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BRF2 (human)

Overview BRF2 General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Belongs to the TFIIB family. Note: This description may include information from UniProtKB. Cellular Component: nucleoplasm Molecular Function: zinc ion binding Biological Process: transcription from RNA polymerase III promoter; regulation of transcription, DNA-dependent; transcription initiation; gene expression Reference #:  Q9HAW0 (UniProtKB) Alt. Names/Synonyms: B-related factor 2; BRF-2; BRF2; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; BRFU; FLJ11052; hBRFU; hTFIIIB50; RNA polymerase III transcription initiation factor BRFU; TFIIIB50; transcription factor IIB- related factor, TFIIIB50; Transcription factor IIIB 50 kDa subunit Gene Symbols: BRF2 Molecular weight: 46,533 Da Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states

Select Structure to View Below BRF2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T140-p	LTMGAICtLLYADLD
0	1		S150-p	YADLDVFsSTYMQIV
0	1		K192-u	ASPSVPAkyVEDKEK
0	1		Y193-p	SPSVPAkyVEDKEKM
0	1		S202-p	EDKEKMLsRTMQLVE
0	1		T218-p	ANETWLVtGRHPLPV
0	2		Y260-p	LANVDLPyPASSRLQ
0	1		S306-p	DLLQHRQsLVRSAFR
0	1		K324-u	AEVETREkEPPGWGQ
0	10		S353-p	PQGKRPAsPALLLPP
0	9		S365-p	LPPCMLKsPKRICPV
0	3		S385-p	VTGDENIsDSEIEQY

	mouse
T140	LTMGTICTLLYADLD
S150	YADLDLFSGTYMQMV
K192	ASPSVPAKYVEDKDK
Y193	SPSVPAKYVEDKDKM
S202	EDKDKMLSRTLLLVE
T218	ADETWLVTGRHPLPI
Y260	LANVDLPYPAASRLQ
M306	DLLQHRHMLVRTAFR
-	gap
S354	PKRKRRASPTPLLPP
P366	LPPCMLKPPKRTHTL
S386-p	VTGDEDIsDSEIEQY

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