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KCNK18 (human)

Overview KCNK18 Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation. Interacts with calcineurin. Interacts with YWHAH, in a phosphorylation-dependent manner. Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Note: This description may include information from UniProtKB. Protein type: Channel, ligand-gated; Channel, potassium; Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: calcium-activated potassium channel activity; potassium channel activity; outward rectifier potassium channel activity Biological Process: synaptic transmission; potassium ion transport Reference #:  Q7Z418 (UniProtKB) Alt. Names/Synonyms: K2p18.1; KCNK18; KCNKI; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; TRESK; TRESK-2; TRESK2; TRIK; TWIK related spinal cord K+ channel; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel; TWIK-related spinal cord potassium channel Gene Symbols: KCNK18 Molecular weight: 43,671 Da Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states

Select Structure to View Below KCNK18

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y131-p	PVTRLGKyLCMLyAL
0	1		Y136-p	GKyLCMLyALFGIPL
0	1		Y163-p	ATILSTSyNRFRKFP
0	1		T173-p	FRKFPFFtRPLLsKW
0	1		S178-p	FFtRPLLsKWCPKsL
0	1		S184-p	LsKWCPKsLFKKKPD
0	1		S205-p	AVPQIIIsAEELPGP
0	1		T239-p	HALEKQNtLQLPPQA
4	1		S252-p	QAMERSNsCPELVLG
2	0		S262	ELVLGRLSYSIISNL
3	0		S264	VLGRLSYSIISNLDE
2	0		S267	RLSYSIISNLDEVGQ

	mouse
F142	PVTRLGKFLCMLYAL
Y147	GKFLCMLYALFGIPL
Y174	ATILSRAYSRFQALL
-	gap
-	gap
P194	IFKWRSLPLCRKQPD
D215	AIPQIVIDAGVDELL
K251	VAREKKNKLQPPTRP
S264-p	RPVERSNsCPELVLG
S274-p	ELVLGRLsCsILsNL
S276-p	VLGRLsCsILsNLDE
S279-p	RLsCsILsNLDEVGQ

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