Home

WTX (human)

Overview WTX a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and adult kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. Cellular Component: plasma membrane; cytosol; nucleus Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-catenin binding Biological Process: Wnt receptor signaling pathway Reference #:  Q5JTC6 (UniProtKB) Alt. Names/Synonyms: AMER1; F123B; FAM123B; family with sequence similarity 123B; FLJ39827; OSCS; Protein FAM123B; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX Gene Symbols: AMER1 Molecular weight: 124,029 Da Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WTX

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 300373 300647  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T41-p	AEATEGPtSEPSSSG
0	1		S91-p	GSSKKGLsKSKTHDG
0	1		S161-p	AVAEKFPsMPKPKKG
0	1		K195-a	EQSEPGAkGPERVRA
1	1		S240	DAPGPKVSPtPEPsP
1	1		T242-p	PGPKVSPtPEPsPPA
1	1		S246-p	VSPtPEPsPPATEKM
0	1		S267-p	KPMEACAsAHVQPKP
1	0		S280	KPAPEASSLEEPHsP
1	0		S286-p	SSLEEPHsPETGEKV
1	0		T317	SLLFGDVTSLKSFDS
1	0		S324	TSLKSFDSLTGCGDI
1	0		T326	LKSFDSLTGCGDIIA
1	0		T429	NLGYHPTTSPGHHGY
1	0		S430	LGYHPTTSPGHHGYM
1	0		S518	PDDSLENSPPGDDCL
1	0		Y526	PPGDDCLYDLHGRSS
1	0		S548	NFEPFLSSRPPGAME
1	0		T556	RPPGAMETEEERLVT
0	4		Y570-p	TIQKQLLyWELRREQ
1	0		S683	ISHRGITSAFPTTAS
1	0		-	gap
0	1		Y854-p	HKHAFNNyHSRFYQG
0	2		S868-p	GLPWGVSsLPRYLGL
0	1		S1006-p	MTMSISLsVPESRAP
0	1		S1125-p	ASLATSYsstAMNGN
0	1		S1126-p	SLATSYsstAMNGNL
0	1		T1127-p	LATSYsstAMNGNLA

	WTX iso2
T41	AEATEGPTSEPSSSG
S91	GSSKKGLSKSKTHDG
S161	AVAEKFPSMPKPKKG
K195	EQSEPGAKGPERVRA
S240-p	DAPGPKVsPtPEPsP
T242-p	PGPKVsPtPEPsPPA
S246-p	VsPtPEPsPPATEKM
S267	KPMEACASAHVQPKP
S280-p	KPAPEASsLEEPHsP
S286-p	SsLEEPHsPETGEKV
T317-p	SLLFGDVtSLKSFDs
S324-p	tSLKSFDsLtGCGDI
T326-p	LKSFDsLtGCGDIIA
T429-p	NLGYHPTtsPGHHGY
S430-p	LGYHPTtsPGHHGYM
S518-p	PDDSLENsPPGDDCL
Y526-p	PPGDDCLyDLHGRSS
S548-p	NFEPFLSsRPPGAME
T556-p	RPPGAMEtEEERLVT
Y570	TIQKQLLYWELRREQ
S683-p	ISHRGITsAFPTTAS
T803-p	QVTQACGtW______
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
T41	TEATEGPTSEPPLSG
N91	VSSKKSLNKSKTHDG
S161	AGVEKVPSVHKPKKS
K195	DQSVPGAKELEGART
S239-p	DAPGPKMsPAQVHFS
A241	PGPKMsPAQVHFSPT
F245	MsPAQVHFSPTTEKA
S266	KLTRTCASEFMQPKP
S279	KPVLEGGSLEEPHTS
T285	GSLEEPHTSETEGKV
T316	SLLFGDVTSLKSFDS
S323	TSLKSFDSLTGCGDI
T325	LKSFDSLTGCGDIIA
I449	NLGYHTAISPSHQGY
S450	LGYHTAISPSHQGYM
S538	PDDSLEHSPPGDDCL
Y546	PPGDDCLYDLRGRNS
S567	LNLEPFSSRPPGAME
T575	RPPGAMETEEERLVT
Y589	TIQKQLLYWELRREQ
S687	TSHRGTTSAFPATSS
-	gap
Y858	HKHAFNSYHSRFYQG
S872-p	GLPWGVSsLPRYLGL
P1009	VAMPVSVPGRTPGDS
S1122	ASLSTSYSSTAMNGN
S1123	SLSTSYSSTAMNGNL
T1124	LSTSYSSTAMNGNLA

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.