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Protein Page:
JMJD3 (human)

Overview
JMJD3 Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase
Cellular Component: nucleoplasm
Molecular Function: protein binding; dioxygenase activity; sequence-specific DNA binding; metal ion binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Reference #:  O15054 (UniProtKB)
Alt. Names/Synonyms: JmjC domain-containing protein 3; JMJD3; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; KDM6B; KIAA0346; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B
Gene Symbols: KDM6B
Molecular weight: 176,632 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S224-p PSGEEGLsPGGKRRR
0 1 T397 PPGLPGTTTSsSSSS
0 2 S400-p LPGTTTSsSSSSSSN
0 1 S403 TTTSsSSSSSSNTGL
0 2 S627-p GSFRRPEsPRPRVSF
0 4 T637-p PRVSFPKtPEVGPGP
0 2 S1034-p EIQGREKsRPDLGGA
0 1 T1524-p VSWNVARtVKIsDPD
0 1 S1528-p VARtVKIsDPDLFKM
0 2 Y1563-p RAGKKIAyQGRVKDE
  mouse

 
S224-p PSGEEGLsPGGKRRR
S399 PPGLPGTSSSSSSSS
S402 LPGTSSSSSSSSSSN
S405 TSSSSSSSSSSNNTG
S629 GSFRRSESPRPRVSF
T639 PRVSFPKTPEVGQGP
A1032 EIQGREKARPDVGGV
T1522 VSWNVARTVKISDPD
S1526 VARTVKISDPDLFKM
Y1561 RAGKKIAYQGRVKDE
  rat

 
S16 PSGEEGLSPGGKRRR
S123-p PPGLPGTsSSsSSsN
S126-p LPGTsSSsSSsNNTG
S129-p TsSSsSSsNNTGLRG
S353 GSFRRSESPRPRVSF
T363 PRVSFPKTPEVGQGP
A752 EIQGREKARPDVGGA
T1242 VSWNVARTVKISDPD
S1246 VARTVKISDPDLFKM
Y1281 RAGKKIAYQGRVKDE
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