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Protein Page:
TRRAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRRAP Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor; Kinase, protein; Protein kinase, atypical; ATYPICAL group; PIKK family; TRRAP subfamily
Cellular Component: nucleoplasm; PCAF complex; NuA4 histone acetyltransferase complex; nucleus
Molecular Function: protein binding; transcription coactivator activity; transcription cofactor activity; phosphotransferase activity, alcohol group as acceptor
Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; mitotic cell cycle checkpoint; histone acetylation; histone deubiquitination
Reference #:  Q9Y4A5 (UniProtKB)
Alt. Names/Synonyms: 350/400 kDa PCAF-associated factor; FLJ10671; PAF350/400; PAF400; STAF40; TR-AP; Tra1; Tra1 homolog; Transformation/transcription domain-associated protein; TRRAP
Gene Symbols: TRRAP
Molecular weight: 437,600 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRRAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T6 __MAFVATQGATVVD
0 1 T10 FVATQGATVVDQTTL
0 1 T16 ATVVDQTTLMKKYLQ
0 1 Y21 QTTLMKKYLQFVAAL
0 1 T29 LQFVAALTDVNTPDE
0 1 T33 AALTDVNTPDETKLK
0 1 T37 DVNTPDETKLKMMQE
0 1 S46 LKMMQEVSENFENVT
0 1 S55 NFENVTSSPQYSTFL
0 1 Y58 NVTSSPQYSTFLEHI
0 1 S59 VTSSPQYSTFLEHII
0 1 T60 TSSPQYSTFLEHIIP
0 1 K84-ub EVQFLQEkPAQQLRK
0 1 T209-p PEREDSEtRtHsIIP
0 1 T211-p REDSEtRtHsIIPRG
0 1 S213-p DSEtRtHsIIPRGSL
0 1 S318-p KGMLQLLsNCPAEtA
0 1 T324-p LsNCPAEtAHLRKEL
0 1 K353-ub QFIPCMDkLFDESIL
0 1 S434-p VDCIRSKsEQESGNG
0 1 K579-ub EAQFIPNkQLQPKET
0 1 S663-p PYMVERIsKNYALQI
0 1 S818-p LTVPVRLsSLLPYLP
0 2 Y862-p NLQPDFLyDHIQPVR
0 1 S886 TLRNPADSISHVAYR
0 1 Y892 DSISHVAYRVLGkFG
0 2 K897-ub VAYRVLGkFGGSNRK
0 1 Y914-p KESQKLHyVVtEVQG
0 1 T917-p QKLHyVVtEVQGPsI
0 1 S923-p VtEVQGPsITVEFsD
0 1 S929-p PsITVEFsDCKAsLQ
0 1 S934-p EFsDCKAsLQLPMEK
0 1 Y1007-p NVIISHRyKAQDTPA
0 1 S1044-p SALPFVAsLIRHYTM
0 2 S1263-p VRKQAMHsLQVLAQV
0 1 T1271-p LQVLAQVtGKSVTVI
0 1 Y1437-p LLMMLGDyRSLTLNV
0 1 S1552-p AMLIEAGsPFREPLI
0 1 T1622-p LLPGGAQtAVRPGsP
0 4 S1628-p QtAVRPGsPSTStMR
