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Protein Page:
TUBG1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TUBG1 Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: centriole; centrosome; pericentriolar material; condensed nuclear chromosome; nonmotile primary cilium; cytoplasmic microtubule; apical part of cell; leading edge; cytoplasm; polar microtubule; cytosol; gamma-tubulin complex
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; G2/M transition of mitotic cell cycle; microtubule nucleation; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis
Reference #:  P23258 (UniProtKB)
Alt. Names/Synonyms: Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1; TBG1; TUBG; TUBG1; TUBGCP1; Tubulin gamma-1 chain; tubulin, gamma 1; tubulin, gamma polypeptide
Gene Symbols: TUBG1
Molecular weight: 51,170 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TUBG1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S131‑p
intracellular localization: S131‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S32-p LCAEHGIsPEGIVEE
2 1 K48-u ATEGTDRkDVFFYQA
1 4 S80-p VIHSILNsPYAKLYN
0 1 S129-p IDREADGsDsLEGFV
1 1 S131-p READGsDsLEGFVLC
0 1 K164-u LNDRYPKkLVQTYSV
0 1 K193-u YNSLLTLkRLTQNAD
0 6 S284-p TTDQSVAsVRkTTVL
0 8 K287-u QSVAsVRkTTVLDVM
0 8 K301-u MRRLLQPkNVMVSTG
0 6 K335-u VDPTQVHkSLQRIRE
2 7 K344-u LQRIRERkLANFIPW
0 2 S364-p QVALSRKsPYLPSAH
0 2 K410-u AFLEQFRkEDMFkDN
0 1 K415-u FRkEDMFkDNFDEMD
  mouse

 
S32 LCAEHGISPEGIVEE
K48 ATEGTDRKDVFFYQA
S80 VIHSILNSSYAKLYN
S129 IDREADGSDSLEGFV
S131 READGSDSLEGFVLC
K164 LNDRYPKKLVQTYSV
K193 YNSLLTLKRLTQNAD
S284-p TTDQSVAsVRKTTVL
K287 QSVAsVRKTTVLDVM
K301 MRRLLQPKNVMVSTG
K335 VDPTQVHKSLQRIRE
K344 LQRIRERKLANFIPW
S364 QVALSRKSPYLPSAH
K410-u AFMEQFRkEDIFKDN
K415 FRkEDIFKDNFDEMD
  rat

 
S32 LCAEHGISPEGIVEE
K48 ATEGTDRKDVFFYQA
S80 VIHSILNSSYAKLYN
S129 IDREADGSDSLEGFV
S131 READGSDSLEGFVLC
K164 LNDRYPKKLVQTYSV
K193 YNSLLTLKRLTQNAD
S284 TTDQSVASVRKTTVL
K287 QSVASVRKTTVLDVM
K301 MRRLLQPKNVMVSTG
K335 VDPTQVHKSLQRIRE
K344 LQRIRERKLANFIPW
S364 QVALSRKSPYLPSAH
K410 AFMEQFRKEDIFKDN
K415 FRKEDIFKDNFDEMD
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