a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 18.104.22.168; Protein kinase, STE; STE group; STE20 family; PAKA subfamily
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: transferase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein tyrosine kinase activator activity; kinase activity; catalytic activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: regulation of apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; apoptosis; metabolic process; protein amino acid autophosphorylation; regulation of growth; cytokinesis; response to stress; mitotic cell cycle; protein amino acid phosphorylation; phosphorylation; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.