0 1 S1630 AVRPGsPSTStMRLD
0 4 S1632 RPGsPSTStMRLDLQ
0 1 T1633-p PGsPSTStMRLDLQF
0 1 K1691-m1 NMAATNWkEPKLLAY
0 1 K1769-ub PNFGDELkAKVLQHI
0 1 T1999-p LGFTPSVtIEQRRLA
0 1 K2022-ub KWELQRIkDQQPDSD
0 1 K2047-ub NSVSSSIkRGLsVDS
0 24 S2051-p SSIkRGLsVDSAQEV
0 1 T2063-p QEVKRFRtATGAIsA
0 2 S2069-p RtATGAIsAVFGRsQ
0 4 S2075-p IsAVFGRsQsLPGAD
0 16 S2077-p AVFGRsQsLPGADSL
0 1 T2132-p RCVNLLKtALRPDMW
0 2 K2235-ac STSSVASkYEELECL
0 1 S2284-p SACSNNPsYIDRLIS
0 1 T2333-p LSLELVKtRLAVMSM
0 1 K2405-m1 KMMTYIEkRFPEDLE
0 1 K2438-ub SGSELTAkLEPAFLS
0 1 S2530-p NVINLADsHDRAAFA
0 2 K2543-ac FAMVTHVkQEPRERE
0 1 K2597-ub MLTNRHDkFLDtLRE
0 1 T2601-p RHDkFLDtLREVKTG
0 1 K2638-ub QLFPRLWkILSDRQQ
0 1 S2913 RLVEMASSLAIREWR
0 1 K2972-ub HDMKTVVkTWRNRLP
0 2 K3050-ub QYGKIARkQGLVNVA
0 1 K3078-ac PIVDCFQkIRQQVKC
0 1 Y3122-p KEMTAEFyALKGMFL
0 1 S3255-p KLLLNLIsQVGRVYP
0 1 K3285 IEQRERYKSDPGPIR
0 1 K3372-ub PHTLNFVkKLVSTFG
0 1 K3415-ub AQDPVFQkLkGQFTT
0 1 K3417-ub DPVFQkLkGQFTTDF
0 1 K3442-ub HNLISKLkKWIKILE
0 1 S3469-p EEKCRFLsNFSAQTA
0 1 K3488-ub PGEFLMPkPTHYYIK
0 2 Y3526-p RGHNGKIyPYLVMND
0 1 K3598-ub LSLVEIYkQRCAKKG
0 1 K3639-ub QVLRDILkEVQSNMV
0 1 Y3709-p TGKLNVAyFRFDIND
  TRRAP iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S32 KGMLQLLSNCPAETA
T38 LSNCPAETAHLRKEL
K67 QFIPCMDKLFDESIL
S148 VDCIRSKSEQESGNG
K293 EAQFIPNKQLQPKET
S377 PYMVERISKNYALQI
S532 LTVPVRLSSLLPYLP
Y576 NLQPDFLYDHIQPVR
S600 TLRNPADSISHVAYR
Y606 DSISHVAYRVLGKFG
K611 VAYRVLGKFGGSNRK
Y628 KESQKLHYVVTEVQG
T631 QKLHYVVTEVQGPSI
S637 VTEVQGPSITVEFSD
S643 PSITVEFSDCKASLQ
S648 EFSDCKASLQLPMEK
Y721 NVIISHRYKAQDTPA
S758 SALPFVASLIRHYTM
S977 VRKQAMHSLQVLAQV
T985 LQVLAQVTGKSVTVI
Y1151 LLMMLGDYRSLTLNV
S1273 AMLIEAGSPFREPLI
T1343 LLPGGAQTAVRPGSP
S1349 QTAVRPGSPSTSTMR
S1351 AVRPGSPSTSTMRLD
S1353 RPGSPSTSTMRLDLQ
T1354 PGSPSTSTMRLDLQF
K1412 NMAATNWKEPKLLAY
K1490 PNFGDELKAKVLQHI
T1720 LGFTPSVTIEQRRLA
K1743 KWELQRIKDQQPDSD
K1768 NSVSSSIKRGLSVDS
S1772 SSIKRGLSVDSAQEV
T1784 QEVKRFRTATGAISA
S1790 RTATGAISAVFGRSQ
S1796 ISAVFGRSQSLPGAD
S1798 AVFGRSQSLPGADSL
T1853 RCVNLLKTALRPDMW
K1956 STSSVASKYEELECL
S2005 SACSNNPSYIDRLIS
