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AP-2 gamma (human)

Overview AP-2 gamma Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA binding protein Cellular Component: nucleus Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity Biological Process: skin development; regulation of transcription from RNA polymerase II promoter; cell-cell signaling; hair follicle development; somatic stem cell maintenance; male gonad development; germ-line stem cell maintenance; sebaceous gland development; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development; trophectodermal cell differentiation Reference #:  Q92754 (UniProtKB) Alt. Names/Synonyms: Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C; ERF1; estrogen receptor factor 1; hAP-2g; TFAP2C; TFAP2G; Transcription factor AP-2 gamma; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); Transcription factor ERF-1 Gene Symbols: TFAP2C Molecular weight: 49,177 Da Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AP-2 gamma

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K10-s	WKITDNVkYEEDCED
0	2		S252-p	AEVQRRLsPPECLNA
0	1		R276	AKSKNGGRSLREKLD
0	3		S434-p	YMNPGDQsPADSNKT
0	1		K444-u	DSNKTLEkMEkHRK_
0	1		K447-u	KTLEkMEkHRK____

	mouse
K10	WKITDNVKYEEDCED
S251-p	AEVQRRLsPPECLNA
R275-m1	AKSKNGGrSLREKLD
S433	YMNPGDQSPADSSKT
K443	DSSKTMEKMEKHRK_
K446	KTMEKMEKHRK____

	rat
K10	WKITDNVKYEEDCED
S252	AEVQRRLSPPECLNA
R276	AKSKNGGRSLREKLD
S434	YMNPGEQSPADSNKT
K444	DSNKTMEKMEKHRK_
K447	KTMEKMEKHRK____

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