Home

WIPI2 (human)

Overview WIPI2 Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Interacts with TECPR1. Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Belongs to the WD repeat SVP1 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy Cellular Component: protein complex; cytoplasm; pre-autophagosomal structure membrane; nucleolus; autophagic vacuole; nucleus; cytosol Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding Biological Process: autophagic vacuole fusion; autophagic vacuole formation Reference #:  Q9Y4P8 (UniProtKB) Alt. Names/Synonyms: Atg21; CGI-50; DKFZp434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI2; WIPI49-like protein 2 Gene Symbols: WIPI2 Molecular weight: 49,408 Da Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WIPI2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S85	IVERLFSSSLVAIVS
0	2		K216-u	AFDASGTkLATASEk
0	1		K223-a	kLATASEkGTVIRVF
0	1		K223-u	kLATASEkGTVIRVF
0	2		K237-u	FSIPEGQkLFEFRRG
0	1		T292-p	PEEPTTWtGYFGKVL
0	1		S308-p	ASTSYLPsQVTEMFN
0	1		K341	CSLATIQKIPRLLVG
0	6		S412	GKGTYVPSsPtRLAY
0	14		S413-p	KGTYVPSsPtRLAYT
0	4		T415-p	TYVPSsPtRLAYTDD

	mouse
S67	IVERLFSSSLVAIVS
K198-u	AFDASGTkLATASEK
K205	kLATASEKGTVIRVF
K205	kLATASEKGTVIRVF
K219	FSIPEGQKLFEFRRG
T274	PEEPTTWTGYFGKVL
S290	ASTSYLPSQVTEMFN
K323-u	CSLTTIQkIPRLLVG
S394-p	AKGAYVPssPtRLGK
S395-p	KGAYVPssPtRLGKG
T397-p	AYVPssPtRLGKGQD

	rat
S67-p	IVERLFSsSLVAIVS
K198	AFDASGTKLATASEK
K205	KLATASEKGTVIRVF
K205	KLATASEKGTVIRVF
K219	FSIPEGQKLFEFRRG
T274	PEEPTTWTGYFGKVL
S290	ASTSYLPSQVTEMFN
K323	CSLTTIQKIPRLLVG
S394-p	AKGAYVPssPTRLGK
S395-p	KGAYVPssPTRLGKG
T397	AYVPssPTRLGKGQD

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.