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JMJD3 (human)

Overview JMJD3 Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 1.14.11.-; Oxidoreductase Cellular Component: nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; sequence-specific DNA binding; metal ion binding Biological Process: histone demethylation; negative regulation of transcription from RNA polymerase II promoter; inflammatory response Reference #:  O15054 (UniProtKB) Alt. Names/Synonyms: JmjC domain-containing protein 3; JMJD3; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; KDM6B; KIAA0346; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B Gene Symbols: KDM6B Molecular weight: 176,632 Da Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JMJD3 2XUE - A/B=1138-1640 (human) 2XXZ - A/B=1173-1502 (human) 4ASK - A/B=1141-1643 (human) 4EYU - A/B=1321-1641 (mouse) 4EZ4 - A/B=1321-1641 (mouse) 4EZH - A/B=1321-1641 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S48-p	WLPGGRCsAsIGQPP
0	1		S50-p	PGGRCsAsIGQPPLP
0	1		S218-p	PAALSGPsGEEGLSP
0	1		T380-p	SVSPAATtACVPYAP
0	1		T397	PPGLPGTTTSsSSSS
0	2		S400-p	LPGTTTSsSSSSSsN
0	1		S403	TTTSsSSSSSsNTGL
0	1		S406-p	SsSSSSSsNTGLRGV
0	2		S627-p	GSFRRPEsPRPRVSF
0	3		T637-p	PRVSFPKtPEVGPGP
0	1		K689-a	FEEPAEFkILPDGLA
0	1		K700-a	DGLANIMkMLDESIR
0	1		T894-p	EPVPGPMtPTQPPPP
0	1		K977	GSCKRRQKEHQKEHR
0	1		S1025-p	LGNLDLQsEEIQGRE
0	2		S1034-p	EIQGREKsRPDLGGA
0	1		S1042-p	RPDLGGAsKAKPPTA
0	1		K1154-u	RNAKVKGkFRESYLS
0	1		T1524-p	VSWNVARtVKIsDPD
0	1		S1528-p	VARtVKIsDPDLFKM
0	2		Y1563-p	RAGKKIAyQGRVKDE

	mouse
S48	WLPGGRCSASVGQPP
S50	PGGRCSASVGQPPLS
S218	PAALSGPSGEEGLSP
T382	SVSPAASTACVPYAP
S399	PPGLPGTSSSSSSSS
S402	LPGTSSSSSSSSSSN
S405	TSSSSSSSSSSNNTG
S408	SSSSSSSSNNTGLRG
S629	GSFRRSESPRPRVSF
T639	PRVSFPKTPEVGQGP
K691	FEEPAEFKILPDGLA
K702	DGLANIMKMLDESIR
T896	EPAPGPVTPAQLPPP
K975-a	AAGPGSGkRRQKEHR
S1023	LGNLDLQSEEIQGRE
A1032	EIQGREKARPDVGGV
S1040	RPDVGGVSKVKTPTA
K1152	KNAKVKGKFRESYLS
T1522	VSWNVARTVKISDPD
S1526	VARTVKISDPDLFKM
Y1561	RAGKKIAYQGRVKDE

	rat
-	gap
-	gap
S10	PAALSGPSGEEGLSP
T106	SVSPAASTACVPYAP
S123-p	PPGLPGTsSSsSSsN
S126-p	LPGTsSSsSSsNNTG
S129-p	TsSSsSSsNNTGLRG
-	gap
S353	GSFRRSESPRPRVSF
T363	PRVSFPKTPEVGQGP
K415	FEEPAEFKILPDGLA
K426	DGLANIMKMLDESIR
T613	EPAPGPVTPAQLPPP
K695	AAGPGSGKRRQKEHR
S743	LGNLDLQSEEIQGRE
A752	EIQGREKARPDVGGA
S760	RPDVGGASKVKTPTT
K872	KNAKVKGKFRESYLS
T1242	VSWNVARTVKISDPD
S1246	VARTVKISDPDLFKM
Y1281	RAGKKIAYQGRVKDE

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