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Protein Page:
WIPI2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WIPI2 Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Interacts with TECPR1. Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Belongs to the WD repeat SVP1 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Cellular Component: protein complex; pre-autophagosomal structure membrane; cytoplasm; nucleolus; autophagic vacuole; cytosol; nucleus
Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding
Biological Process: autophagic vacuole fusion; autophagic vacuole formation
Reference #:  Q9Y4P8 (UniProtKB)
Alt. Names/Synonyms: Atg21; CGI-50; DKFZp434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI2; WIPI49-like protein 2
Gene Symbols: WIPI2
Molecular weight: 49,408 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WIPI2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S85 IVERLFSSSLVAIVS
0 2 K216-ub AFDASGTkLATASEk
0 1 K223-ac kLATASEkGTVIRVF
0 1 K223-ub kLATASEkGTVIRVF
0 2 K237-ub FSIPEGQkLFEFRRG
0 1 T292-p PEEPTTWtGYFGKVL
0 1 S308-p ASTSYLPsQVTEMFN
0 1 K341 CSLATIQKIPRLLVG
0 7 S412-p GKGTYVPssPtRLAY
0 19 S413-p KGTYVPssPtRLAYT
0 5 T415-p TYVPssPtRLAYTDD
13571 : Phospho-WIPI2 (Ser413) Antibody
  WIPI2 iso5  
T21-p PGCPHPMtTCsAGtL
S24-p PHPMtTCsAGtLsAV
T27-p MtTCsAGtLsAVPCV
S29-p TCsAGtLsAVPCVsP
S35-p LsAVPCVsPRQVFVF
S80 IVERLFSSSLVAIVS
K211 AFDASGTKLATASEK
K218 KLATASEKGTVIRVF
K218 KLATASEKGTVIRVF
K232 FSIPEGQKLFEFRRG
T287 PEEPTTWTGYFGKVL
S303 ASTSYLPSQVTEMFN
K336 CSLATIQKIPRLLVG
- gap
- gap
- gap
  mouse

 
- gap
- gap
- gap
- gap
- gap
S67 IVERLFSSSLVAIVS
K198-ub AFDASGTkLATASEK
K205 kLATASEKGTVIRVF
K205 kLATASEKGTVIRVF
K219 FSIPEGQKLFEFRRG
T274 PEEPTTWTGYFGKVL
S290 ASTSYLPSQVTEMFN
K323-ub CSLTTIQkIPRLLVG
S394-p AKGAYVPssPtRLGK
S395-p KGAYVPssPtRLGKG
T397-p AYVPssPtRLGKGQD
13571 : Phospho-WIPI2 (Ser413) Antibody
  rat

 
- gap
- gap
- gap
- gap
- gap
S67-p IVERLFSsSLVAIVS
K198 AFDASGTKLATASEK
K205 KLATASEKGTVIRVF
K205 KLATASEKGTVIRVF
K219 FSIPEGQKLFEFRRG
T274 PEEPTTWTGYFGKVL
S290 ASTSYLPSQVTEMFN
K323 CSLTTIQKIPRLLVG
S394-p AKGAYVPssPTRLGK
S395-p KGAYVPssPTRLGKG
T397 AYVPssPTRLGKGQD
13571 : Phospho-WIPI2 (Ser413) Antibody
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