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SETD7 (human)

Overview SETD7 Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily. Note: This description may include information from UniProtKB. Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase Cellular Component: chromosome; nucleus Molecular Function: protein binding; p53 binding; protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; chromatin modification Reference #:  Q8WTS6 (UniProtKB) Alt. Names/Synonyms: FLJ21193; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine N-methyltransferase 7; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7; SET7/9; SET9; SETD7 Gene Symbols: SETD7 Molecular weight: 40,721 Da Basal Isoelectric point: 4.5  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SETD7 1H3I - A/B=106-398 (human) 1MT6 - A=58-337 (human) 1MUF - A=81-337 (human) 1N6A - A=108-366 (human) 1N6C - A=70-366 (human) 1O9S - A/B=108-366 (human) 2F69 - A=110-366 (human) 3CBM - A=111-366 (human) 3CBO - A=111-366 (human) 3CBP - A=111-366 (human) 3M53 - A=110-366 (human) 3M54 - A=110-366 (human) 3M55 - A=110-366 (human) 3M56 - A=110-366 (human) 3M57 - A=110-366 (human) 3M58 - A=110-366 (human) 3M59 - A=110-366 (human) 3M5A - A=110-366 (human) 3OS5 - A=111-366 (human) 3VUZ - A=111-366 (human) 3VV0 - A=111-366 (human) 4E47 - A/D/C/B=109-366 (human) 4JDS - A/D/C/B=109-366 (human) 4JLG - A/B=109-366 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4JDS 4JLG  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3	_____MDSDDEMVEE
0	1		K45	GNFVHGEKNGRGKFF
0	1		Y305-p	SFTPNCIyDMFVHPR
0	1		K317	HPRFGPIKCIRTLRA
0	1		S340	VAYGYDHSPPGKSGP

	mouse
S3-p	_____MDsDDEVVEE
K45-a	GNFVHGEkNGRGKFF
Y305	SFTPNCVYDLFVHPR
K317-u	HPRFGPIkCIRTLRA
S340-p	VAYGYDHsPPGKSGP

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