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SEC23A (human)

Overview SEC23A Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A. Belongs to the SEC23/SEC24 family. SEC23 subfamily. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; endoplasmic reticulum; perinuclear region of cytoplasm; smooth endoplasmic reticulum membrane; cytosol Molecular Function: protein binding; zinc ion binding Biological Process: vesicle-mediated transport; COPII coating of Golgi vesicle; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; membrane organization and biogenesis Reference #:  Q15436 (UniProtKB) Alt. Names/Synonyms: CLSD; MGC26267; Protein transport protein Sec23A; SC23A; Sec23 homolog A (S. cerevisiae); SEC23-related protein A; SEC23A Gene Symbols: SEC23A Molecular weight: 86,161 Da Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SEC23A 2YRC - A=57-108 (human) 2YRD - A=57-108 (human) 3EFO - A=1-765 (human) 3EG9 - A=1-764 (human) 3EGD - A=1-764 (human) 3EGX - A=1-764 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX  |  Phospho3D  |  DISEASE 607812 610511  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T43-p	VPVAALFtPLkERPD
0	2		K46-u	AALFtPLkERPDLPP
0	1		S62-p	QYEPVLCsRTTCRAV
0	1		S150-p	DLQALKEsMQMSLSL
0	2		K198-u	GTKDLSAkQLQEMLG
0	2		K208-u	QEMLGLSkVPLTQAT
0	2		K307-u	MVVGDELktPIRSWH
0	1		T308-p	VVGDELktPIRSWHD
0	1		K318	RSWHDIDKDNAKYVK
0	1		T328	AKYVKKGTKHFEALA
0	1		Y348	TGHVIDIYACALDQT
0	1		K392	TFQRVFTKDMHGQFK
0	1		T405-p	FKMGFGGtLEIKTSR
0	1		K556	QLIRLCQKFGEYHkD
0	1		K562-u	QKFGEYHkDDPSSFR
0	2		S588-p	MFHLRRSsFLQVFNN
0	3		K669-u	ETIAQWRkSGYQDMP
0	2		Y678-p	GYQDMPEyENFRHLL

	mouse
T43	VPVAALFTPLkERPD
K46-u	AALFTPLkERPDLPP
S62	QYEPVLCSRTTCRAV
S150	DLQALKESMQMSLSL
K198-u	GTKDLSAkQLQEMLG
K208-u	QEMLGLSkVPVTQAT
K307-u	MVVGDELkTPIRSWH
T308	VVGDELkTPIRSWHD
K318-u	RSWHDIEkDNAKYVK
T328	AKYVKKGTKHFEALA
Y348	TGHVIDIYACALDQT
K392-u	TFQRVFTkDIHGQFK
T405	FKMGFGGTLEIKTSR
K556-u	QLIRLCQkFGEYHKD
K562	QkFGEYHKDDPNSFR
P588	MFHLRRSPFLQVFNN
K669-u	ETIAQWRkSGYQDMP
Y678	GYQDMPEYENFRHLL

	rat
T43	VPVAALFTPLKERPD
K46	AALFTPLKERPDLPP
S62	QYEPVLCSRTTCRAV
S150	DLQALKESMQMSLSL
K198	GTKDLSAKQLQEMLG
K208	QEMLGLSKVPVTQAT
K307	MVVGDELKTPIRSWH
T308	VVGDELKTPIRSWHD
K318	RSWHDIEKDNAKYVK
T328-p	AKYVKKGtKHFEALA
Y348-p	TGHVIDIyACALDQT
K392	TFQRVFTKDIHGQFK
T405	FKMGFGGTLEIKTSR
K556	QLIRLCQKFGEYHKD
K562	QKFGEYHKDDPNSFR
P588	MFHLRRSPFLQVFNN
K669	ETIAQWRKSGYQDMP
Y678	GYQDMPEYENFRHLL

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