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Protein Page:
SCAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SCAP Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Belongs to the WD repeat SCAP family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; integral to membrane
Molecular Function: protein binding; unfolded protein binding; protein complex binding
Biological Process: cholesterol metabolic process; regulation of fatty acid biosynthetic process; positive regulation of low-density lipoprotein receptor biosynthetic process; response to hypoxia; negative regulation of cholesterol biosynthetic process; SREBP-mediated signaling pathway; aging; response to insulin stimulus
Reference #:  Q12770 (UniProtKB)
Alt. Names/Synonyms: KIAA0199; SCAP; SREBF chaperone; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein; Sterol regulatory element-binding protein cleavage-activating protein
Gene Symbols: SCAP
Molecular weight: 139,729 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S206-p EPKTLQTsATLKDLL
0 1 Y243-p ITLVFQHyHAKFLGS
0 1 K454-ub MELADLNkRLPPEAC
0 1 Y730 VLLLLCLYRVLCPRN
0 65 S822-p PGRQRRDsGVGsGLE
0 4 S826-p RRDsGVGsGLEAQEs
0 3 S833-p sGLEAQEsWERLsDG
0 15 S838-p QEsWERLsDGGkAGP
0 1 K842-ub ERLsDGGkAGPEEPG
0 2 G844 LsDGGkAGPEEPGDs
0 18 S851-p GPEEPGDsPPLRHRP
0 1 S904-p HRAVCGRsRDsPGyD
0 4 S907-p VCGRsRDsPGyDFSC
0 1 Y910-p RsRDsPGyDFSCLVQ
0 7 S937-p TPALRPPsPGPVLsQ
0 1 S943-p PsPGPVLsQAPEDEG
0 7 S1041-p LETHTALsPLQFRGT
0 1 R1051 QFRGTPGRGSSPASP
0 1 S1054 GTPGRGSSPASPVYS
0 1 P1058 RGSSPASPVYSSSDT
  mouse

 
S206 EPKTLQTSATLKDLL
Y243 ITLVFQRYHAKFLSS
K454 MELADLNKRLPPESC
Y730-p VLLLLCLyRVLCPRN
S821-p RPGPRRDsCGGGAFE
G825 RRDsCGGGAFETQEN
N832 GAFETQENWERLSDG
S837 QENWERLSDGGKAsP
K841 ERLSDGGKAsPEEPG
S843-p LSDGGKAsPEEPGDs
S850-p sPEEPGDsPPLRRRP
S902 HRVGCGRSRDSGYDF
S905 GCGRSRDSGYDFSRL
Y907 GRSRDSGYDFSRLVQ
S934-p MPALRPPsPGPPLPQ
P940 PsPGPPLPQASQEEG
S1038 LETHTSLSPLQFRGT
R1048-m1 QFRGTPGrGSsPSSs
S1051-p GTPGrGSsPSSsVYS
S1055-p rGSsPSSsVYSSSNT
  rat

 
S206 EPKTLQTSATLKDLL
Y243 ITLVFQRYHAKFLSS
K454 MELADLNKRLPPESC
Y730 VLLLLCLYRVLCPRN
S821 RPGPRRDSCGGGAFE
G825 RRDSCGGGAFEAQEN
N832 GAFEAQENWERLSDG
S837 QENWERLSDGGKASP
K841 ERLSDGGKASPEEPG
S843 LSDGGKASPEEPGDs
S850-p SPEEPGDsPPLRRRP
S902 HRAGCGRSRDSGYDF
S905 GCGRSRDSGYDFSRL
Y907 GRSRDSGYDFSRLVQ
S934 MSALRPPSPGPPLPQ
P940 PSPGPPLPQASQEEG
S1038 LETHTSLSPLQFRGT
R1048 QFRGTPGRGSSPSSP
S1051 GTPGRGSSPSSPVYS
P1055 RGSSPSSPVYSSSNT
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