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TUBG1 (human)

Overview TUBG1 Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: centrosome; condensed nuclear chromosome; cytoplasm; polar microtubule; cytosol; gamma-tubulin complex Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton Biological Process: protein polymerization; mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; G2/M transition of mitotic cell cycle; meiotic spindle organization and biogenesis Reference #:  P23258 (UniProtKB) Alt. Names/Synonyms: Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1; TBG1; TUBG; TUBG1; TUBGCP1; Tubulin gamma-1 chain; tubulin, gamma 1; tubulin, gamma polypeptide Gene Symbols: TUBG1 Molecular weight: 51,170 Da Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBG1 1Z5V - A=1-449 (human) 1Z5W - A=1-449 (human) 3CB2 - A/B=1-451 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1Z5V 1Z5W 3CB2  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S131‑p intracellular localization: S131‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S32-p	LCAEHGIsPEGIVEE
2	1		K48-u	ATEGTDRkDVFFYQA
1	3		S80-p	VIHSILNsPYAKLYN
0	1		S129-p	IDREADGsDsLEGFV
1	1		S131-p	READGsDsLEGFVLC
0	1		K164-u	LNDRYPKkLVQTYSV
0	1		K193-u	YNSLLTLkRLTQNAD
0	5		S284-p	TTDQSVAsVRkTTVL
0	8		K287-u	QSVAsVRkTTVLDVM
0	8		K301-u	MRRLLQPkNVMVSTG
0	6		K335-u	VDPTQVHkSLQRIRE
2	7		K344-u	LQRIRERkLANFIPW
0	2		S364-p	QVALSRKsPYLPSAH
0	1		K397-a	RTCRQYDkLRkREAF
0	1		K400-a	RQYDkLRkREAFLEQ
0	2		K410-u	AFLEQFRkEDMFkDN
0	1		K415-u	FRkEDMFkDNFDEMD

	mouse
S32	LCAEHGISPEGIVEE
K48	ATEGTDRKDVFFYQA
S80	VIHSILNSSYAKLYN
S129	IDREADGSDSLEGFV
S131	READGSDSLEGFVLC
K164	LNDRYPKKLVQTYSV
K193	YNSLLTLKRLTQNAD
S284-p	TTDQSVAsVRKTTVL
K287	QSVAsVRKTTVLDVM
K301	MRRLLQPKNVMVSTG
K335	VDPTQVHKSLQRIRE
K344	LQRIRERKLANFIPW
S364	QVALSRKSPYLPSAH
K397	RTCRQFDKLRKREAF
K400	RQFDKLRKREAFMEQ
K410-u	AFMEQFRkEDIFKDN
K415	FRkEDIFKDNFDEMD

	rat
S32	LCAEHGISPEGIVEE
K48	ATEGTDRKDVFFYQA
S80	VIHSILNSSYAKLYN
S129	IDREADGSDSLEGFV
S131	READGSDSLEGFVLC
K164	LNDRYPKKLVQTYSV
K193	YNSLLTLKRLTQNAD
S284	TTDQSVASVRKTTVL
K287	QSVASVRKTTVLDVM
K301	MRRLLQPKNVMVSTG
K335	VDPTQVHKSLQRIRE
K344	LQRIRERKLANFIPW
S364	QVALSRKSPYLPSAH
K397	RTCRQFDKLRKREAF
K400	RQFDKLRKREAFMEQ
K410	AFMEQFRKEDIFKDN
K415	FRKEDIFKDNFDEMD

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