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PIAS3 (human)

Overview PIAS3 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family. Note: This description may include information from UniProtKB. Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system Cellular Component: dendrite; cytoplasm; synapse; nucleus Molecular Function: protein C-terminus binding; protein binding; potassium channel regulator activity; enzyme binding; nucleic acid binding; zinc ion binding; protein N-terminus binding; SUMO ligase activity Biological Process: positive regulation of protein sumoylation; protein sumoylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to hormone stimulus; positive regulation of membrane potential Reference #:  Q9Y6X2 (UniProtKB) Alt. Names/Synonyms: E3 SUMO-protein ligase PIAS3; FLJ14651; PIAS3; Protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5; ZMIZ5 Gene Symbols: PIAS3 Molecular weight: 68,017 Da Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states CST Pathways:  Jak/Stat/IL-6 Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PIAS3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K307-u	SRALIKEkLTADPDS
0	1		S404	IQFMEDGSWCPMKPK
0	1		A602	SIVAPGGALREGHGG

	mouse
K307	SRALIKEKLTADPDS
S404-p	IQFMEDGsWCPMKPK
S602	SIVAPGSSLREGHGG

	rat
K307	SRALIKEKLTADPDS
S404	IQFMEDGSWCPMKPK
S602-p	SIVAPGSsLREGHGG

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