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Protein Page:
PAK2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAK2 a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKA subfamily
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: transferase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein tyrosine kinase activator activity; kinase activity; protein kinase binding; catalytic activity; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: metabolic process; apoptosis; protein amino acid autophosphorylation; cytokinesis; protein amino acid phosphorylation; regulation of apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of growth; response to stress; mitotic cell cycle; phosphorylation; negative regulation of apoptosis
Reference #:  Q8CIN4 (UniProtKB)
Alt. Names/Synonyms: A130002K10Rik; AI836325; D16Ertd269e; Gamma-PAK; KIAA4182; mKIAA4182; OTTMUSP00000028355; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; PAK-2p27; PAK-2p34; Pak2; Serine/threonine-protein kinase PAK 2
Gene Symbols: Pak2
Molecular weight: 57,930 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAK2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 19 S2-p ______MsDNGELED
1 12 S19 PAPPVRMSstIFSTG
5 105 S20-p APPVRMSstIFSTGG
0 13 T21-p PPVRMSstIFSTGGK
0 1 S24 RMSstIFSTGGKDPL
0 1 T25 MSstIFSTGGKDPLS
0 1 K28 tIFSTGGKDPLSANH
0 6 S32 TGGKDPLSANHSLKP
0 13 S36 DPLSANHSLKPLPsV
0 4 K38 LSANHSLKPLPsVPE
0 25 S42-p HSLKPLPsVPEEKKP
0 1 K52 EEKKPRNKIIsIFSG
1 4 S55-p KPRNKIIsIFSGTEK
0 9 S58 NKIIsIFSGTEKGsK
0 1 G59 KIIsIFSGTEKGsKK
0 3 T60 IIsIFSGTEKGsKKK
0 4 K62 sIFSGTEKGsKKKEK
0 5 S64-p FSGTEKGsKKKEKER
0 1 S75 EKERPEISPPsDFEH
0 1 S78-p RPEISPPsDFEHTIH
0 1 K128 QAVLDVLKFYDsNTV
1 126 Y130 VLDVLKFYDsNTVkQ
0 10 S132-p DVLKFYDsNTVkQKy
0 10 T134 LKFYDsNTVkQKyLs
0 2 K136-ub FYDsNTVkQKyLsFt
1 38 Y139-p sNTVkQKyLsFtPPE
7 123 S141-p TVkQKyLsFtPPEKD
0 47 T143-p kQKyLsFtPPEKDGF
0 1 D148 sFtPPEKDGFPsGtP
0 13 S152-p PEKDGFPsGtPALNt
0 15 T154-p KDGFPsGtPALNtKG
0 4 T159-p sGtPALNtKGSETSA
1 0 S165 NtKGSETSAVVtEED
0 25 T169-p SETSAVVtEEDDDDE
5 0 S192-p PRPDHTKsIYtRsVI
1 13 Y194 PDHTKsIYtRsVIDP
0 5 T195-p DHTKsIYtRsVIDPI
5 18 S197-p TKsIYtRsVIDPIPA
0 1 D212 PVGDSNVDsGAKSSD
0 1 S213-p VGDSNVDsGAKSSDK
0 1 T228 QKKKAKMTDEEIMEk
0 2 K235-ub TDEEIMEkLRTIVSI
0 2 Y252-p PKKKYTRyEKIGQGA
0 1 K254 KKYTRyEKIGQGASG
0 1 K278 LGQEVAIKQINLQKQ
0 2 K299 INEILVMKELKNPNI
0 1 K302 ILVMKELKNPNIVNF
0 12 K370-ub QVIHRDIkSDNVLLG
0 1 S381 VLLGMEGSVKLTDFG
0 1 T394 FGFCAQITPEQSKRs
0 1 K399 QITPEQSKRstMVGt
