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Protein Page:
BDNF (human)

Overview
BDNF During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Cytokine; Cell development/differentiation
Cellular Component: synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; extracellular region
Molecular Function: growth factor activity; neurotrophin TRKB receptor binding
Biological Process: axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; learning and/or memory; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; regulation of metabolic process; negative regulation of neuron apoptosis; inner ear development; nervous system development; chronic inflammatory response; neuron recognition; regulation of short-term neuronal synaptic plasticity; negative regulation of striated muscle development; positive regulation of synaptogenesis; axon target recognition; response to hyperoxia; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; positive regulation of neuron differentiation; regulation of excitatory postsynaptic membrane potential
Reference #:  P23560 (UniProtKB)
Alt. Names/Synonyms: Abrineurin; BDNF; Brain-derived neurotrophic factor; MGC34632; neurotrophin
Gene Symbols: BDNF
Molecular weight: 27,818 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

BDNF

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, induced: T62‑p
transcription, induced: T62‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 T62-p GLTSLADtFEHVIEE
0 1 Y191-p TKCNPMGyTKEGCRG
  BDNF iso2  
T70 GLTSLADTFEHVIEE
Y199 TKCNPMGYTKEGCRG
  mouse

 
T64 TTTSLADTFEHVIEE
Y193 TKCNPMGYTKEGCRG
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