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TECPR1 (human)

Overview TECPR1 Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy; Ubiquitin conjugating system Cellular Component: lysosomal membrane; integral to membrane; cytoplasmic vesicle Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding Biological Process: autophagic vacuole fusion; autophagy Reference #:  Q7Z6L1 (UniProtKB) Alt. Names/Synonyms: DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; TCPR1; TECPR1; tectonin beta-propeller repeat containing 1; Tectonin beta-propeller repeat-containing protein 1 Gene Symbols: TECPR1 Molecular weight: 129,696 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TECPR1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K36-a	KDSQLEFkRVSATTQ
0	1		K36	KDSQLEFKRVSATTQ
0	16		Y140-p	TEKGGWTyAIDFPAT
0	1		T147	yAIDFPATYTKDKKW
0	1		S215-p	RLSVWAVsLQGKVWY
0	1		S301-p	MHISVGVsVVWAVTK
0	1		S386	RECDRSHSGSSSsLL
0	1		S388	CDRSHSGSSSsLLsA
0	1		S389	DRSHSGSSSsLLsAG
0	2		S391-p	SHSGSSSsLLsAGCF
0	1		S394-p	GSSSsLLsAGCFFGD
0	2		S409	EVRGSGESAPSDTDA
0	4		S412	GSGESAPSDTDASSE
0	4		S417	APSDTDASSEVERPG
0	1		-	gap
0	2		T441-p	LDDSKNAtGNsAsGL
0	1		-	gap
0	1		-	gap
0	2		S444-p	SKNAtGNsAsGLGAG
0	2		S446-p	NAtGNsAsGLGAGRT
0	1		P480	NTHPGPAPTPAELPW
0	1		T488-p	TPAELPWtNIDLKEA
0	1		K580	AQTAAWRKQIFQQLT
0	2		S645-p	GHDGVRDsILFIYYV
0	2		S746	DIFVSEPSPDLEAHE
0	1		S938-p	PIALRDVsIIPEsPG
0	1		S943-p	DVsIIPEsPGAEGsG
0	1		S949-p	EsPGAEGsGHSIALW
0	1		R1137	GWDHISVRANATRAP
0	1		Q1149	RAPRSSSQEQEPSAP

	mouse
K36-a	KDVQLEFkRVSAATQ
K36-u	KDVQLEFkRVSAATQ
Y140	TEKGGWTYAMDFPAt
T147-p	YAMDFPAtYTRDKKW
S215	RLSVWAVSLQGKVWY
S301	MHVSAGVSVVWAITK
S386-p	RESDRSHsGssSsLL
S388-p	SDRSHsGssSsLLSA
S389-p	DRSHsGssSsLLSAG
S391-p	SHsGssSsLLSAGCF
S394	GssSsLLSAGCFFGD
S410-p	VRGSGTEsAPsDTDA
S413-p	SGTEsAPsDTDAsLE
S418-p	APsDTDAsLEVERQG
S444-p	NSTNLKGsLSKGHET
-	gap
S452	LSKGHETSGNTDHST
T455	GHETSGNTDHSTENA
-	gap
-	gap
S485-p	DECRGPAsTPAELPW
T493	TPAELPWTNIDLKEP
K585-u	AQTAAWRkQIFQQLT
S650	GHDGARDSILFIYYV
S751-p	DIFVSEPsPDLEARE
S943	PITLSDVSIIPESAH
S948	DVSIIPESAHADGRG
R954	ESAHADGRGHNVALW
R1142-m2	GWDHISVrANATRVP
R1154-m2	RVPRNMSrDREARGP

	rat
K36	KDVQLEFKRVSAATQ
K36	KDVQLEFKRVSAATQ
Y140	TEKGGWTYAMDFPAT
T147	YAMDFPATYTRDKKW
S215	RLSVWAVSLQGKVWY
S301	MHVSAGVSVVWAITK
S386	RESDRSHSGSSSSLL
S388	SDRSHSGSSSSLLSA
S389	DRSHSGSSSSLLSAG
S391	SHSGSSSSLLSAGCF
S394	GSSSSLLSAGCFFGE
S410	VRGSGTESAPSDTDA
S413	SGTESAPSDTDASSE
S418	APSDTDASSEVERQG
S444	NSRNLKGSSSKGHES
-	gap
T452-p	SSKGHEStRNtEDPM
T455-p	GHEStRNtEDPMENA
-	gap
-	gap
P485	DECHGPAPTPAELPW
T493	TPAELPWTNIDLKEP
K585	AQTAAWRKQIFQQLT
S650	GHDGARDSILFIYYV
S751	DIFVSEPSPDLEAHE
S943	PIALSDVSIIPESAD
S948	DVSIIPESADANGRG
R954	ESADANGRGHNIALW
R1142	GWDHISVRANATRAP
R1154	RAPRNMSRDQEAHGP

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