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Protein Page:
PAX8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAX8 Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity
Biological Process: inner ear morphogenesis; anatomical structure morphogenesis; central nervous system development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; ureteric bud branching; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; urogenital system development
Reference #:  Q06710 (UniProtKB)
Alt. Names/Synonyms: paired box 8; Paired box protein Pax-8; paired domain gene 8; PAX8
Gene Symbols: PAX8
Molecular weight: 48,218 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAX8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T279 DDGKATLTPSNTPLG
0 1 S290 TPLGRNLSTHQTYPV
0 4 S303-p PVVADPHsPFAIKQE
1 0 K308 PHsPFAIKQETPEVS
  mouse

 
T280 DDGKATLTSSNTPLG
S291-p TPLGRNLsTHQTYPV
S304-p PVVADPHsPFAIkQE
K309-sm PHsPFAIkQETPELS
  rat

 
T280-p DDGKATLtPSNTPLG
S291 TPLGRNLSTHQTYPV
S304 PVVADPHSPYAIKQE
K309 PHSPYAIKQETPELS
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