Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; C2H2-type zinc finger protein; Cell cycle regulation
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; chromatin binding; DNA bending activity; transcription factor activity
Biological Process: skeletal muscle development; transcription, DNA-dependent; immunoglobulin V(D)J recombination; pattern specification process; cardiac muscle cell differentiation; smooth muscle development; positive regulation of immunoglobulin production; pre-B cell differentiation; embryonic development; positive regulation of mesenchymal cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.