T2054 LSLELVKTRLAVMSM
K2126 KMMTYIEKRFPEDLE
K2159 SGSELTAKLEPAFLS
S2251 NVINLADSHDRAAFA
K2264 FAMVTHVKQEPRERE
K2318 MLTNRHDKFLDTLRE
T2322 RHDKFLDTLREVKTG
K2359 QLFPRLWKILSDRQQ
S2634 RLVEMASSLAIREWR
K2693 HDMKTVVKTWRNRLP
K2760 QYGKIARKQGLVNVA
K2788 PIVDCFQKIRQQVKC
Y2832 KEMTAEFYALKGMFL
S2965 KLLLNLISQVGRVYP
K2995-ub IEQRERYkSDSGQQQ
K3100 PHTLNFVKKLVSTFG
K3143 AQDPVFQKLKGQFTT
K3145 DPVFQKLKGQFTTDF
K3170 HNLISKLKKWIKILE
S3197 EEKCRFLSNFSAQTA
K3216 PGEFLMPKPTHYYIK
Y3254 RGHNGKIYPYLVMND
K3326 LSLVEIYKQRCAKKG
K3367 QVLRDILKEVQSNMV
Y3437 TGKLNVAYFRFDIND
  mouse

 
T6-p __MAFVAtQGAtVVD
T10-p FVAtQGAtVVDQTtL
T16-p AtVVDQTtLMKKyLQ
Y21-p QTtLMKKyLQFVAAL
T29-p LQFVAALtDVNtPDE
T33-p AALtDVNtPDEtKLK
T37-p DVNtPDEtKLKMMQE
S46-p LKMMQEVsENFENVT
S55-p NFENVTSsPQystFL
Y58-p NVTSsPQystFLEHI
S59-p VTSsPQystFLEHII
T60-p TSsPQystFLEHIIP
K84 EVQFLQEKPAQQLRK
T209 PEREDSETRTHSIIP
T211 REDSETRTHSIIPRG
S213 DSETRTHSIIPRGSL
S318 KGMLQLLSNCPAETA
T324 LSNCPAETAHLRKEL
K353 QFIPCMDKLFDESIL
S434 VDCIRSKSEQESGNG
K579 GAQFIPNKQLQPKET
S663 PYMVERISKNYALQI
S818 LTVPVRLSSLLPYLP
Y862 NLQPDFLYDHIQPVR
S886-p TLRNPADsISHVAyR
Y892-p DsISHVAyRVLGkFG
K897-ub VAyRVLGkFGGSNRK
Y914 KESQKLHYVVTEVQG
T917 QKLHYVVTEVQGPSI
S923 VTEVQGPSITVEFSD
S929 PSITVEFSDCKASLQ
S934 EFSDCKASLQLPMEK
Y1007 NVIISHRYKAQDTPA
S1044 SALPFVASLIRHYTM
S1263 VRKQAMHSLQVLAQV
T1271 LQVLAQVTGKSVTVI
Y1437 LLMMLGDYRSLTLNV
S1534 AMLIEAGSPFREPLI
T1604 LLPGGAQTAVRPGSP
S1610 QTAVRPGSPsTsNMR
S1612-p AVRPGSPsTsNMRLD
S1614-p RPGSPsTsNMRLDLQ
N1615 PGSPsTsNMRLDLQF
K1673 NMAATNWKEPKLLAF
K1751 PNFGDELKAKVLQHI
T1981 LGFTPSVTIEQRRLA
K2004 KWELQRIKDQQPDSD
K2027 GVNSVSIKRGLsVDS
S2031-p VSIKRGLsVDSAQEV
A2043 QEVKRFRAATGAISA
S2049 RAATGAISAVFGRsQ
S2055-p ISAVFGRsQsLPGAD
S2057-p AVFGRsQsLPGADSL
T2112 RCVNLLKTALRPDMW
K2215 STSSVASKYEELECL
S2264 SACCNNPSYIDRLIS
T2314 LSLDLVKTRLAVMSM
K2386 KMMTYIEKRFPEDLE
K2419 SGSELTAKLEPAFLS
S2511 NVINLADSHDRAAFA
K2524 FAMVTHVKQEPRERE
K2578 MLTNRHDKFLDTLRE
T2582 RHDKFLDTLREVKTG
K2619 QLFPRLWKILSDRQQ
S2894-p RLVEMASsLAIREWR
K2953 HDMKTVVKTWRNRLP
K3020 QYGKIARKQGLVNVA
K3048 PIVDCFQKIRQQVKC
