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Protein Page:
MRLC2V (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MRLC2V myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. Note: This description may include information from UniProtKB.
Protein type: Contractile protein
Cellular Component: cytoskeleton; contractile fiber; myofibril; cytoplasm; myosin complex; actin cytoskeleton
Molecular Function: actin monomer binding; metal ion binding; calcium ion binding
Biological Process: heart morphogenesis; muscle cell fate specification; heart contraction; heart development; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; cardiac muscle contraction; post-embryonic development
Reference #:  P51667 (UniProtKB)
Alt. Names/Synonyms: MLC-2; MLC-2v; Mlc2v; MLRV; Myl2; Mylpc; myosin light chain 2v; myosin light chain, phosphorylatable, cardiac ventricles; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light polypeptide 2, regulatory, cardiac, slow; OTTMUSP00000029571; OTTMUSP00000029619; ventricular myosin regulatory light chain
Gene Symbols: Myl2
Molecular weight: 18,864 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MRLC2V

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K8-ub MAPKKAKkRIEGGss
0 6 S14-p KkRIEGGssNVFsMF
5 19 S15-p kRIEGGssNVFsMFE
1 0 S15 kRIEGGsSNVFsMFE
2 3 S19-p GGssNVFsMFEQtQI
0 1 T24-p VFsMFEQtQIQEFKE
0 3 K46-ub NRDGFIDkNDLRDTF
0 1 T52 DkNDLRDTFAALGRV
0 2 K62-ub ALGRVNVkNEEIDEM
0 1 K91-ub TMFGEKLkGADPEET
0 1 T98 kGADPEETILNAFKV
0 40 K104 ETILNAFKVFDPEGk
0 2 K111 KVFDPEGKGsLkADy
0 1 K111-ub KVFDPEGkGsLkADy
0 2 S113-p FDPEGkGsLkADyVR
0 2 K115-ub PEGkGsLkADyVREM
1 130 Y118-p kGsLkADyVREMLTt
0 1 T124 DyVREMLTtQAERFS
0 1 T125-p yVREMLTtQAERFSk
0 1 K132-ub tQAERFSkEEIDQMF
0 2 Y152 DVTGNLDYKNLVHII
0 2 K153 VTGNLDYKNLVHIIT
0 53 K165-ac IITHGEEkD______
0 2 K165-ub IITHGEEkD______
  human

 
K8 MAPKKAKKRAGGANs
N14 KKRAGGANsNVFsMF
S15-p KRAGGANsNVFsMFE
S15 KRAGGANSNVFsMFE
S19-p GANsNVFsMFEQTQI
T24 VFsMFEQTQIQEFKE
K46 NRDGFIDKNDLRDTF
T52 DKNDLRDTFAALGRV
K62 ALGRVNVKNEEIDEM
K91 TMFGEKLKGADPEEt
T98-p KGADPEEtILNAFkV
K104-ac EtILNAFkVFDPEGk
K111-ac kVFDPEGkGVLKADy
K111 kVFDPEGKGVLKADy
V113 FDPEGkGVLKADyVR
K115 PEGkGVLKADyVREM
Y118-p kGVLKADyVREMLtT
T124-p DyVREMLtTQAERFS
T125 yVREMLtTQAERFSK
K132 TQAERFSKEEVDQMF
Y152-p DVTGNLDykNLVHII
K153-ac VTGNLDykNLVHIIT
K165-ac IITHGEEkD______
K165 IITHGEEKD______
  rat

 
K8 MSPKKAKKRLEGGss
S14-p KKRLEGGssNVFSMF
S15-p KRLEGGssNVFSMFE
S15-gl KRLEGGssNVFSMFE
S19 GGssNVFSMFEQTQI
T24 VFSMFEQTQIQEFKE
K46 NRDGFIDKNDLRDtF
T52-p DKNDLRDtFAALGRV
K62 ALGRVNVKNEEIDEM
K91 TMFGEKLKGADPEET
- under review  
K104 ETILNAFKVFDPEGK
K111 KVFDPEGKGsLKADy
K111 KVFDPEGKGsLKADy
S113-p FDPEGKGsLKADyVR
K115 PEGKGsLKADyVREM
Y118-p KGsLKADyVREMLTT
T124 DyVREMLTTQAERFS
T125 yVREMLTTQAERFSK
K132 TQAERFSKEEIDQMF
Y152 DVTGNLDYKNLVHII
K153 VTGNLDYKNLVHIIT
K165-ac IITHGEEkD______
K165 IITHGEEKD______
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