETRG
0 6 R942-m1 PALETRGrGTPQLAE
0 1 P945 ETRGrGTPQLAEEAT
0 57 S970-p RARHRLLsGDsIEKR
0 9 S973-p HRLLsGDsIEKRTTR
0 1 S988-p PVNKVIKsASATALS
0 1 S1023-p SQSSNPSsRDSSPSR
0 1 S1118 VVELVLKSGNKVSIS
0 1 K1121 LVLKSGNKVSISTTP
0 1 S1133 TTPLENTSIKVGPAR
0 1 K1135 PLENTSIKVGPARKG
0 12 K1141 IKVGPARKGSYKAKM
0 2 K1145 PARKGSYKAKMARRS
0 11 K1147 RKGSYKAKMARRSKR
0 2 S1178-p RKITKQAsLLHTSRs
0 1 S1185-p sLLHTSRsLSSLNRS
0 2 S1194-p SSLNRSLssGESGPG
0 1 S1195-p SLNRSLssGESGPGs
0 1 S1202-p sGESGPGsPTHSHSL
0 1 S1213 SHSLSPRSPPQGYRV
0 4 S1275-p YRSPRRKsAGSIPLS
0 1 S1278 PRRKsAGSIPLSPLA
0 1 T1287 PLSPLAHTPSPPATA
0 1 S1289 SPLAHTPSPPATAAS
0 1 S1300-p TAASPQRsPsPLSGH
0 3 S1302-p ASPQRsPsPLSGHGS
0 8 S1319-p FPTKLHLsPPLGRQL
0 3 S1331 RQLSRPKSAEPPRsP
1 5 S1337-p KSAEPPRsPLLKRVQ
0 3 S1345-p PLLKRVQsAEKLAAA
0 1 S1363 AEKKLAPSRKHsLDL
0 9 S1367-p LAPSRKHsLDLPHGE
0 2 G1373 HsLDLPHGELKKELT
0 1 S1385 ELTPREASPLEVVGT
0 3 S1441-p EAIREVDssEDDtDE
0 3 S1442-p AIREVDssEDDtDEE
0 2 T1446-p VDssEDDtDEEPENS
0 2 S1462-p ATQEPRLsPHPEASH
0 1 T1502 PVLSGLVTGATLGSP
0 1 T1505 SGLVTGATLGSPRVD
0 2 S1522-p GLSPRKVsRPQAFEE
0 1 C1568 TQALTALCPSFSELT
0 1 - gap
0 1 S1586-p CSAATSTsGKPGTWS
0 1 F1596 PGTWSWKFLIEGPDR
0 3 S1605-p IEGPDRAsTNKTITR
0 1 - under review  
0 1 S1700-p PCRAHPLsPETRPSL
0 1 T1703 AHPLsPETRPSLLWK
0 1 S1706 LsPETRPSLLWKsQE
0 1 S1711-p RPSLLWKsQELGGQQ
0 1 T1734 SDELLKQT_______
  MAST2 iso3  
R49 GRQLLEERSGPLGHD
R58 GPLGHDSREQDMVTG
S67-p QDMVTGLsPLLFRKL
R72 GLsPLLFRKLSNPDI
S75 PLLFRKLSNPDIFAP
P82 SNPDIFAPTGKVKLQ
T83 NPDIFAPTGKVKLQR
S93 VKLQRQLSQDDCKLR
S103 DCKLRRGSLASSLSG
S145 LVRMRNQSLGQSAPS
S149 RNQSLGQSAPSLTAG
S152 SLGQSAPSLTAGLKE
S161 TAGLKELSLPRRGSF
S167 LSLPRRGSFCRTSNR
S182 KSLIVTSSTSPTLPR
S184 LIVTSSTSPTLPRPH
T186 VTSSTSPTLPRPHSP
S192 PTLPRPHSPLHGHTG
S205 TGNSPLDSPRNFSPN
S210 LDSPRNFSPNAPAHF
S238 RTDGRRWSLASLPSS
T282 ADELHFLTKHFSTEN
S286 HFLTKHFSTENVPDE
T287 FLTKHFSTENVPDEE
N289 TKHFSTENVPDEEGR
S298 PDEEGRRSPAMRPRS
S305 SPAMRPRSRSLSPGR
S307 AMRPRSRSLSPGRSP
S309 RPRSRSLSPGRSPVS
S313 RSLSPGRSPVSFDSE
Y469 IKCDIPRYIVSQLGL
Y820 ESEDDTSYFDTRSER
S833 ERYHHVDSEDEEEVS
