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Protein Page:
MFN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MFN1 Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Belongs to the mitofusin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Mitochondrial; Hydrolase; EC 3.6.5.-; Membrane protein, integral
Cellular Component: mitochondrial outer membrane; integral to membrane
Molecular Function: GTPase activity; protein binding; GTP binding
Biological Process: mitochondrial fusion; GTP catabolic process
Reference #:  Q8IWA4 (UniProtKB)
Alt. Names/Synonyms: DKFZp762F247; FLJ20693; Fzo homolog; hfzo1; hfzo2; MFN1; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; mitofusin 1; Mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1
Gene Symbols: MFN1
Molecular weight: 84,100 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MFN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MAEPVsPLkHFVL
0 1 K9-ub AEPVsPLkHFVLAKK
0 1 K61-ub LVEMQGYkDkLSIIG
0 3 K63-ub EMQGYkDkLSIIGEV
0 2 K133-ub MTEGSDEkKSVKTVN
0 2 K150-ub AHALHMDkDLkAGCL
0 1 K153-ub LHMDkDLkAGCLVRV
0 2 K229-ub KVNERLSkPNIFILN
0 2 K336-ub SQSAVKTkFEQHTIR
0 1 K345-ub EQHTIRAkQILATVK
0 1 K365-ub VNLAAEDkRHYSVEE
0 4 K395-ub NLLTLDVkkKIKEVT
0 1 K396 LLTLDVkKKIKEVTE
0 2 K396-ub LLTLDVkkKIKEVTE
0 1 K397 LTLDVkkKIKEVTEE
0 1 K399 LDVkkKIKEVTEEVA
0 7 K439-ub HPNPDVLkIYkSELN
0 3 K442-ub PDVLkIYkSELNkHI
0 1 K447-ub IYkSELNkHIEDGMG
0 1 K500-ub HTLIPCKkFDLSYNL
0 3 K653-ub FVNYATEkLRMIVSS
0 1 T687-p LCQQVDItQKQLEEE
0 1 K718-ub NSKLLRNkAVQLENE
0 6 K731-ub NELENFTkQFLPSSN
  mouse

 
S6 __MAETVSPLKHFVL
K9 AETVSPLKHFVLAKK
R61 LVEIQGYRNKLAVIG
K63 EIQGYRNKLAVIGEV
K133-ub MTEGSDEkKSVKTVN
K150 AHALHMDKDLKAGCL
K153 LHMDKDLKAGCLVHV
K229-ub KVNERLSkPNIFILN
K336 SQSAVKTKFEQHTIR
K345 EQHTIRAKQILDTVK
K365 VNVAAAEKRVYSMEE
K395-ub NLLTLDVkkkIkEVT
K396-ac LLTLDVkkkIkEVTE
K396-ub LLTLDVkkkIkEVTE
K397-ac LTLDVkkkIkEVTEE
K399-ub LDVkkkIkEVTEEVA
K439 HPTPSVLKVYKSELN
K442 PSVLKVYKSELNKHI
K447 VYKSELNKHIEDGMG
K500 HTLIPCKKFDLSYDL
K653 FVNYATEKLQMIVSF
T687 LCQQVDVTQKHLEEE
K718 NSKLLRNKAVQLESE
K731 SELENFSKQFLHPSS
  rat

 
S6 __MAETVSPLKHFVL
K9 AETVSPLKHFVLAKK
R61 LVEIQGYRNKLAVIG
K63 EIQGYRNKLAVIGEV
K133 MTEGSDEKKSVKTVN
K150 AHALHMDKDLKAGCL
K153 LHMDKDLKAGCLVHV
K229 KVNERLSKPNIFILN
K336 SQSAVKTKFEQHTIR
K345 EQHTIRAKQILDTVK
K365 VNVAAAEKRVYSMEE
K395 NLLTMDVKKKIKEVT
K396 LLTMDVKKKIKEVTE
K396 LLTMDVKKKIKEVTE
K397 LTMDVKKKIKEVTEE
K399 MDVKKKIKEVTEEVA
K439 HPTPSVLKVYKSELN
K442 PSVLKVYKSELNKHI
K447 VYKSELNKHIEDGMG
K500 HTLIPCKKFDLSYDL
K653 FVNYATEKLQMIVKF
T687 LCQQVDVTQKHLEEE
K718 NSKLLRNKAVQLERE
K731 RELENFSKQFLHPSS
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