Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Transcription factor; C2H2-type zinc finger protein; DNA binding protein
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; androgen receptor binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of monocyte differentiation; macrophage activation; monocyte activation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; response to lipopolysaccharide; regulation of tumor necrosis factor production; osteoclast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis; endothelial cell activation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.