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Protein Page:
FLCN (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLCN a protein that is expressed in most tissues and that has no significant homology to other proteins. Involved in nutrient sensing through the AMPK and mTOR signaling pathways. Regulates lysosome function by promoting the mTORC1-dependent sequestration of transcription factor EB (TFEB). Required for the recruitment of mTORC1 to lysosomes by Rag GTPases. Amino acid depletion leads to its recruitment to the surface of lysosomes where it directly binds RagA, an interaction that is promoted by FNIP1. May be a tumor suppressor. Loss of function mutations cause Birt-Hogg-Dube syndrome (BHD), a disease characterized by fibrofolliculomas (hair follicle tumors), and predispositions for renal carcinoma, pneumothorax, and pulmonary cysts. These symptoms are similar to those that occur in TSC or tuberous sclerosis complex, suggesting the involvement in the same pathways as TSC1. Belongs to the folliculin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; plasma membrane; midbody; nucleus
Molecular Function: protein binding; protein complex binding
Biological Process: intercellular junction assembly; negative regulation of TOR signaling pathway; regulation of protein amino acid phosphorylation; TOR signaling pathway; positive regulation of cell adhesion; negative regulation of protein kinase B signaling cascade; positive regulation of apoptosis; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; regulation of cytokinesis; regulation of TOR signaling pathway; negative regulation of Rho protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; negative regulation of cell growth; positive regulation of protein amino acid phosphorylation; negative regulation of cell migration; positive regulation of TOR signaling pathway
Reference #:  Q8NFG4 (UniProtKB)
Alt. Names/Synonyms: BHD; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; DKFZp547A118; FLCL; FLCN; FLJ45004; FLJ99377; Folliculin; MGC17998; MGC23445
Gene Symbols: FLCN
Molecular weight: 64,473 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLCN

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
3 28 S62-p NSRMRAHsPAEGASV
1 9 S73-p GASVESSsPGPKKSD
0 1 K206-ub ELQGKALkVFEAEQF
0 1 T224-p QRAQRMNtAFTPFLH
1 6 S302-p ESESWDNsEAEEEEK
0 2 L313 EEEKAPVLPESTEGR
0 1 T393 SAFEVLRTMLPVGCV
0 1 S407 VRIIPYSSQYEEAYR
0 1 Y409 IIPYSSQYEEAYRCN
0 1 S537-p EDTQKLLsILGAsEE
0 1 S542-p LLsILGAsEEDNVKL
0 1 S558-p KFWMTGLskTYKSHL
0 1 K559-ub FWMTGLskTYKSHLM
0 1 S571-p HLMSTVRsPTASESR
  FLCN iso2  
S62 NSRMRAHSPAEGASV
S73 GASVESSSPGPKKSD
K206 ELQGKALKVFEAEQF
T224 QRAQRMNTAFTPFLH
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S62-p SSRVRAHsPAEGASS
S73-p GASSESSsPGPKKSD
K206 ELQAKAFKVFEAEQF
T224 QRAQRMNTAFTPFLH
S302-p ESESWDNsEAEEEEK
T313-p EEEKAPVtPEGAEGR
T393-p SAFEVLRtMLPVGCV
S407-p VRIIPYSsQyEEAYR
Y409-p IIPYSsQyEEAYRCN
S537 EDTQKLLSVLGASEE
S542 LLSVLGASEEDNVKL
S558 KFWMTGLSKTYKSHL
K559 FWMTGLSKTYKSHLM
S571 HLMSTVRSPTATESR
  rat

 
S62-p SSRVRAHsPAEGAST
S73-p GASTDSSsPGPKKSD
K206 ELQGKALKVFEAEQF
T224 QRAQRMNTAFTPFLH
S302-p ESESWDNsEAEEEEK
T313 EEEKAPATAEGAEGR
T393 SAFEVLRTMLPVGCV
S407 VRIIPYSSQYEEAYR
Y409 IIPYSSQYEEAYRCN
S537 EDTQKLLSVLGASEE
S542 LLSVLGASEEDNVKL
S558 KFWMTGLSKTYKSHL
K559 FWMTGLSKTYKSHLM
S571 HLMSTVRSPTAAESR
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