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APR3 (human)

Overview APR3 May play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines. Weakly expressed in hematopoietic cell lines. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: perinuclear region of cytoplasm; integral to membrane; plasma membrane; nuclear envelope Molecular Function: protein binding Biological Process: positive regulation of osteoblast differentiation; regulation of gene expression; negative regulation of osteoblast proliferation; positive regulation of bone mineralization; cell differentiation Reference #:  Q6UW56 (UniProtKB) Alt. Names/Synonyms: apoptosis related protein 3; apoptosis related protein APR-3; Apoptosis-related protein 3; APR--3; APR-3; APR3; C2orf28; chromosome 2 open reading frame 28; HSPC013; p18; PRO240 Gene Symbols: ATRAID Molecular weight: 24,747 Da Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below APR3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K53-u	SKVAFYCkTTRELML
0	1		E57	FYCkTTRELMLHARC
0	1		H93	GPNFHQAHTTVIIDL
0	1		T94	PNFHQAHTTVIIDLQ

	mouse
E48	SRVAAYCEDTSkLMQ
K52-u	AYCEDTSkLMQARCC
Y87	GPNFLQAYTAIIIDL
T88	PNFLQAYTAIIIDLQ

	rat
E94	SRVAAYCEDTSKLMQ
K98	AYCEDTSKLMQARCC
Y131-p	DPNLFPAytAVIIDL
T132-p	PNLFPAytAVIIDLQ

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