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Protein Page:
BDNF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BDNF During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell development/differentiation
Cellular Component: synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; extracellular region
Molecular Function: growth factor activity; neurotrophin TRKB receptor binding
Biological Process: axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; learning and/or memory; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; inner ear development; nervous system development; chronic inflammatory response; neuron recognition; regulation of short-term neuronal synaptic plasticity; negative regulation of striated muscle development; positive regulation of synaptogenesis; axon target recognition; response to hyperoxia; glutamate secretion; response to fluoxetine; response to hypoxia; nerve development; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation
Reference #:  P23560 (UniProtKB)
Alt. Names/Synonyms: Abrineurin; BDNF; Brain-derived neurotrophic factor; MGC34632; neurotrophin
Gene Symbols: BDNF
Molecular weight: 27,818 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

BDNF

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, induced: T62‑p
transcription, induced: T62‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T7 _MTILFLTMVISYFG
0 1 S11 LFLTMVISYFGCMKA
0 1 Y12 FLTMVISYFGCMKAA
0 1 K22 CMKAAPMKEANIRGQ
1 0 T62-p GLTSLADtFEHVIEE
0 1 K85-ac RPNEENNkDADLYTS
0 1 T155-p VTAADKKtAVDMSGG
0 1 Y191-p TKCNPMGyTKEGCRG
  BDNF iso2  
T15-p VMTILFLtMVIsyFG
S19-p LFLtMVIsyFGCMKA
Y20-p FLtMVIsyFGCMKAA
K30 CMKAAPMKEANIRGQ
T70 GLTSLADTFEHVIEE
K93 RPNEENNKDADLYTS
T163 VTAADKKTAVDMSGG
Y199 TKCNPMGYTKEGCRG
  mouse

 
T7 _MTILFLTMVISYFG
S11 LFLTMVISYFGCMKA
Y12 FLTMVISYFGCMKAA
K22-ac CMKAAPMkEVNVHGQ
T64 TTTSLADTFEHVIEE
K87 RPNEENHKDADLYTS
T157 VTAADKKTAVDMSGG
Y193 TKCNPMGYTKEGCRG
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