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Protein Page:
TCF7 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TCF7 Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. By TCF7L2 and CTNNB1. Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. Belongs to the TCF/LEF family. 16 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor activity
Biological Process: neural tube development; transcription, DNA-dependent; alpha-beta T cell differentiation; Wnt receptor signaling pathway through beta-catenin; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; generation of neurons; embryonic digestive tract morphogenesis; T cell receptor V(D)J recombination; immune response; brain development; embryonic genitalia morphogenesis; embryonic hindgut morphogenesis
Reference #:  P36402 (UniProtKB)
Alt. Names/Synonyms: FLJ36364; MGC47735; T-cell factor 1; T-cell-specific transcription factor 1; TCF-1; TCF-7; TCF1; TCF7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor-7, T-cell specific
Gene Symbols: TCF7
Molecular weight: 41,642 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCF7

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S161-p PHGVPQLsLyEHFNs
0 36 Y163-p GVPQLsLyEHFNsPH
0 3 S168-p sLyEHFNsPHPTPAP
0 8 K253-u QPFDRNLkTQAESkA
0 3 K259-u LkTQAESkAEKEAKK
0 8 K317-u LSREEQAkYYELARK
0 12 Y333-p RQLHMQLyPGWSARD
  TCF7 iso4  
S46 PHGVPQLSLYEHFNS
Y48 GVPQLSLYEHFNSPH
S53 SLYEHFNSPHPTPAP
K138 QPFDRNLKTQAESKA
K144 LKTQAESKAEKEAKK
K202 LSREEQAKYYELARK
Y218 RQLHMQLYPGWSARD
  TCF7 iso10  
S46 PHGVPQLSLYEHFNS
Y48 GVPQLSLYEHFNSPH
S53 SLYEHFNSPHPTPAP
K138-u QPFDRNLkTQAESKA
K144 LkTQAESKAEKEAKK
K202 LSREEQAKYYELARK
Y218 RQLHMQLYPGWSARD
  mouse

 
S163 PHGVPQLSPLYEHFS
Y166 VPQLSPLYEHFSSPH
S171 PLYEHFSSPHPTPAP
K288 QPYDRNLKTQAEPKA
K294 LKTQAEPKAEKEAKK
K352 LSREEQAKYYELARK
Y368 RQLHMQLYPGWSARD
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