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PAX8 (human)

Overview PAX8 Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: nucleoplasm; nucleolus; nucleus Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity Biological Process: anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; ureteric bud branching; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; urogenital system development Reference #:  Q06710 (UniProtKB) Alt. Names/Synonyms: paired box 8; Paired box protein Pax-8; paired domain gene 8; PAX8 Gene Symbols: PAX8 Molecular weight: 48,218 Da Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAX8 2K27 - A=1-143 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 167415 218700  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T279	DDGKATLTPSNTPLG
0	1		S290	TPLGRNLSTHQTYPV
0	2		S303	PVVADPHSPFAIKQE
1	0		K308	PHSPFAIKQETPEVS

	mouse
T280	DDGKATLTSSNTPLG
S291-p	TPLGRNLsTHQTYPV
S304-p	PVVADPHsPFAIkQE
K309-s	PHsPFAIkQETPELS

	rat
T280-p	DDGKATLtPSNTPLG
S291	TPLGRNLSTHQTYPV
S304	PVVADPHSPYAIKQE
K309	PHSPYAIKQETPELS

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