Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity
Biological Process: regulation of apoptosis; inner ear morphogenesis; anatomical structure morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; urogenital system development; pronephros development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.