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CYBA (human)

Overview CYBA Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; EC 1.-.-.-; Oxidoreductase Cellular Component: Golgi apparatus; phagocytic vesicle membrane; mitochondrion; cell soma; dendrite; apical plasma membrane; secretory granule; NADPH oxidase complex Molecular Function: protein binding; electron carrier activity; protein heterodimerization activity; metal ion binding; superoxide-generating NADPH oxidase activity; heme binding; SH3 domain binding Biological Process: respiratory burst; response to nutrient levels; response to drug; interaction with host; angiotensin-mediated regulation of glomerular filtration; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; antigen processing and presentation of peptide antigen via MHC class I; cytochrome complex assembly; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; smooth muscle hypertrophy; positive regulation of endothelial cell proliferation; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process Reference #:  P13498 (UniProtKB) Alt. Names/Synonyms: CY24A; CYBA; cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit Gene Symbols: CYBA Molecular weight: 21,013 Da Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states

Select Structure to View Below CYBA 1WLP - A=144-168 (human)

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	Sites Implicated In
enzymatic activity, induced: T147‑p molecular association, regulation: T147‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K60-u	EYPRGKRkkGSTMER
0	5		K61-u	YPRGKRkkGSTMERW
0	5		K71-u	TMERWGQkyMTAVVk
0	1		Y72-p	MERWGQkyMTAVVkL
0	1		K78-u	kyMTAVVkLFGPFTR
0	1		Y87-p	FGPFTRNyyVRAVLH
0	1		Y88-p	GPFTRNyyVRAVLHL
0	7		K137-u	QWTPIEPkPRERPQI
0	1		R139	TPIEPkPRERPQIGG
1	7		T147-p	ERPQIGGtIkQPPSN
0	11		K149-u	PQIGGtIkQPPSNPP
0	3		S168-p	AEARKKPsEEEAAVA
0	3		A176	EEEAAVAAGGPPGGP

	mouse
K60	EYPRGKRKKGSTMER
K61	YPRGKRKKGSTMERC
K71	TMERCGQKYLTSVVK
Y72	MERCGQKYLTSVVKL
K78	KYLTSVVKLFGPLTR
Y87	FGPLTRNYYVRAALH
Y88	GPLTRNYYVRAALHF
K137	QWTPIEPKPkERPQV
K139-u	TPIEPKPkERPQVGG
T147-p	ERPQVGGtIkQPPTN
K149-u	PQVGGtIkQPPTNPP
S168-p	AEVRKKPsEGEEEAA
S176-p	EGEEEAAsAGGPQVN

	rat
K60	EYPRGKRKKGSTMER
K61	YPRGKRKKGSTMERC
K71	TMERCGQKYLTAVVK
Y72	MERCGQKYLTAVVKL
K78	KYLTAVVKLFGPLTR
Y87	FGPLTRNYYVRAVLH
Y88	GPLTRNYYVRAVLHL
K137	QWTPIEPKPKERPQV
K139	TPIEPKPKERPQVGG
T147-p	ERPQVGGtIKQPPTN
K149	PQVGGtIKQPPTNPP
S168	AEVRKKPSEAEEEAA
S176	EAEEEAASAGGPQVN

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