Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; sulfur metabolic process; ureteric bud branching; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; urogenital system development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.