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Protein Page:
Oct7 (human)

Overview
Oct7 Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: transcription factor complex; nucleus
Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: neuron differentiation; epidermis development; neurohypophysis development; transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex radially oriented cell migration; hypothalamus cell differentiation; positive regulation of multicellular organism growth; regulation of axonogenesis; astrocyte development; forebrain ventricular zone progenitor cell division; myelination in the peripheral nervous system
Reference #:  P20265 (UniProtKB)
Alt. Names/Synonyms: Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; BRN2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Oct-7; OCT7; Octamer-binding protein 7; Octamer-binding transcription factor 7; OTF-7; OTF7; PO3F2; POU class 3 homeobox 2; POU domain, class 3, transcription factor 2; POU3F2; POUF3
Gene Symbols: POU3F2
Molecular weight: 46,893 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Oct7

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S339-p LEEADSSsGsPTSID
0 4 S341-p EADSSsGsPTSIDKI
1 0 T359 GRKRKKRTsIEVSVK
2 0 S360-p RKRKKRTsIEVSVKG
0 1 S429-p AEDVYGGsRDtPPHH
0 5 T432-p VYGGsRDtPPHHGVQ
0 4 T440-p PPHHGVQtPVQ____
  mouse

 
S341 LEEADSSSGSPTSID
S343 EADSSSGSPTSIDKI
T361-p GRKRKKRtsIEVSVK
S362-p RKRKKRtsIEVSVKG
S431 AEDVYGGSRDtPPHH
T434-p VYGGSRDtPPHHGVQ
T442-p PPHHGVQtPVQ____
  rat

 
S341 LEEADSSSGSPTSID
S343 EADSSSGSPTSIDKI
T361 GRKRKKRTSIEVSVK
S362 RKRKKRTSIEVSVKG
S431 AEDVYGGSRDTPPHH
T434 VYGGSRDTPPHHGVQ
T442 PPHHGVQTPVQ____
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