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Protein Page:
TFEB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TFEB Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: protein heterodimerization activity; transcription factor activity
Biological Process: embryonic placenta development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; humoral immune response; positive regulation of autophagy
Reference #:  P19484 (UniProtKB)
Alt. Names/Synonyms: ALPHATFEB; BHLHE35; Class E basic helix-loop-helix protein 35; T-cell transcription factor EB; TCFEB; TFEB; Transcription factor EB
Gene Symbols: TFEB
Molecular weight: 52,865 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TFEB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 R8-m1 MASRIGLrMQLMREQ
0 7 R8-m2 MASRIGLrMQLMREQ
0 1 S61 NTPVHFQSPPPVPGE
0 1 S74-p GEVLKVQsYLENPTS
0 1 Y95-p QHQKVREyLsETyGN
0 4 S97-p QKVREyLsETyGNKF
0 1 Y100-p REyLsETyGNKFAAH
0 13 S109-p NKFAAHIsPAQGsPK
0 15 S114-p HIsPAQGsPKPPPAA
0 18 S122-p PKPPPAAsPGVRAGH
0 1 S133-p RAGHVLSssAGNsAP
0 1 S134-p AGHVLSssAGNsAPN
0 8 S138-p LSssAGNsAPNsPMA
1 8 S142-p AGNsAPNsPMAMLHI
0 2 T183-p PEMQMPNtLPLSSSH
0 1 S187 MPNtLPLSSSHLNVY
0 1 S188 PNtLPLSSSHLNVYS
0 1 S189 NtLPLSSSHLNVYSS
0 1 Y194 SSSHLNVYSSDPQVT
0 1 S195 SSHLNVYSSDPQVTA
0 1 T201 YSSDPQVTASLVGVT
0 1 S203 SDPQVTASLVGVTSS
3 0 S211-p LVGVTSSsCPADLTQ
0 3 S227-p RELTDAEsRALAKER
0 3 T330-p ARVHGLPttsPsGMN
0 2 T331-p RVHGLPttsPsGMNM
0 14 S332-p VHGLPttsPsGMNMA
0 6 S334-p GLPttsPsGMNMAEL
0 4 S423-p PLAPGHGsPFPSLsK
0 1 S429-p GsPFPSLsKKDLDLM
0 1 S441-p DLMLLDDsLLPLASD
0 1 S452 LASDPLLSTMsPEAS
0 2 S455-p DPLLSTMsPEASKAS
1 0 S462 sPEASKASsRRssFs
1 2 S463-p PEASKASsRRssFsM
0 8 S466-p SKASsRRssFsMEEG
1 15 S467-p KASsRRssFsMEEGD
1 6 S469-p SsRRssFsMEEGDVL
  TFEB iso2  
R8 MASRIGLRMQLMREQ
R8 MASRIGLRMQLMREQ
S61-p NTPVHFQsPPPVPGE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T98 PEMQMPNTLPLSSSH
S102 MPNTLPLSSSHLNVY
S103 PNTLPLSSSHLNVYS
S104 NTLPLSSSHLNVYSS
Y109 SSSHLNVYSSDPQVT
S110 SSHLNVYSSDPQVTA
T116 YSSDPQVTASLVGVT
S118 SDPQVTASLVGVTSS
S126 LVGVTSSSCPADLTQ
S142 RELTDAESRALAKER
T245 ARVHGLPTTSPSGMN
T246 RVHGLPTTSPSGMNM
S247 VHGLPTTSPSGMNMA
S249 GLPTTSPSGMNMAEL
S338 PLAPGHGSPFPSLSK
S344 GSPFPSLSKKDLDLM
S356 DLMLLDDSLLPLASD
S367 LASDPLLSTMSPEAS
S370 DPLLSTMSPEASKAS
S377 SPEASKASSRRSSFS
S378 PEASKASSRRSSFSM
S381 SKASSRRSSFSMEEG
S382 KASSRRSSFSMEEGD
S384 SSRRSSFSMEEGDVL
  mouse

 
R8 MASRIGLRMQLMREQ
R8-m2 MASRIGLrMQLMREQ
S60 NTPVHFQSPPPVPGE
S73 GEVLKVQSYLENPTS
Y94 QHQKVREYLSETYGN
S96 QKVREYLSETYGNKF
Y99 REYLSETYGNKFAAH
S108-p NKFAAHVsPAQGsPK
S113-p HVsPAQGsPKPAPAA
S121-p PKPAPAAsPGVRAGH
T132 RAGHVLSTSAGNsAP
S133 AGHVLSTSAGNsAPN
S137-p LSTSAGNsAPNsPMA
S141-p AGNsAPNsPMAMLHI
T182-p PEMQMPNtLPLsssH
S186-p MPNtLPLsssHLNVy
S187-p PNtLPLsssHLNVys
S188-p NtLPLsssHLNVysG
Y193-p sssHLNVysGDPQVt
S194-p ssHLNVysGDPQVtA
T200-p ysGDPQVtAsMVGVT
S202-p GDPQVtAsMVGVTSS
S210 MVGVTSSSCPADLTQ
S226-p RELTDAEsRALAKER
T329-p ARVHGLPttsPsGVN
T330-p RVHGLPttsPsGVNM
S331-p VHGLPttsPsGVNMA
S333-p GLPttsPsGVNMAEL
S422 TLGTEHGSPFPNLSK
S428 GSPFPNLSKKDLDLM
S440 DLMLLDDSLLPLASD
S451-p LASDPLFsTMSPEAS
S454 DPLFsTMSPEASKAs
S461-p SPEASKAssRRssFs
S462-p PEASKAssRRssFsM
S465-p SKAssRRssFsMEEG
S466-p KAssRRssFsMEEGD
S468-p ssRRssFsMEEGDVL
  rat

 
R67 MASRIGLRMQLMREQ
R67 MASRIGLRMQLMREQ
S120 NTPVHFQSPPPVPGE
S133 GEVLKVQSYLENPTS
Y154 QHQKVREYLSETYGN
S156 QKVREYLSETYGNKF
Y159 REYLSETYGNKFAAH
S168-p NKFAAHVsPAQGsPK
S173-p HVsPAQGsPKPPPAA
S181-p PKPPPAAsPGVRAGH
T192 RAGHVLSTSAGNsAP
S193 AGHVLSTSAGNsAPN
S197-p LSTSAGNsAPNsPMA
S201-p AGNsAPNsPMAMLHI
T242 PEMQMPNTLPLSSSH
S246 MPNTLPLSSSHLNVY
S247 PNTLPLSSSHLNVYS
S248 NTLPLSSSHLNVYSG
Y253 SSSHLNVYSGDPQVT
S254 SSHLNVYSGDPQVTA
T260 YSGDPQVTASLVGVT
S262 GDPQVTASLVGVTSS
S270 LVGVTSSSCPADLTQ
S286 RELTDAESRALAKER
T389 ARVHGLPTTsPSGVN
T390 RVHGLPTTsPSGVNM
S391-p VHGLPTTsPSGVNMA
S393 GLPTTsPSGVNMAEL
S482 PLGTEHGSPFPNLSK
S488 GSPFPNLSKKDLDLM
S500 DLMLLDDSLLPLASD
S511 LASDPLFSTMsPEAS
S514-p DPLFSTMsPEASKAS
S521 sPEASKASSRRssFs
S522 PEASKASSRRssFsM
S525-p SKASSRRssFsMEEG
S526-p KASSRRssFsMEEGD
S528-p SSRRssFsMEEGDVL
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