a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; EC 18.104.22.168; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily
Molecular Function: transferase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; Rac GTPase binding; nucleotide binding; protein tyrosine kinase activator activity; kinase activity; catalytic activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: cell migration; apoptosis; metabolic process; protein amino acid autophosphorylation; regulation of mitotic cell cycle; protein amino acid phosphorylation; Rho protein signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of MAPKKK cascade; regulation of growth; activation of protein kinase activity; stress-activated protein kinase signaling pathway; actin cytoskeleton organization and biogenesis; phosphorylation; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.