S854 IRQFSSCSPRFSKVY
Y861 SPRFSKVYSSMERLS
S862 PRFSKVYSSMERLSL
S863 RFSKVYSSMERLSLL
S868 YSSMERLSLLEERRT
T875 SLLEERRTPPPTKRS
T879 ERRTPPPTKRSLSEE
S882 TPPPTKRSLSEEKED
S884 PPTKRSLSEEKEDHS
S891 SEEKEDHSDGLAGLK
S903 GLKGRDRSWVIGSPE
S908 DRSWVIGSPEILRKR
S922 RLSVSESSHTESDSS
S926 SESSHTESDSSPPMT
S928 SSHTESDSSPPMTVR
S939 MTVRHRCSGLPDGPH
S998 EEPPGQSSRCCPALE
C1000 PPGQSSRCCPALETR
C1001 PGQSSRCCPALETRG
R1009 PALETRGRGTPQLAE
P1012 ETRGRGTPQLAEEAT
S1037 RARHRLLSGDSIEKR
S1040 HRLLSGDSIEKRTTR
S1055 PVNKVIKSASATALS
S1090 SQSSNPSSRDSSPSR
S1185 VVELVLKSGNKVSIS
K1188 LVLKSGNKVSISTTP
S1200 TTPLENTSIKVGPAR
K1202 PLENTSIKVGPARKG
K1208 IKVGPARKGSYKAKM
K1212 PARKGSYKAKMARRS
K1214 RKGSYKAKMARRSKR
S1245 RKITKQASLLHTSRS
S1252 SLLHTSRSLSSLNRS
S1261 SSLNRSLSSGESGPG
S1262 SLNRSLSSGESGPGS
S1269 SGESGPGSPTHSHSL
S1280 SHSLSPRSPPQGYRV
S1341 YRSPRRKSAGSIPLS
S1344 PRRKSAGSIPLSPLA
T1353 PLSPLAHTPSPPATA
S1355 SPLAHTPSPPATAAS
S1366 TAASPQRSPSPLSGH
S1368 ASPQRSPSPLSGHGS
S1385 FPTKLHLSPPLGRQL
S1397 RQLSRPKSAEPPRSP
S1403 KSAEPPRSPLLKRVQ
S1411 PLLKRVQSAEKLAAA
S1429 AEKKLAPSRKHSLDL
S1433 LAPSRKHSLDLPHGE
G1439 HSLDLPHGELKKELT
S1451 ELTPREASPLEVVGT
S1507 EAIREVDSSEDDTDE
S1508 AIREVDSSEDDTDEE
T1512 VDSSEDDTDEEPENS
S1528 ATQEPRLSPHPEASH
T1568 PVLSGLVTGATLGSP
T1571 SGLVTGATLGSPRVD
S1588 GLSPRKLSRPQAFEE
C1634 TQALTALCPSFSELT
- gap
S1652 CSAATSTSGKPGTWS
F1662 PGTWSWKFLIEGPDR
S1671 IEGPDRASTNKTITR
S1700 PNLLKNLSPEEEKPQ
S1766 PCRAHPLSPETRPSL
T1769 AHPLSPETRPSLLWK
S1772 LSPETRPSLLWKSQE
S1777 RPSLLWKSQELGGQQ
T1800 SDELLKQT_______
  human

 
R48 GRQRLEERTGPAGPE
K57 GPAGPEGKEQDVVTG
S66-p QDVVTGVsPLLFRKL
R71 GVsPLLFRKLsNPDI
S74-p PLLFRKLsNPDIFSs
S81-p sNPDIFSstGKVKLQ
T82-p NPDIFSstGKVKLQR
S92-p VKLQRQLsQDDCKLW
N102 DCKLWRGNLASSLSG
S144-p LVRMRNQsLGQsAPs
S148-p RNQsLGQsAPsLTAG
S151-p sLGQsAPsLTAGLKE
S160-p TAGLKELsLPRRGSF
S166 LsLPRRGSFCRTSNR
S181 KSLIVTSSTsPtLPR
S183-p LIVTSSTsPtLPRPH
T185-p VTSSTsPtLPRPHsP
S191-p PtLPRPHsPLHGHTG
S204-p TGNSPLDsPRNFsPN
S209-p LDsPRNFsPNAPAHF
S230-p RTDGRRWsLASLPSS
T274-p ADELHFLtKHFstEs
S278-p HFLtKHFstEsVPDE
T279-p FLtKHFstEsVPDEE
