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Protein Page:
DLL4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DLL4 Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral
Cellular Component: integral to membrane; plasma membrane
Molecular Function: calcium ion binding; Notch binding
Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; blood circulation; Notch receptor processing; blood vessel remodeling; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction
Reference #:  Q9NR61 (UniProtKB)
Alt. Names/Synonyms: delta 4; delta ligand 4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; Delta-like protein 4; Delta4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4
Gene Symbols: DLL4
Molecular weight: 74,605 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLL4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K576 NNLSDFQKDNLIPAA
  mouse

 
K577-u NNLSDFQkDNLIPAA
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