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Protein Page:
MMP20 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MMP20 Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Protease; EC 3.4.24.-
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis
Reference #:  O60882 (UniProtKB)
Alt. Names/Synonyms: AI2A2; Enamel metalloproteinase; Enamelysin; matrix metallopeptidase 20; matrix metalloproteinase 20 (enamelysin); Matrix metalloproteinase-20; MMP-20; MMP20
Gene Symbols: MMP20
Molecular weight: 54,387 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  GPCR Signaling to MAPKs
Select Structure to View Below

MMP20

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y48-p AQAYLDKyyTNKEGH
0 1 Y49-p QAYLDKyyTNKEGHQ
0 2 K128-ac TLTYRISkYTPSMSS
0 1 V136 YTPSMSSVEVDkAVE
0 2 K140-ac MSSVEVDkAVEMALQ
0 1 Y415-p FFVGDEYysyDERKR
0 1 S416-p FVGDEYysyDERKRK
0 1 Y417-p VGDEYysyDERKRKM
0 1 T461-p YFFSGPKtyKyDtEK
0 1 Y462-p FFSGPKtyKyDtEKE
0 1 Y464-p SGPKtyKyDtEKEDV
0 1 T466-p PKtyKyDtEKEDVVS
  mouse

 
Y47 AQAYLDKYYTKKGGP
Y48 QAYLDKYYTKKGGPQ
K127 ILTYRISKYTPSMSP
T135 YTPSMSPTEVDKAIQ
K139 MSPTEVDKAIQMALH
Y414 FFVGEEYYSYDERKK
S415 FVGEEYYSYDERKKK
Y416 VGEEYYSYDERKKKM
T460 YFFSGRKTFKYDTEK
F461 FFSGRKTFKYDTEKE
Y463 SGRKTFKYDTEKEDV
T465 RKTFKYDTEKEDVVS
  rat

 
Y47 AQAYLDKYYTKKGGP
Y48 QAYLDKYYTKKGGPQ
K127 ILTYRVSKYTPSMSP
T135-p YTPSMSPtEVDKAVH
K139 MSPtEVDKAVHMALH
Y414 FFVGEEYYSYDERKK
S415 FVGEEYYSYDERKKK
Y416 VGEEYYSYDERKKKM
T460 YFFSGPKTFKYDTEK
F461 FFSGPKTFKYDTEKE
Y463 SGPKTFKYDTEKEDV
T465 PKTFKYDTEKEDVVS
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