S281-p tKHFstEsVPDEEGR
S290-p PDEEGRQsPAMRPRs
S297-p sPAMRPRsRsLsPGR
S299-p AMRPRsRsLsPGRsP
S301-p RPRsRsLsPGRsPVS
S305-p RsLsPGRsPVSFDSE
Y461-p IKCDIPRyIVSQLGL
Y812-p ESEDDTSyFDTRSER
S825-p ERYHHMDsEDEEEVS
S846-p IRQFSSCsPRFNKVy
Y853-p sPRFNKVyssMERLs
S854-p PRFNKVyssMERLsL
S855-p RFNKVyssMERLsLL
S860-p yssMERLsLLEERRt
T867-p sLLEERRtPPPtKRs
T871-p ERRtPPPtKRsLsEE
S874-p tPPPtKRsLsEEKED
S876-p PPtKRsLsEEKEDHs
S883-p sEEKEDHsDGLAGLK
S895-p GLKGRDRsWVIGsPE
S900-p DRsWVIGsPEILRKR
S914 RLSVSESSHTESDsS
S918 SESSHTESDsSPPMT
S920-p SSHTESDsSPPMTVR
S931-p MTVRRRCsGLLDAPR
S993-p EEAVGRSsGssPAME
S995-p AVGRSsGssPAMETR
S996-p VGRSsGssPAMETRG
R1004-m1 PAMETRGrGTsQLAE
S1007-p ETRGrGTsQLAEGAT
S1032-p RARHRLLsGDSTEKR
S1035 HRLLsGDSTEKRTAR
S1050 PVNKVIKSASATALS
S1085 SQSSNPSSRDSSPSR
S1180-p VVELILKsGNkVAIS
K1183-ub LILKsGNkVAISTTP
S1195-p TTPLENTsIkVGPAR
K1197-ub PLENTsIkVGPARkG
K1203-ac IkVGPARkGSYkAkM
K1207-ac PARkGSYkAkMARRS
K1209-ac RkGSYkAkMARRSKR
S1240-p RKITKQAsLLHTSRS
S1247 sLLHTSRSLSSLNRS
S1256-p SSLNRSLsSGESGPG
S1257 SLNRSLsSGESGPGS
S1264 SGESGPGSPTHSHSL
S1275-p SHSLSPRsPTQGYRV
S1337-p YRSPRRKsAGsIPLS
S1340-p PRRKsAGsIPLSPLA
T1349-p PLSPLAHtPsPPPPT
S1351-p SPLAHtPsPPPPTAS
S1362 PTASPQRSPsPLSGH
S1364-p ASPQRSPsPLSGHVA
S1381-p FPTKLHLsPPLGRQL
S1393-p RQLSRPKsAEPPRsP
S1399-p KsAEPPRsPLLKRVQ
S1407-p PLLKRVQsAEKLAAA
S1425-p SEKKLATsRKHsLDL
S1429-p LATsRKHsLDLPHsE
S1435-p HsLDLPHsELKKELP
S1447-p ELPPREVsPLEVVGA
S1503-p EAIREVDssEDDTEE
S1504-p AIREVDssEDDTEEG
T1508 VDssEDDTEEGPENS
A1524 GAQELSLAPHPEVSQ
T1564-p PMVPSLLtGItLGPP
T1567-p PSLLtGItLGPPRME
G1584 SGPHRRLGSPQAIEE
S1631-p TQALTALsPSTSGLT
S1642-p SGLTPTSsCSPPSST
S1650 CSPPSSTSGKLSMWS
S1660-p LSMWSWKsLIEGPDR
S1669-p IEGPDRAsPSRKATM
S1698-p PAQPKNLsPREQGKT
T1765 PCRGCPLTQKsEPsL
S1768-p GCPLTQKsEPsLRRG
S1771-p LTQKsEPsLRRGQEP
G1775 sEPsLRRGQEPGGHQ
T1798-p PDELLKQt_______
  rat

 
R49-m1 GRQLLEErSGPMGHD
R58-m1 GPMGHDSrEQDMVSG
S67 QDMVSGLSPLLFrKL
R72-m1 GLSPLLFrKLsNPDI
S75-p PLLFrKLsNPDIFSP
P82 sNPDIFSPTGKAKLQ
T83 NPDIFSPTGKAKLQR
S93 AKLQRQLSQDDCKLR
S103 DCKLRRGSLASSLSG
S145 LVRMRNQSLGQSAPS
