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PIGH (human)

Overview PIGH Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGH family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, anchored; EC 2.4.1.198; Transferase; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Endoplasmic reticulum Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; mitochondrion; endoplasmic reticulum; cytoplasm; nucleolus; nucleus Molecular Function: phosphatidylinositol N-acetylglucosaminyltransferase activity; catalytic activity Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; protein modification process; C-terminal protein lipidation; post-translational protein modification Reference #:  Q14442 (UniProtKB) Alt. Names/Synonyms: GPI-H; phosphatidylinositol glycan anchor biosynthesis, class H; phosphatidylinositol glycan, class H; Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Phosphatidylinositol-glycan biosynthesis class H protein; phosphatidylinositol-glycan biosynthesis, class H protein; PIG-H; PIGH Gene Symbols: PIGH Molecular weight: 21,081 Da Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states

Select Structure to View Below PIGH

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6-p	__MEDERsFSDICGG
0	1		T42-p	RLSLRSLtAVtCTVW
0	1		T45-p	LRSLtAVtCTVWLAA
0	1		S110	SYASGKESTTFIEMG
0	1		T111	YASGKESTTFIEMGK
0	1		T112	ASGKESTTFIEMGKV

	mouse
S6	__MEDEKSFSDICGG
T42	RLSLCSLTAVTCAVW
T45	LCSLTAVTCAVWLAA
S110	SYASGKESTTFIEMD
T111	YASGKESTTFIEMDK
T112	ASGKESTTFIEMDKV

	rat
S6	__MEDEKSFSDICGG
T42	RLSLWSLTAVTCTVW
T45	LWSLTAVTCTVWLAA
S110-p	SYASGKEsttFIEMN
T111-p	YASGKEsttFIEMNK
T112-p	ASGKEsttFIEMNKV

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