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FLCN (human)

Overview FLCN May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Interacts (via C-terminus) with FNIP1 and FNIP2 (via C- terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. Belongs to the folliculin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function: protein binding Biological Process: regulation of protein amino acid phosphorylation Reference #:  Q8NFG4 (UniProtKB) Alt. Names/Synonyms: BHD; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; DKFZp547A118; FLCL; FLCN; FLJ45004; FLJ99377; Folliculin; MGC17998; MGC23445 Gene Symbols: FLCN Molecular weight: 64,473 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FLCN 3V42 - A/B=341-566 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  DISEASE 114500 135150 144700 173600 607273  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
2	20		S62-p	NSRMRAHsPAEGASV
0	7		S73-p	GASVESSsPGPKKSD
0	1		K206-u	ELQGKALkVFEAEQF
1	3		S302-p	ESESWDNsEAEEEEK
0	2		L313	EEEKAPVLPESTEGR
0	1		T393	SAFEVLRTMLPVGCV
0	1		S407	VRIIPYSSQYEEAYR
0	1		Y409	IIPYSSQYEEAYRCN
0	1		S537-p	EDTQKLLsILGAsEE
0	1		S542-p	LLsILGAsEEDNVKL
0	1		S558-p	KFWMTGLskTYKSHL
0	1		K559-u	FWMTGLskTYKSHLM

	FLCN iso2
S62	NSRMRAHSPAEGASV
S73	GASVESSSPGPKKSD
K206	ELQGKALKVFEAEQF
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S62-p	SSRVRAHsPAEGASS
S73-p	GASSESSsPGPKKSD
K206	ELQAKAFKVFEAEQF
S302-p	ESESWDNsEAEEEEK
T313-p	EEEKAPVtPEGAEGR
T393-p	SAFEVLRtMLPVGCV
S407-p	VRIIPYSsQyEEAYR
Y409-p	IIPYSsQyEEAYRCN
S537	EDTQKLLSVLGASEE
S542	LLSVLGASEEDNVKL
S558	KFWMTGLSKTYKSHL
K559	FWMTGLSKTYKSHLM

	rat
S62-p	SSRVRAHsPAEGAST
S73-p	GASTDSSsPGPKKSD
K206	ELQGKALKVFEAEQF
S302-p	ESESWDNsEAEEEEK
T313	EEEKAPATAEGAEGR
T393	SAFEVLRTMLPVGCV
S407	VRIIPYSSQYEEAYR
Y409	IIPYSSQYEEAYRCN
S537	EDTQKLLSVLGASEE
S542	LLSVLGASEEDNVKL
S558	KFWMTGLSKTYKSHL
K559	FWMTGLSKTYKSHLM

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