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Protein Page:
MGAT4C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MGAT4C Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). Belongs to the glycosyltransferase 54 family. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.4.1.145; Membrane protein, integral
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; metal ion binding
Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  Q9UBM8 (UniProtKB)
Alt. Names/Synonyms: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; GlcNAc-T IVc; GnT-IVc; GNTIVH; hGnT-IV-H; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); MGAT4C; MGT4C; N-acetylglucosaminyltransferase IV homolog; N-acetylglucosaminyltransferase IVc; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog
Gene Symbols: MGAT4C
Molecular weight: 56,061 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Select Structure to View Below

MGAT4C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S77 VHTFKDLSNFsGAIN
0 2 S80-p FKDLSNFsGAINVTy
0 1 A82 DLSNFsGAINVTyRy
0 1 Y87-p sGAINVTyRyLAAtP
0 4 Y89-p AINVTyRyLAAtPLQ
0 3 T93-p TyRyLAAtPLQRKRY
0 1 K98 AAtPLQRKRYLTIGL
0 1 Y178-p VIHAPEEyyPILDGL
0 1 Y179-p IHAPEEyyPILDGLK
0 1 T396-p IKKIKVNtGtEDRQN
0 1 T398-p KIKVNtGtEDRQNDI
  MGAT4C iso4  
S77 VHTFKDLSNFSGAIN
S80 FKDLSNFSGAINVTY
A82 DLSNFSGAINVTYRY
Y87 SGAINVTYRYLAATP
Y89 AINVTYRYLAATPLQ
T93 TYRYLAATPLQRkPH
K98-m1 AATPLQRkPHGLLFI
- gap
- gap
- gap
- gap
  mouse

 
S77 VHTFKDLSNFSGTIN
S80 FKDLSNFSGTINVTY
T82 DLSNFSGTINVTYRY
Y87 SGTINVTYRYLAATP
Y89 TINVTYRYLAATPLQ
T93 TYRYLAATPLQRKRY
K98 AATPLQRKRYLTIGL
Y178 VIHAPEEYYPVLDGL
Y179 IHAPEEYYPVLDGLK
T396 IKKIKVNTGTEDRQN
T398 KIKVNTGTEDRQNDI
  rat

 
S92-p VHTFKDLsNFsGtIN
S95-p FKDLsNFsGtINVTY
T97-p DLsNFsGtINVTYRY
Y102 sGtINVTYRYLAAtP
Y104 tINVTYRYLAAtPLQ
T108-p TYRYLAAtPLQRKRY
K113 AAtPLQRKRYLTIGL
Y193 VIHAPEEYYPVLDGL
Y194 IHAPEEYYPVLDGLK
T411 IKKIKVNTGTEDRQN
T413 KIKVNTGTEDRQNDI
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