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Protein Page:
JMJD3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JMJD3 Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; dioxygenase activity; sequence-specific DNA binding; metal ion binding
Biological Process: endothelial cell differentiation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cardiac muscle cell differentiation
Reference #:  O15054 (UniProtKB)
Alt. Names/Synonyms: JmjC domain-containing protein 3; JMJD3; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; KDM6B; KIAA0346; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B
Gene Symbols: KDM6B
Molecular weight: 176,632 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S48-p WLPGGRCsAsIGQPP
0 1 S50-p PGGRCsAsIGQPPLP
0 1 S218-p PAALSGPsGEEGLsP
0 2 S224-p PsGEEGLsPGGKRRR
0 1 T380-p SVSPAATtACVPYAP
0 1 T397 PPGLPGTTTSsSSSS
0 2 S400-p LPGTTTSsSSSSSsN
0 1 S403 TTTSsSSSSSsNTGL
0 1 S406-p SsSSSSSsNTGLRGV
0 2 S627-p GSFRRPEsPRPRVSF
0 3 T637-p PRVSFPKtPEVGPGP
0 1 K689-ac FEEPAEFkILPDGLA
0 1 K700-ac DGLANIMkMLDESIR
0 1 T894-p EPVPGPMtPTQPPPP
0 1 K977 GSCKRRQKEHQKEHR
0 1 S1025-p LGNLDLQsEEIQGRE
0 2 S1034-p EIQGREKsRPDLGGA
0 1 S1042-p RPDLGGAsKAKPPTA
0 1 S1085-p APGPPGVsRADMLKL
0 1 K1154-ub RNAKVKGkFRESYLS
0 1 T1524-p VSWNVARtVKIsDPD
0 1 S1528-p VARtVKIsDPDLFKM
0 2 Y1563-p RAGKKIAyQGRVKDE
  mouse

 
S48 WLPGGRCSASVGQPP
S50 PGGRCSASVGQPPLS
S218 PAALSGPSGEEGLsP
S224-p PSGEEGLsPGGKRRR
T382 SVSPAASTACVPYAP
S399 PPGLPGTSSSSSSSS
S402 LPGTSSSSSSSSSSN
S405 TSSSSSSSSSSNNTG
S408 SSSSSSSSNNTGLRG
S629 GSFRRSESPRPRVSF
T639 PRVSFPKTPEVGQGP
K691 FEEPAEFKILPDGLA
K702 DGLANIMKMLDESIR
T896 EPAPGPVTPAQLPPP
K975-ac AAGPGSGkRRQKEHR
S1023 LGNLDLQSEEIQGRE
A1032 EIQGREKARPDVGGV
S1040 RPDVGGVSKVKTPTA
S1083 APGPPGVSRADMLKL
K1152 KNAKVKGKFRESYLS
T1522 VSWNVARTVKISDPD
S1526 VARTVKISDPDLFKM
Y1561 RAGKKIAYQGRVKDE
  rat

 
- gap
- gap
S10 PAALSGPSGEEGLSP
S16 PSGEEGLSPGGKRRR
T106 SVSPAASTACVPYAP
S123-p PPGLPGTsSSsSSsN
S126-p LPGTsSSsSSsNNTG
S129-p TsSSsSSsNNTGLRG
- gap
S353 GSFRRSESPRPRVSF
T363 PRVSFPKTPEVGQGP
K415 FEEPAEFKILPDGLA
K426 DGLANIMKMLDESIR
T613 EPAPGPVTPAQLPPP
K695 AAGPGSGKRRQKEHR
S743 LGNLDLQSEEIQGRE
A752 EIQGREKARPDVGGA
S760 RPDVGGASKVKTPTT
- under review  
K872 KNAKVKGKFRESYLS
T1242 VSWNVARTVKISDPD
S1246 VARTVKISDPDLFKM
Y1281 RAGKKIAYQGRVKDE
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