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Protein Page:
APR3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APR3 May play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines. Weakly expressed in hematopoietic cell lines. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: perinuclear region of cytoplasm; integral to membrane; plasma membrane; nuclear envelope
Molecular Function: protein binding
Biological Process: positive regulation of osteoblast differentiation; regulation of gene expression; negative regulation of osteoblast proliferation; cell differentiation; positive regulation of bone mineralization
Reference #:  Q6UW56 (UniProtKB)
Alt. Names/Synonyms: apoptosis related protein 3; apoptosis related protein APR-3; Apoptosis-related protein 3; APR--3; APR-3; APR3; C2orf28; chromosome 2 open reading frame 28; HSPC013; p18; PRO240
Gene Symbols: ATRAID
Molecular weight: 24,747 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APR3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K53-ub SKVAFYCkTTRELML
0 1 E57 FYCkTTRELMLHARC
0 1 H93 GPNFHQAHTTVIIDL
0 1 T94 PNFHQAHTTVIIDLQ
  mouse

 
E48 SRVAAYCEDTSkLMQ
K52-ub AYCEDTSkLMQARCC
Y87 GPNFLQAYTAIIIDL
T88 PNFLQAYTAIIIDLQ
  rat

 
E94 SRVAAYCEDTSKLMQ
K98 AYCEDTSKLMQARCC
Y131-p DPNLFPAytAVIIDL
T132-p PNLFPAytAVIIDLQ
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