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Protein Page:
SEC23A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEC23A Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A. Belongs to the SEC23/SEC24 family. SEC23 subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; endoplasmic reticulum; perinuclear region of cytoplasm; smooth endoplasmic reticulum membrane; cytosol
Molecular Function: protein binding; zinc ion binding
Biological Process: vesicle-mediated transport; COPII coating of Golgi vesicle; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  Q15436 (UniProtKB)
Alt. Names/Synonyms: CLSD; MGC26267; Protein transport protein Sec23A; SC23A; Sec23 homolog A (S. cerevisiae); SEC23-related protein A; SEC23A
Gene Symbols: SEC23A
Molecular weight: 86,161 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC23A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T43-p VPVAALFtPLkERPD
0 2 K46-ub AALFtPLkERPDLPP
0 1 S62-p QYEPVLCsRTTCRAV
0 1 S150-p DLQALKEsMQMSLSL
0 2 K198-ub GTKDLSAkQLQEMLG
0 2 K208-ub QEMLGLSkVPLTQAT
0 2 K307-ub MVVGDELktPIRSWH
0 1 T308-p VVGDELktPIRSWHD
0 1 K318 RSWHDIDKDNAKYVK
0 1 K318 RSWHDIDKDNAKYVK
0 1 T328 AKYVKKGTKHFEALA
0 1 Y348 TGHVIDIYACALDQT
0 1 K392 TFQRVFTKDMHGQFK
0 1 T405-p FKMGFGGtLEIKTSR
0 1 K556 QLIRLCQKFGEYHkD
0 1 K562 QKFGEYHKDDPSSFR
0 1 K562-ub QKFGEYHkDDPSSFR
0 2 S588-p MFHLRRSsFLQVFNN
0 3 K669-ub ETIAQWRkSGYQDMP
0 2 Y678-p GYQDMPEyENFRHLL
0 1 S713-p IDTEHGGsQARFLLS
  mouse

 
T43 VPVAALFTPLkERPD
K46-ub AALFTPLkERPDLPP
S62 QYEPVLCSRTTCRAV
S150 DLQALKESMQMSLSL
K198-ub GTKDLSAkQLQEMLG
K208-ub QEMLGLSkVPVTQAT
K307-ub MVVGDELkTPIRSWH
T308 VVGDELkTPIRSWHD
K318-ac RSWHDIEkDNAKYVK
K318-ub RSWHDIEkDNAKYVK
T328 AKYVKKGTKHFEALA
Y348 TGHVIDIYACALDQT
K392-ub TFQRVFTkDIHGQFK
T405 FKMGFGGTLEIKTSR
K556-ub QLIRLCQkFGEYHkD
K562-ac QkFGEYHkDDPNSFR
K562 QkFGEYHKDDPNSFR
P588 MFHLRRSPFLQVFNN
K669-ub ETIAQWRkSGYQDMP
Y678 GYQDMPEYENFRHLL
S713 IDTEHGGSQARFLLS
  rat

 
T43 VPVAALFTPLKERPD
K46 AALFTPLKERPDLPP
S62 QYEPVLCSRTTCRAV
S150 DLQALKESMQMSLSL
K198 GTKDLSAKQLQEMLG
K208 QEMLGLSKVPVTQAT
K307 MVVGDELKTPIRSWH
T308 VVGDELKTPIRSWHD
K318 RSWHDIEKDNAKYVK
K318 RSWHDIEKDNAKYVK
T328-p AKYVKKGtKHFEALA
Y348-p TGHVIDIyACALDQT
K392 TFQRVFTKDIHGQFK
T405 FKMGFGGTLEIKTSR
K556 QLIRLCQKFGEYHKD
K562 QKFGEYHKDDPNSFR
K562 QKFGEYHKDDPNSFR
P588 MFHLRRSPFLQVFNN
K669 ETIAQWRKSGYQDMP
Y678 GYQDMPEYENFRHLL
S713 IDTEHGGSQARFLLS
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