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Protein Page:
SETD7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SETD7 Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43
Cellular Component: chromosome; nucleus
Molecular Function: protein binding; p53 binding; protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; chromatin modification
Reference #:  Q8WTS6 (UniProtKB)
Alt. Names/Synonyms: FLJ21193; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine N-methyltransferase 7; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7; SET7/9; SET9; SETD7
Gene Symbols: SETD7
Molecular weight: 40,721 Da
Basal Isoelectric point: 4.5  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SETD7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MDSDDEMVEE
0 1 K45 GNFVHGEKNGRGKFF
0 1 Y305-p SFTPNCIyDMFVHPR
0 1 K317 HPRFGPIKCIRTLRA
0 1 T332-p VEADEELtVAYGYDH
0 3 S340-p VAYGYDHsPPGKsGP
0 1 S345-p DHsPPGKsGPEAPEW
  mouse

 
S3-p _____MDsDDEVVEE
K45-ac GNFVHGEkNGRGKFF
Y305 SFTPNCVYDLFVHPR
K317-ub HPRFGPIkCIRTLRA
T332 VEAEEELTVAYGYDH
S340-p VAYGYDHsPPGKSGP
S345 DHsPPGKSGPEAPEW
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