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Protein Page:
WTX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WTX a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and adult kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Cellular Component: plasma membrane; nucleus; cytosol
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; beta-catenin binding
Biological Process: Wnt receptor signaling pathway
Reference #:  Q5JTC6 (UniProtKB)
Alt. Names/Synonyms: AMER1; F123B; FAM123B; family with sequence similarity 123B; FLJ39827; OSCS; Protein FAM123B; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX
Gene Symbols: AMER1
Molecular weight: 124,029 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WTX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T41-p AEATEGPtSEPSSSG
0 1 S91-p GSSKKGLsKSKTHDG
0 1 S161-p AVAEKFPsMPKPKKG
0 1 K195-ac EQSEPGAkGPERVRA
1 2 S240-p DAPGPKVsPtPEPsP
1 3 T242-p PGPKVsPtPEPsPPA
1 6 S246-p VsPtPEPsPPAtEKM
0 1 T250-p PEPsPPAtEKMACKD
0 1 S267-p KPMEACAsAHVQPKP
1 1 S280-p KPAPEASsLEEPHsP
1 1 S286-p SsLEEPHsPETGEKV
1 0 T317-p SLLFGDVtSLKSFDS
1 0 S324 tSLKSFDSLTGCGDI
1 0 T326 LKSFDSLTGCGDIIA
1 0 T429 NLGYHPTTSPGHHGY
1 0 S430 LGYHPTTSPGHHGYM
1 0 S518 PDDSLENSPPGDDCL
1 0 Y526 PPGDDCLYDLHGRSS
1 0 S548 NFEPFLSSRPPGAME
1 0 T556 RPPGAMETEEERLVT
0 5 Y570-p TIQKQLLyWELRREQ
1 0 S683 ISHRGITSAFPTTAS
0 1 S749-p RRAYPTYsPPEDPEE
1 0 - gap
0 1 Y854-p HKHAFNNyHSRFYQG
0 3 S868-p GLPWGVSsLPRYLGL
0 1 S895-p ALNRRSRsLDTAETL
0 1 S1006-p MTMSISLsVPESRAP
0 1 S1125-p ASLATSYsstAMNGN
0 1 S1126-p SLATSYsstAMNGNL
0 1 T1127-p LATSYsstAMNGNLA
  WTX iso2  
T41 AEATEGPTSEPSSSG
S91 GSSKKGLSKSKTHDG
S161 AVAEKFPSMPKPKKG
K195 EQSEPGAKGPERVRA
S240-p DAPGPKVsPtPEPsP
T242-p PGPKVsPtPEPsPPA
S246-p VsPtPEPsPPATEKM
T250 PEPsPPATEKMACKD
S267 KPMEACASAHVQPKP
S280-p KPAPEASsLEEPHsP
S286-p SsLEEPHsPETGEKV
T317-p SLLFGDVtSLKSFDs
S324-p tSLKSFDsLtGCGDI
T326-p LKSFDsLtGCGDIIA
T429-p NLGYHPTtsPGHHGY
S430-p LGYHPTtsPGHHGYM
S518-p PDDSLENsPPGDDCL
Y526-p PPGDDCLyDLHGRSS
S548-p NFEPFLSsRPPGAME
T556-p RPPGAMEtEEERLVT
Y570 TIQKQLLYWELRREQ
S683-p ISHRGITsAFPTTAS
S749 RRAYPTYSPPEDPEE
T803-p QVTQACGtW______
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
  mouse

 
T41 TEATEGPTSEPPLSG
N91 VSSKKSLNKSKTHDG
S161 AGVEKVPSVHKPKKS
K195 DQSVPGAKELEGART
S239-p DAPGPKMsPAQVHFS
A241 PGPKMsPAQVHFSPT
F245 MsPAQVHFSPTTEKA
T249 QVHFSPTTEKAACKN
S266 KLTRTCASEFMQPKP
S279 KPVLEGGSLEEPHTS
T285 GSLEEPHTSETEGKV
T316 SLLFGDVTSLKSFDS
S323 TSLKSFDSLTGCGDI
T325 LKSFDSLTGCGDIIA
I449 NLGYHTAISPSHQGY
S450 LGYHTAISPSHQGYM
S538 PDDSLEHSPPGDDCL
Y546 PPGDDCLYDLRGRNS
S567 LNLEPFSSRPPGAME
T575 RPPGAMETEEERLVT
Y589 TIQKQLLYWELRREQ
S687 TSHRGTTSAFPATSS
S753 RKAYPSYSPPEEPEE
- gap
Y858 HKHAFNSYHSRFYQG
S872-p GLPWGVSsLPRYLGL
S899 ALNRRSRSLDNAESL
P1009 VAMPVSVPGRTPGDS
S1122 ASLSTSYSSTAMNGN
S1123 SLSTSYSSTAMNGNL
T1124 LSTSYSSTAMNGNLA
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