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Protein Page:
DYM (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DYM Necessary for correct organization of Golgi apparatus. Involved in bone development. Defects in DYM are the cause of Dyggve-Melchior-Clausen syndrome (DMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation. Electron microscopic study of cutaneous cells of affected patients shows dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles. DMC is progressive. Defects in DYM are the cause of Smith-McCort dysplasia (SMC). SMC is a rare autosomal recessive osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest. The radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a distinctive lacy appearance of the iliac crest, features identical to those of Dyggve-Melchior-Clausen syndrome. Belongs to the dymeclin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: Golgi apparatus; cytoplasm
Molecular Function: protein binding; enzyme binding
Biological Process: Golgi organization and biogenesis
Reference #:  Q7RTS9 (UniProtKB)
Alt. Names/Synonyms: DMC; Dyggve-Melchior-Clausen syndrome protein; DYM; Dymeclin; FLJ20071; FLJ90130; SMC
Gene Symbols: DYM
Molecular weight: 75,935 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Select Structure to View Below

DYM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K13 SRIGDLPKNEYLKKL
0 2 T446-p LILVVIRtIQYNMtR
0 2 T452-p RtIQYNMtRTRDKyL
0 1 Y458-p MtRTRDKyLHTNCLA
0 2 S490-p QRIISLFsLLSKKHN
0 1 K498-u LLSKKHNkVLEQATQ
0 2 K608-u ERVLEIIkQGVVALP
  mouse

 
K13-u SKISDLPkNEYLKKL
T446 LILVVIRTIQYNMtR
T452-p RTIQYNMtRTRDKYL
Y458 MtRTRDKYLHTNCLA
S490-p QRIISLFsLLSKKHN
K498 LLSKKHNKVLEQATQ
K608 ERVLEIIKQGVVALP
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