0 10 K399 QITPEQSKRstMVGt
0 4 S401-p TPEQSKRstMVGtPY
10 11 T402-p PEQSKRstMVGtPYW
0 4 T406-p KRstMVGtPYWMAPE
0 14 Y453 ENPLRALYLIATNGT
0 26 K468 PELQNPEKLSPIFrD
0 1 R474-m2 EKLSPIFrDFLNRCL
0 1 R474 EKLSPIFRDFLNRCL
0 1 R479 IFrDFLNRCLEMDVE
0 1 R488 LEMDVEKRGSAKELL
0 1 S490 MDVEKRGSAKELLQH
0 1 K492 VEKRGSAKELLQHPF
0 8 K492 VEKRGSAKELLQHPF
0 1 S507 LKLAKPLSSLTPLIL
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  human

 
S2-p ______MsDNGELED
S19-p PAPPVRMsstIFstG
S20-p APPVRMsstIFstGG
T21-p PPVRMsstIFstGGk
S24-p RMsstIFstGGkDPL
T25-p MsstIFstGGkDPLs
K28-ac tIFstGGkDPLsANH
S32-p tGGkDPLsANHsLkP
S36-p DPLsANHsLkPLPsV
K38-ac LsANHsLkPLPsVPE
S42-p HsLkPLPsVPEEKKP
K52-ub EEKKPRHkIIsIFsG
S55-p KPRHkIIsIFsGtEk
S58-p HkIIsIFsGtEkGsK
G59 kIIsIFsGtEkGsKK
T60-p IIsIFsGtEkGsKKK
K62-ac sIFsGtEkGsKKKEK
S64-p FsGtEkGsKKKEKER
S75-p EKERPEIsPPSDFEH
S78 RPEIsPPSDFEHTIH
K128-ac QAVLDVLkFyDsNtV
Y130-p VLDVLkFyDsNtVkQ
S132-p DVLkFyDsNtVkQKy
T134-p LkFyDsNtVkQKyLs
K136-ub FyDsNtVkQKyLsFt
Y139-p sNtVkQKyLsFtPPE
S141-p tVkQKyLsFtPPEKd
T143-p kQKyLsFtPPEKdGF
D148-ca sFtPPEKdGFPsGtP
S152-p PEKdGFPsGtPALNA
T154-p KdGFPsGtPALNAKG
A159 sGtPALNAKGTEAPA
P165 NAKGTEAPAVVtEEE
T169-p TEAPAVVtEEEDDDE
S192-p PRPDHTKsIytRsVI
Y194-p PDHTKsIytRsVIDP
T195-p DHTKsIytRsVIDPV
S197-p TKsIytRsVIDPVPA
D212-ca PVGDSHVdGAAKSLD
G213 VGDSHVdGAAKSLDK
T228-p QKKKTKMtDEEIMEk
K235-ub tDEEIMEkLRTIVSI
Y252 PKKKYTRYEkIGQGA
K254-ub KKYTRYEkIGQGASG
K278-ub LGQEVAIkQINLQKQ
K299-ub INEILVMkELkNPNI
K302-ub ILVMkELkNPNIVNF
K370-ub QVIHRDIkSDNVLLG
S381-p VLLGMEGsVKLTDFG
T394-p FGFCAQItPEQSkRs
K399-ac QItPEQSkRstMVGt
K399-ub QItPEQSkRstMVGt
S401-p tPEQSkRstMVGtPY
T402-p PEQSkRstMVGtPYW
T406-p kRstMVGtPYWMAPE
Y453-p ENPLRALyLIATNGT
K468-ub PELQNPEkLSPIFRD
R474 EkLSPIFRDFLNRCL
R474 EkLSPIFRDFLNRCL
R479 IFRDFLNRCLEMDVE
R488 LEMDVEKRGsAkELL
S490-p MDVEKRGsAkELLQH
K492-ac VEKRGsAkELLQHPF
K492-ub VEKRGsAkELLQHPF
S507-p LKLAKPLsSLTPLIM
2607 : Phospho-PAK2 (Ser20) Antibody
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  rat

 
S2-p ______MsDNGELED
S19 PAPPVRMSSTIFSTG
S20 APPVRMSSTIFSTGG
T21 PPVRMSSTIFSTGGK
S24 RMSSTIFSTGGKDPL
T25 MSSTIFSTGGKDPLS
K28 TIFSTGGKDPLSANH
S32 TGGKDPLSANHSLKP
S36 DPLSANHSLKPLPSV
K38 LSANHSLKPLPSVPE
S42 HSLKPLPSVPEEKKP
K52 EEKKPRNKIISIFSs
S55 KPRNKIISIFSsTEK
S58 NKIISIFSsTEKGSK
S59-p KIISIFSsTEKGSKK
T60 IISIFSsTEKGSKKK
K62 SIFSsTEKGSKKKEK
S64 FSsTEKGSKKKEKER
S75 EKERPEISPPSDFEH
S78 RPEISPPSDFEHTIH
K128 QAVLDVLKFYDsNTV
Y130 VLDVLKFYDsNTVKQ
S132-p DVLKFYDsNTVKQKy