Y3092 KEMTAEFYALKGMFL
S3225 KLLLNLISQVGRVYP
K3255 IEQRERYKSDSGQQQ
K3360 PHTLNFVKKLVSTFG
K3403 AQDPVFQKLKGQFTT
K3405 DPVFQKLKGQFTTDF
K3430 HNLISKLKKWIKILE
S3457 EEKCRFLSNFSAQTA
K3476 PGEFLMPKPTHYYIK
Y3514 RGHNGKIYPYLVMND
K3586 LSLVEIYKQRCAKKG
K3627 QVLRDILKEVQSNMV
Y3697 TGKLNVAYFRFDIND
  rat

 
T6 __MAFVATQGATVVD
T10 FVATQGATVVDQTTL
T16 ATVVDQTTLMKKYLQ
Y21 QTTLMKKYLQFVAAL
T29 LQFVAALTDVNTPDE
T33 AALTDVNTPDETKLK
T37 DVNTPDETKLKMMQE
S46 LKMMQEVSENFENVT
S55 NFENVTSSPQYSTFL
Y58 NVTSSPQYSTFLEHI
S59 VTSSPQYSTFLEHII
T60 TSSPQYSTFLEHIIP
K84 EVQFLQEKPAQQLRK
T209 PEREDSETRTHSIIP
T211 REDSETRTHSIIPRG
S213 DSETRTHSIIPRGSL
S318 KGMLQLLSNCPAETA
T324 LSNCPAETAHLRKEL
K353 QFIPCMDKLFDESIL
S434 VDCIRSKSEQESGNG
K580 EAQFIPNKQLQPKET
S664 PYMVERISKNYALQI
S819 LTVPVRLSSLLPYLP
Y863 NLQPDFLYDHIQPVR
S887 TLRNPADSISHVAYR
Y893 DSISHVAYRVLGKFG
K898 VAYRVLGKFGGSNRK
Y915 KESQRLHYVVTEVQG
T918 QRLHYVVTEVQGPSI
S924 VTEVQGPSITVEFSD
S930 PSITVEFSDCKASLQ
S935 EFSDCKASLQLPMEK
Y1008 SVIISHRYKAQDTPA
S1045 SALPFVASLIRHYTM
S1264 VRKQAMHSLQVLAQV
T1272 LQVLAQVTGKSVTVI
Y1438 LLMMLGDYRSLTLNV
S1535 AMLIEAGSPFREPLI
T1605 LLPGGAQTAVRPGSP
S1611 QTAVRPGSPSTSNMR
S1613 AVRPGSPSTSNMRLD
S1615 RPGSPSTSNMRLDLQ
N1616 PGSPSTSNMRLDLQF
K1674 NMAATNWKEPKLLAF
K1752 PNFGDELKAKVLQHI
T1982 LGFTPSVTIEQRRLA
K2005 KWELQRIKDQQPDSD
K2028 GVNSVSIKRGLsVDS
S2032-p VSIKRGLsVDSAQEV
A2044 QEVKRFRAATGAISA
S2050 RAATGAISAVFGRSQ
S2056 ISAVFGRSQSLPGAD
S2058 AVFGRSQSLPGADSL
T2113 RCVNLLKTALRPDMW
K2216 STSSVASKYEELECL
S2265 SACCNNPSYIDRLIS
T2315 LSLDLVKTRLAVMSM
K2387 KMMTYIEKRFPEDLE
K2420 SGSELTAKLEPAFLS
S2512 NVINLADSHDRAAFA
K2525 FAMVTHVKQEPRERE
K2579 MLTNRHDKFLDTLRE
T2583 RHDKFLDTLREVKTG
K2620 QLFPRLWKILSDRQQ
S2893 RLVEMASSLAIREWR
K2952 HDMKTVVKTWRNRLP
K3019 QYGKIARKQGLVNVA
K3047 PIVDCFQKIRQQVKC
Y3091 KEMTAEFYALKGMFL
S3224 KLLLNLISQVGRVYP
K3254 IEQRERYKSDSGQQQ
K3359 PHTLNFVKKLVSTFG
K3402 AQDPVFQKLKGQFTT
K3404 DPVFQKLKGQFTTDF
K3429 HNLISKLKKWIKILE
S3456 EEKCRFLSNFSAQTA
K3475 PGEFLMPKPTHYYIK
Y3513 RGHNGKIYPYLVMND
K3585 LSLVEIYKQRCAKKG
K3626 QVLRDILKEVQSNMV
Y3696 TGKLNVAYFRFDIND
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