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ACTA2 (human)

Overview ACTA2 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Contractile protein; Motility/polarity/chemotaxis Cellular Component: protein complex; smooth muscle contractile fiber; cytoplasm; cytosol; actin cytoskeleton Molecular Function: ATP binding Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction Reference #:  P62736 (UniProtKB) Alt. Names/Synonyms: AAT6; ACTA; ACTA2; actin, alpha 2, smooth muscle, aorta; Actin, aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; Alpha-actin-2; alpha-cardiac actin; Cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46 Gene Symbols: ACTA2 Molecular weight: 42,009 Da Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ACTA2

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 102620 611788  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	88		S35-p	APRAVFPsIVGRPRH
0	59		K52-a	VMVGMGQkDsyVGDE
0	105		K52-u	VMVGMGQkDsyVGDE
0	404		S54-p	VGMGQkDsyVGDEAQ
0	991		Y55-p	GMGQkDsyVGDEAQs
0	9		S62-p	yVGDEAQskRGILtL
0	253		K63-a	VGDEAQskRGILtLk
0	110		K63-u	VGDEAQskRGILtLk
0	7		T68-p	QskRGILtLkyPIEH
0	7		K70-a	kRGILtLkyPIEHGI
0	4		K70-m1	kRGILtLkyPIEHGI
0	45		K70-u	kRGILtLkyPIEHGI
0	25		Y71-p	RGILtLkyPIEHGII
0	2		T79-p	PIEHGIItNWDDMEk
0	2		K86-a	tNWDDMEkIWHHSFy
0	2		K86-m1	tNWDDMEkIWHHSFy
0	81		Y93-p	kIWHHSFyNELrVAP
0	1		R97-m1	HSFyNELrVAPEEHP
0	1		K115-a	TEAPLNPkANREKMT
0	15		K115-u	TEAPLNPkANREKMT
0	16		Y145-p	IQAVLSLyASGRTTG
0	52		Y168-p	VTHNVPIyEGyALPH
0	61		Y171-p	NVPIyEGyALPHAIM
0	2		T188-p	DLAGRDLtDyLMkIL
0	208		Y190-p	AGRDLtDyLMkILtE
0	6		K193-a	DLtDyLMkILtERGy
0	87		K193-u	DLtDyLMkILtERGy
0	20		T196-p	DyLMkILtERGysFV
0	151		Y200-p	kILtERGysFVTTAE
0	5		S201-p	ILtERGysFVTTAER
0	3		T205	RGysFVTTAEREIVR
0	5		K215-a	REIVRDIkEkLCyVA
0	1		K217-a	IVRDIkEkLCyVALD
0	1		K217-m1	IVRDIkEkLCyVALD
0	1		K217	IVRDIkEKLCyVALD
0	12		Y220-p	DIkEkLCyVALDFEN
0	3		S235-p	EMATAASsSSLEksy
0	3		K240-u	ASsSSLEksyELPDG
0	10		S241-p	SsSSLEksyELPDGQ
0	24		Y242-p	sSSLEksyELPDGQV
0	14		T251-p	LPDGQVItIGNERFR
0	1		T262	ERFRCPETLFQPsFI
0	2		S267-p	PETLFQPsFIGMESA
0	14		Y281-p	AGIHETTyNSIMKCD
0	56		Y296-p	IDIRKDLyANNVLSG
0	54		Y308-p	LSGGTTMyPGIADRM
0	7		K317-a	GIADRMQkEItALAP
0	101		K317-u	GIADRMQkEItALAP
0	4		T320-p	DRMQkEItALAPstM
0	7		S325-p	EItALAPstMkIkII
0	5		T326-p	ItALAPstMkIkIIA
0	8		K328-a	ALAPstMkIkIIAPP
0	128		K328-u	ALAPstMkIkIIAPP
0	8		K330-a	APstMkIkIIAPPER
0	103		K330-u	APstMkIkIIAPPER
0	19		Y364-p	MWISKQEyDEAGPSI

	mouse
S35-p	APRAVFPsIVGRPRH
K52-a	VMVGMGQkDsyVGDE
K52-u	VMVGMGQkDsyVGDE
S54-p	VGMGQkDsyVGDEAQ
Y55-p	GMGQkDsyVGDEAQs
S62-p	yVGDEAQskRGILtL
K63-a	VGDEAQskRGILtLk
K63-u	VGDEAQskRGILtLk
T68-p	QskRGILtLkyPIEH
K70	kRGILtLKyPIEHGI
K70	kRGILtLKyPIEHGI
K70-u	kRGILtLkyPIEHGI
Y71-p	RGILtLkyPIEHGII
T79-p	PIEHGIItNWDDMEK
K86	tNWDDMEKIWHHSFY
K86	tNWDDMEKIWHHSFY
Y93	KIWHHSFYNELRVAP
R97	HSFYNELRVAPEEHP
K115	TEAPLNPKANREKMT
K115-u	TEAPLNPkANREKMT
Y145-p	IQAVLSLyASGRTTG
Y168-p	VTHNVPIyEGyALPH
Y171-p	NVPIyEGyALPHAIM
T188-p	DLAGRDLtDyLMkIL
Y190-p	AGRDLtDyLMkILtE
K193-a	DLtDyLMkILtERGy
K193-u	DLtDyLMkILtERGy
T196-p	DyLMkILtERGysFV
Y200-p	kILtERGysFVTtAE
S201-p	ILtERGysFVTtAER
T205-p	RGysFVTtAEREIVR
K215-a	REIVRDIkEkLCyVA
K217	IVRDIkEKLCyVALD
K217	IVRDIkEKLCyVALD
K217-u	IVRDIkEkLCyVALD
Y220-p	DIkEkLCyVALDFEN
S235-p	EMATAASsSSLEKsY
K240	ASsSSLEKsYELPDG
S241-p	SsSSLEKsYELPDGQ
Y242	sSSLEKsYELPDGQV
T251-p	LPDGQVItIGNERFR
T262-p	ERFRCPEtLFQPsFI
S267-p	PEtLFQPsFIGMESA
Y281-p	AGIHETTyNSIMKCD
Y296	IDIRKDLYANNVLSG
Y308	LSGGTTMYPGIADRM
K317-a	GIADRMQkEItALAP
K317-u	GIADRMQkEItALAP
T320-p	DRMQkEItALAPsTM
S325-p	EItALAPsTMkIkII
T326	ItALAPsTMkIkIIA
K328-a	ALAPsTMkIkIIAPP
K328-u	ALAPsTMkIkIIAPP
K330-a	APsTMkIkIIAPPER
K330-u	APsTMkIkIIAPPER
Y364-p	MWISKQEyDEAGPSI

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