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Oct7 (human)

Overview Oct7 Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; DNA binding protein; Transcription factor Cellular Component: transcription factor complex Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: neuron differentiation; epidermis development; neurohypophysis development; positive regulation of cell proliferation; cerebral cortex radially oriented cell migration; hypothalamus cell differentiation; positive regulation of multicellular organism growth; regulation of axonogenesis; astrocyte development; forebrain ventricular zone progenitor cell division; myelination in the peripheral nervous system Reference #:  P20265 (UniProtKB) Alt. Names/Synonyms: Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; BRN2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; OCT7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; OTF7; PO3F2; POU class 3 homeobox 2; POU domain, class 3, transcription factor 2; POU3F2; POUF3 Gene Symbols: POU3F2 Molecular weight: 46,893 Da Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

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	Sites Implicated In
transcription, altered: S360‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S304-p	TLYGNVFsQttICRF
0	1		T306-p	YGNVFsQttICRFEA
0	1		T307-p	GNVFsQttICRFEAL
0	1		S339-p	LEEADSSsGsPTSID
0	2		S341-p	EADSSsGsPTSIDKI
1	0		T359	GRKRKKRTsIEVSVK
2	0		S360-p	RKRKKRTsIEVSVKG
0	1		S429-p	AEDVYGGsRDtPPHH
0	5		T432-p	VYGGsRDtPPHHGVQ
0	4		T440-p	PPHHGVQtPVQ____

	mouse
S306	TLYGNVFSQTTICRF
T308	YGNVFSQTTICRFEA
T309	GNVFSQTTICRFEAL
S341	LEEADSSSGSPTSID
S343	EADSSSGSPTSIDKI
T361-p	GRKRKKRtsIEVSVK
S362-p	RKRKKRtsIEVSVKG
S431	AEDVYGGSRDtPPHH
T434-p	VYGGSRDtPPHHGVQ
T442-p	PPHHGVQtPVQ____

	rat
S306	TLYGNVFSQTTICRF
T308	YGNVFSQTTICRFEA
T309	GNVFSQTTICRFEAL
S341	LEEADSSSGSPTSID
S343	EADSSSGSPTSIDKI
T361	GRKRKKRTSIEVSVK
S362	RKRKKRTSIEVSVKG
S431	AEDVYGGSRDTPPHH
T434	VYGGSRDTPPHHGVQ
T442	PPHHGVQTPVQ____

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