Home

MGAT4C (human)

Overview MGAT4C Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). Belongs to the glycosyltransferase 54 family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; EC 2.4.1.145; Transferase Cellular Component: Golgi membrane; integral to membrane Molecular Function: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; metal ion binding Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification Reference #:  Q9UBM8 (UniProtKB) Alt. Names/Synonyms: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; GlcNAc-T IVc; GnT-IVc; GNTIVH; hGnT-IV-H; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); MGAT4C; MGT4C; N-acetylglucosaminyltransferase IV homolog; N-acetylglucosaminyltransferase IVc; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog Gene Symbols: MGAT4C Molecular weight: 56,061 Da Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states

Select Structure to View Below MGAT4C

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S77	VHTFKDLSNFsGAIN
0	2		S80-p	FKDLSNFsGAINVTy
0	1		A82	DLSNFsGAINVTyRy
0	1		Y87-p	sGAINVTyRyLAAtP
0	4		Y89-p	AINVTyRyLAAtPLQ
0	3		T93-p	TyRyLAAtPLQRKRY
0	1		Y178-p	VIHAPEEyyPILDGL
0	1		Y179-p	IHAPEEyyPILDGLK
0	1		T396-p	IKKIKVNtGtEDRQN
0	1		T398-p	KIKVNtGtEDRQNDI

	mouse
S77	VHTFKDLSNFSGTIN
S80	FKDLSNFSGTINVTY
T82	DLSNFSGTINVTYRY
Y87	SGTINVTYRYLAATP
Y89	TINVTYRYLAATPLQ
T93	TYRYLAATPLQRKRY
Y178	VIHAPEEYYPVLDGL
Y179	IHAPEEYYPVLDGLK
T396	IKKIKVNTGTEDRQN
T398	KIKVNTGTEDRQNDI

	rat
S92-p	VHTFKDLsNFsGtIN
S95-p	FKDLsNFsGtINVTY
T97-p	DLsNFsGtINVTYRY
Y102	sGtINVTYRYLAAtP
Y104	tINVTYRYLAAtPLQ
T108-p	TYRYLAAtPLQRKRY
Y193	VIHAPEEYYPVLDGL
Y194	IHAPEEYYPVLDGLK
T411	IKKIKVNTGTEDRQN
T413	KIKVNTGTEDRQNDI

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.