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BMP7 (human)

Overview BMP7 Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: extracellular space Molecular Function: protein binding; growth factor activity; cytokine activity Biological Process: axon guidance; negative regulation of MAP kinase activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; negative regulation of cell cycle; negative regulation of neurogenesis; BMP signaling pathway; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; epithelial to mesenchymal transition; negative regulation of phosphorylation; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; metanephros development; neurite morphogenesis; growth Reference #:  P18075 (UniProtKB) Alt. Names/Synonyms: BMP-7; BMP7; Bone morphogenetic protein 7; OP-1; OP1; Osteogenic protein 1 Gene Symbols: BMP7 Molecular weight: 49,313 Da Basal Isoelectric point: 7.74  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling

Select Structure to View Below BMP7 1BMP - A=293-431 (human) 1LX5 - A=293-431 (human) 1LXI - A=293-431 (human) 1M4U - L=293-431 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BMP 1LX5 1LXI 1M4U  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K162-u	EFRFDLSkIPEGEAV
0	1		T306-p	RSQNRSKtPKNQEAL
0	1		S322-p	MANVAENssSDQRQA
0	1		S323-p	ANVAENssSDQRQAC

	mouse
K161	EFRFDLSKIPEGEAV
T305	RSQNRSKTPKNQEAL
S321	MASVAENSSSDQRQA
S322	ASVAENSSSDQRQAC

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