T134 LKFYDsNTVKQKyLs
K136 FYDsNTVKQKyLsFt
Y139-p sNTVKQKyLsFtPPE
S141-p TVKQKyLsFtPPEKD
T143-p KQKyLsFtPPEKDGF
D148 sFtPPEKDGFPsGtP
S152-p PEKDGFPsGtPALNT
T154-p KDGFPsGtPALNTKG
T159 sGtPALNTKGSETSA
S165 NTKGSETSAVVTEED
T169 SETSAVVTEEDDDDE
S192 PRPDHTKSIYTRsVI
Y194 PDHTKSIYTRsVIDP
T195 DHTKSIYTRsVIDPI
S197-p TKSIYTRsVIDPIPA
D212 PVGDSNVDSGAKSSD
S213 VGDSNVDSGAKSSDK
T228 QKKKAKMTDEEIMEK
K235 TDEEIMEKLRTIVSI
Y252 PKKKYTRYEKIGQGA
K254 KKYTRYEKIGQGASG
K278 LGQEVAIKQINLQKQ
K299 INEILVMKELKNPNI
K302 ILVMKELKNPNIVNF
K370 QVIHRDIKSDNVLLG
S381 VLLGMEGSVKLTDFG
T394 FGFCAQITPEQSKRs
K399 QITPEQSKRstMVGT
K399 QITPEQSKRstMVGT
S401-p TPEQSKRstMVGTPY
T402-p PEQSKRstMVGTPYW
T406 KRstMVGTPYWMAPE
Y453 ENPLRALYLIATNGT
K468 PELQNPEKLSPIFrD
R474 EKLSPIFRDFLNrCL
R474-m1 EKLSPIFrDFLNrCL
R479-m1 IFrDFLNrCLEMDVE
R488-m1 LEMDVEKrGSAKELL
S490 MDVEKrGSAKELLQH
K492 VEKrGSAKELLQHPF
K492 VEKrGSAKELLQHPF
S507 LKLAKPLSSLTPLIL
2607 : Phospho-PAK2 (Ser20) Antibody
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2605 : Phospho-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  rabbit

 
S2 ______MSDNGELED
S19-p PAPPVRMssTIFSTG
S20-p APPVRMssTIFSTGG
T21 PPVRMssTIFSTGGK
S24 RMssTIFSTGGKDPL
T25 MssTIFSTGGKDPLS
K28 TIFSTGGKDPLSANH
S32 TGGKDPLSANHSLKP
S36 DPLSANHSLKPLPSV
K38 LSANHSLKPLPSVPE
S42 HSLKPLPSVPEEKKP
K52 EEKKPRNKIIsIFSG
S55-p KPRNKIIsIFSGTEK
S58 NKIIsIFSGTEKGSK
G59 KIIsIFSGTEKGSKK
T60 IIsIFSGTEKGSKKK
K62 sIFSGTEKGSKKKEK
S64 FSGTEKGSKKKEKER
S75 EKERPEISPPSDFEH
S78 RPEISPPSDFEHTIH
K128 QAVLDVLKFYDSNTV
Y130 VLDVLKFYDSNTVKQ
S132 DVLKFYDSNTVKQKY
T134 LKFYDSNTVKQKYLs
K136 FYDSNTVKQKYLsFT
Y139 SNTVKQKYLsFTPPE
S141-p TVKQKYLsFTPPEKD
T143 KQKYLsFTPPEKDGF
D148 sFTPPEKDGFPSGAP
S152 PEKDGFPSGAPALNT
A154 KDGFPSGAPALNTKV
T159 SGAPALNTKVSETsA
S165-p NTKVSETsAVVTEED
T169 SETsAVVTEEDDDDE
S192-p PRPDHTKsIYTRsVI
Y194 PDHTKsIYTRsVIDP
T195 DHTKsIYTRsVIDPI
S197-p TKsIYTRsVIDPIPA
D212 PVGDSHVDSGAKSSD
S213 VGDSHVDSGAKSSDK
T228 QKKKTKMTDEEIMEK
K235 TDEEIMEKLRTIVSI
Y252 PKKKYTRYEKIGQGA
K254 KKYTRYEKIGQGASG
K278 LGQEVAIKQINLQKQ
K299 INEILVMKELKNPNI
K302 ILVMKELKNPNIVNF
K370 QVIHRDIKSDNVLLG
S381 VLLGMEGSVKLTDFG
T394 FGFCAQITPEQSKRS
K399 QITPEQSKRStMVGT
K399 QITPEQSKRStMVGT
S401 TPEQSKRStMVGTPY
T402-p PEQSKRStMVGTPYW
T406 KRStMVGTPYWMAPE
Y453 ENPLRALYLIATNGT
K468 PELQNPEKLSPIFRD
R474 EKLSPIFRDFLNRCL
R474 EKLSPIFRDFLNRCL
R479 IFRDFLNRCLEMDVE
R488 LEMDVEKRGSAKELL
S490 MDVEKRGSAKELLQH
K492 VEKRGSAKELLQHPF
K492 VEKRGSAKELLQHPF
S507 LKLAKPLSSLTPLIM
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