Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Secreted; EC 3.4.24.-; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; calcium ion binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.