Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: centriole; centrosome; pericentriolar material; condensed nuclear chromosome; nonmotile primary cilium; cytoplasmic microtubule; apical part of cell; cytoplasm; leading edge; polar microtubule; cytosol; gamma-tubulin complex
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; GTP catabolic process; microtubule cytoskeleton organization and biogenesis; mitotic cell cycle; microtubule nucleation; G2/M transition of mitotic cell cycle; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.