S149 RNQSLGQSAPSLTAG
S152 SLGQSAPSLTAGLKE
S161-p TAGLKELsLPRRGSF
S167 LsLPRRGSFCRTSNR
S182 KSLIVTSSTSPTLPR
S184 LIVTSSTSPTLPRPH
T186 VTSSTSPTLPRPHSP
S192 PTLPRPHSPLHGHTG
S205 TGNSPLDSPRNFSPN
S210 LDSPRNFSPNAPAHF
S238 RTDGRRWSLASLPSS
T282 ADELHFLTKHFSTEN
S286 HFLTKHFSTENVPDE
T287 FLTKHFSTENVPDEE
N289 TKHFSTENVPDEEGR
S298 PDEEGRQSPAMRPRs
S305-p SPAMRPRsRsLsPGR
S307-p AMRPRsRsLsPGRSP
S309-p RPRsRsLsPGRSPVS
S313 RsLsPGRSPVSFDSE
Y469 IKCDIPRYIVSQLGL
Y820 ESEDDTSYFDTRSER
S833 ERYHHVDSEDEEEVS
S854 IRQFSSCSPRFSKVY
Y861 SPRFSKVYSSMERLS
S862 PRFSKVYSSMERLSL
S863 RFSKVYSSMERLSLL
S868 YSSMERLSLLEGHRT
T875 SLLEGHRTPPPTKRS
T879 GHRTPPPTKRSLsEE
S882 TPPPTKRSLsEEKED
S884-p PPTKRSLsEEKEDHS
S891 sEEKEDHSDGLAGLK
S903 GLKGRDRSWVIGsPE
S908-p DRSWVIGsPEILRKR
S922 RLSVSESSHTESDSS
S926 SESSHTESDSSPPMT
S928 SSHTESDSSPPMTVR
S938 PMTVRHRSGLPDVPR
S997 EEPPGQSSRSCPAME
S999 PPGQSSRSCPAMETR
C1000 PGQSSRSCPAMETRG
R1008 PAMETRGRGTPQLAE
P1011 ETRGRGTPQLAEEAT
S1036-p RARHRLLsGDsIEKR
S1039-p HRLLsGDsIEKRTTR
S1054 PVNKVIKSASATALS
S1089 SQSSNPSSRDSSPSR
S1184 VVELVLKSGNKVSIS
K1187 LVLKSGNKVSISTTP
S1199 TTPLENTSIKVGPAR
K1201 PLENTSIKVGPARKG
K1207 IKVGPARKGSSKAKM
K1211 PARKGSSKAKMARRS
K1213 RKGSSKAKMARRSKR
S1244 RKITKQASLLHTSRS
S1251 SLLHTSRSLSSLNRS
S1260 SSLNRSLSSGESGPC
S1261 SLNRSLSSGESGPCS
S1268 SGESGPCSPTHSHSL
S1279 SHSLSPRSPPQGYRV
S1340 YRSPRRKSAGSIPLS
S1343 PRRKSAGSIPLSPLA
T1352 PLSPLAHTPSPPAAA
S1354 SPLAHTPSPPAAAAS
S1365 AAASPQRSPSPLSGH
S1367 ASPQRSPSPLSGHGS
S1384-p FPTKLHLsPPLGRQL
S1396 RQLSRPKSAEPPRSP
S1402 KSAEPPRSPLLKRVQ
S1410 PLLKRVQSAEKLAAA
S1428 AEKKLAPSRKHSLDL
S1432 LAPSRKHSLDLPHGE
G1438 HSLDLPHGELKKELT
N1450 ELTPREANPLEVVGT
S1506 EAIREVDSSEDDTDE
S1507 AIREVDSSEDDTDEE
T1511 VDSSEDDTDEEPENS
S1527 ATQEPRLSPHPEASQ
T1567 PVLSGLLTGNRIEVP
T1570 under review
W1582 GLSQRKLWRPQAFEE
H1628 TQALATLHPSSSELT
S1638 SSELTPTSCSAATST
S1646 CSAATSTSGKPGTWS
F1656 PGTWSWKFLIEGPDR
S1665 IEGPDRASTNKKITR
- under review  
S1761 PCRAHHLSPETRPSL
T1764 AHHLSPETRPSLLWR
S1767 LSPETRPSLLWRSQE
S1772 RPSLLWRSQELGGQQ
T1795 SDELLKQT_______
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