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Protein Page:
CARD14 (human)

Overview
CARD14 a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm; plasma membrane
Molecular Function: CARD domain binding
Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of apoptosis
Reference #:  Q9BXL6 (UniProtKB)
Alt. Names/Synonyms: bcl10-interacting maguk protein 2; BIMP2; CAR14; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; card-maguk protein 2; CARD14; Carma 2; CARMA2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14
Gene Symbols: CARD14
Molecular weight: 113,270 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below

CARD14

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p GELCRRDsALTALDE
0 1 Y227-p RSLQEELyLLKQELQ
0 1 S276 EENEKLRSLTFSLAE
0 1 S280 KLRSLTFSLAEKDIL
0 1 S474-p LVDSFRSsSPAPPSQ
0 1 S544-p ESSLQPVsPGRLDVS
0 1 S763-p CTVTRKPssGGPQKL
0 1 S764-p TVTRKPssGGPQKLV
0 2 S775-p QKLVRIVsMDKAKAS
0 1 T944-p KGLQRLGtSEEQLLE
  mouse

 
S9 AELCRMDSTLTALDE
Y227 HSLQEELYLVKQELQ
S276-p EENEKLRsMTFsLVE
S280-p KLRsMTFsLVEKDIL
S474 QMDSFRSSSPMPPSQ
S542 EDSLQGSSRSLNVSE
P759 CTVPRKPPGGPQKLV
- gap
S770 QKLVRIVSVDKAAVS
S940 KGLHRLGSSEEQFLE
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