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Protein Page:
ALPL (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ALPL This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.1; Membrane protein, anchored; Cofactor and Vitamin Metabolism - folate biosynthesis; Phosphatase (non-protein)
Cellular Component: extracellular matrix; extracellular space; integral to membrane; plasma membrane
Molecular Function: protein binding; pyrophosphatase activity; alkaline phosphatase activity; metal ion binding
Biological Process: response to antibiotic; response to vitamin D; response to glucocorticoid stimulus; reproductive developmental process; response to lipopolysaccharide; skeletal development; endochondral ossification
Reference #:  P05186 (UniProtKB)
Alt. Names/Synonyms: Alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphomonoesterase; ALPL; AP-TNAP; APTNAP; FLJ40094; FLJ93059; glycerophosphatase; HOPS; liver/bone/kidney-type alkaline phosphatase; MGC161443; MGC167935; PPBT; tissue-nonspecific alkaline phosphatase; tissue-nonspecific ALP; TNAP; TNSALP
Gene Symbols: ALPL
Molecular weight: 57,305 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below

ALPL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T68 GMGVSTVTAARILKG
0 4 S110-p TNAQVPDsAGTATAy
0 2 Y117-p sAGTATAyLCGVKAN
0 1 K159 RWAKDAGKsVGIVTT
0 1 S160-p WAKDAGKsVGIVTTT
  ALPL iso2  
- gap
S33 TNAQVPDSAGTATAY
Y40 SAGTATAYLCGVKAN
K82 RWAKDAGKSVGIVTT
S83 WAKDAGKSVGIVTTT
  mouse

 
T68-p GMGVSTVtAARILKG
S110-p TNAQVPDsAGTATAY
Y117 sAGTATAYLCGVKAN
K159-a RWAKDAGkSVGIVTT
S160 WAKDAGkSVGIVTTT
  rat

 
T68 GMGVSTVTAARILKG
S110 TNAQVPDSAGTATAy
Y117-p SAGTATAyLCGVKAN
K159 RWAKDAGKSVGIVTT
S160 WAKDAGKSVGIVTTT
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