|
PDGFB
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted |
|
Cellular Component: Golgi membrane; cell surface; basolateral plasma membrane; endoplasmic reticulum lumen; cytoplasm; extracellular region
|
|
Molecular Function: collagen binding; protein binding; eukaryotic cell surface binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; superoxide-generating NADPH oxidase activator activity; cell surface binding
|
|
Biological Process: embryonic placenta development; positive regulation of cyclin-dependent protein kinase activity; peptidyl-tyrosine phosphorylation; heart development; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; platelet-derived growth factor receptor signaling pathway; positive regulation of fibroblast growth factor receptor signaling pathway; cell projection biogenesis; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; response to estradiol stimulus; response to insulin stimulus; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of fibroblast proliferation; platelet degranulation; positive regulation of MAPKKK cascade; positive regulation of glomerular filtration; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; response to wounding; hemopoiesis; cell growth; DNA replication; negative regulation of cell migration; substrate-bound cell migration; response to drug; platelet activation; positive regulation of mitosis; positive regulation of chemotaxis; activation of protein kinase B; positive regulation of blood vessel endothelial cell migration; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division; activation of protein kinase activity; response to hypoxia; positive regulation of endothelial cell proliferation; blood coagulation; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis; positive regulation of DNA replication; positive regulation of cell migration
|
|
Reference #:
P01127 (UniProtKB)
|
| Alt. Names/Synonyms: becaplermin; c-sis; FLJ12858; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF2; PDGFB; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, B chain; Platelet-derived growth factor, beta polypeptide (oncogene SIS); Proto-oncogene c-Sis; SIS; SSV |
| Gene Symbols: PDGFB |
|
Molecular weight: 27,283 Da
|
|
Basal Isoelectric point: 9.39
Predict pI for various phosphorylation states
|
|
CST Pathways:
Angiogenesis
|
