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Protein Page:
FOXP1 (human)

Overview
FOXP1 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; C2H2-type zinc finger protein; Cell cycle regulation
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; chromatin binding; DNA bending activity; transcription factor activity
Biological Process: skeletal muscle development; transcription, DNA-dependent; immunoglobulin V(D)J recombination; pattern specification process; cardiac muscle cell differentiation; smooth muscle development; positive regulation of immunoglobulin production; pre-B cell differentiation; embryonic development; positive regulation of mesenchymal cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; lung development
Reference #:  Q9H334 (UniProtKB)
Alt. Names/Synonyms: 12CC4; FLJ23741; fork head-related protein like B; forkhead box P1; Forkhead box protein P1; FOXP1; glutamine-rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF1
Gene Symbols: FOXP1
Molecular weight: 75,317 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXP1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S37 GGLREGRSNGETPAV
0 6 S83-p QQVSGLKsPKRNDKQ
0 1 N247 TAEETTGNNHSSLDL
0 1 T256 HSSLDLTTTCVSSSA
0 1 T257 SSLDLTTTCVSSSAP
0 4 S440-p GPIRRRYsDKYNVPI
0 2 S615-p GAMEHTNsNEsDSSP
0 3 S618-p EHTNsNEsDSSPGRs
0 7 S625-p sDSSPGRsPMQAVHP
0 1 S650 EEAEGPLSLVTTANH
0 1 S658-p LVTTANHsPDFDHDR
  mouse

 
S37-p GALRDTRsNGEAPAV
S113-p QQVSGLKsPKRNDKQ
S275 TAEETTSSNHSSLDL
S284 HSSLDLTSTCVSSSA
T285 SSLDLTSTCVSSSAP
S468-p GPIRRRYsDKYNVPI
S643 GAMEHTNSNESDSSP
S646 EHTNSNESDSSPGRS
S653 SDSSPGRSPMQAVHP
S678-p EEAEGPLsLVTTANH
S686-p LVTTANHsPDFDHDR
  rat

 
S37 GTLRDTRSNGEAPAV
S115 QQVSGLKSPKRNDKQ
S281-p TAEETTGsNHSSLDL
S290-p HSSLDLTstCVSSSA
T291-p SSLDLTstCVSSSAP
S474 GPIRRRYSDKYNVPI
S649 GAMEHTNSNESDSSP
S652 EHTNSNESDSSPGRS
S659 SDSSPGRSPMQAVHP
S684 EEAEGPLSLVTTANH
S692 LVTTANHSPDFDHDR
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