Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein; Cell cycle regulation; Transcription factor
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; chromatin binding; transcription factor activity; DNA bending activity
Biological Process: smooth muscle development; skeletal muscle development; pre-B cell differentiation; positive regulation of immunoglobulin production; transcription, DNA-dependent; immunoglobulin V(D)J recombination; positive regulation of mesenchymal cell proliferation; negative regulation of transcription, DNA-dependent; pattern specification process; cardiac muscle cell differentiation; positive regulation of epithelial cell proliferation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.