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Protein Page:
TECPR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TECPR1 Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Autophagy
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: lysosomal membrane; integral to membrane; cytoplasmic vesicle
Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding
Biological Process: autophagic vacuole fusion; autophagy
Reference #:  Q7Z6L1 (UniProtKB)
Alt. Names/Synonyms: DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; TCPR1; TECPR1; tectonin beta-propeller repeat containing 1; Tectonin beta-propeller repeat-containing protein 1
Gene Symbols: TECPR1
Molecular weight: 129,696 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TECPR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K36 KDSQLEFKRVSATTQ
0 1 K36 KDSQLEFKRVSATTQ
0 15 Y140-p TEKGGWTyAIDFPAT
0 1 T147 yAIDFPATYTKDKKW
0 1 S215-p RLSVWAVsLQGKVWY
0 1 S301-p MHISVGVsVVWAVTK
0 1 S386 RECDRSHSGSSSsLL
0 1 S388 CDRSHSGSSSsLLsA
0 1 S389 DRSHSGSSSsLLsAG
0 2 S391-p SHSGSSSsLLsAGCF
0 1 S394-p GSSSsLLsAGCFFGD
0 2 S409 EVRGSGESAPSDTDA
0 4 S412 GSGESAPSDTDASSE
0 5 S417 APSDTDASSEVERPG
0 1 - gap
0 2 T441-p LDDSKNAtGNsAsGL
0 1 - gap
0 1 - gap
0 2 S444-p SKNAtGNsAsGLGAG
0 2 S446-p NAtGNsAsGLGAGRT
0 1 P480 NTHPGPAPTPAELPW
0 1 T488-p TPAELPWtNIDLKEA
0 1 K580 AQTAAWRKQIFQQLT
0 2 S645-p GHDGVRDsILFIYYV
0 2 S746 DIFVSEPSPDLEAHE
0 1 S938-p PIALRDVsIIPEsPG
0 1 S943-p DVsIIPEsPGAEGsG
0 1 S949-p EsPGAEGsGHSIALW
0 1 R1137 GWDHISVRANATRAP
0 1 Q1149 RAPRSSSQEQEPSAP
  mouse

 
K36-ac KDVQLEFkRVSAATQ
K36-ub KDVQLEFkRVSAATQ
Y140 TEKGGWTYAMDFPAt
T147-p YAMDFPAtYTRDKKW
S215 RLSVWAVSLQGKVWY
S301 MHVSAGVSVVWAITK
S386-p RESDRSHsGssSsLL
S388-p SDRSHsGssSsLLSA
S389-p DRSHsGssSsLLSAG
S391-p SHsGssSsLLSAGCF
S394 GssSsLLSAGCFFGD
S410-p VRGSGTEsAPsDTDA
S413-p SGTEsAPsDTDAsLE
S418-p APsDTDAsLEVERQG
S444-p NSTNLKGsLSKGHET
- gap
S452 LSKGHETSGNTDHST
T455 GHETSGNTDHSTENA
- gap
- gap
S485-p DECRGPAsTPAELPW
T493 TPAELPWTNIDLKEP
K585-ub AQTAAWRkQIFQQLT
S650 GHDGARDSILFIYYV
S751-p DIFVSEPsPDLEARE
S943 PITLSDVSIIPESAH
S948 DVSIIPESAHADGRG
R954 ESAHADGRGHNVALW
R1142-m2 GWDHISVrANATRVP
R1154-m2 RVPRNMSrDREARGP
  rat

 
K36 KDVQLEFKRVSAATQ
K36 KDVQLEFKRVSAATQ
Y140 TEKGGWTYAMDFPAT
T147 YAMDFPATYTRDKKW
S215 RLSVWAVSLQGKVWY
S301 MHVSAGVSVVWAITK
S386 RESDRSHSGSSSSLL
S388 SDRSHSGSSSSLLSA
S389 DRSHSGSSSSLLSAG
S391 SHSGSSSSLLSAGCF
S394 GSSSSLLSAGCFFGE
S410 VRGSGTESAPSDTDA
S413 SGTESAPSDTDASSE
S418 APSDTDASSEVERQG
S444 NSRNLKGSSSKGHES
- gap
T452-p SSKGHEStRNtEDPM
T455-p GHEStRNtEDPMENA
- gap
- gap
P485 DECHGPAPTPAELPW
T493 TPAELPWTNIDLKEP
K585 AQTAAWRKQIFQQLT
S650 GHDGARDSILFIYYV
S751 DIFVSEPSPDLEAHE
S943 PIALSDVSIIPESAD
S948 DVSIIPESADANGRG
R954 ESADANGRGHNIALW
R1142 GWDHISVRANATRAP
R1154 RAPRNMSRDQEAHGP
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