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HSPB8 (human)

Overview HSPB8 Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1. Interacts with DNAJB6. By 17-beta-estradiol. Predominantly expressed in skeletal muscle and heart. Belongs to the small heat shock protein (HSP20) family. Note: This description may include information from UniProtKB. Protein type: Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; ATYPICAL group; H11 family Cellular Component: cytoplasm; intracellular; nucleus Molecular Function: identical protein binding; protein binding; protein kinase activity Biological Process: cell death; response to stress Reference #:  Q9UJY1 (UniProtKB) Alt. Names/Synonyms: Alpha-crystallin C chain; CMT2L; CRYAC; DHMN2; E2-induced gene 1 protein; E2IG1; H11; heat shock 22kDa protein 8; heat shock 27kDa protein 8; Heat shock protein beta-8; HMN2; HMN2A; HSP22; HSPB8; Protein kinase H11; Small stress protein-like protein HSP22 Gene Symbols: HSPB8 Molecular weight: 21,604 Da Basal Isoelectric point: 5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HSPB8

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 158590 608014 608673  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
protein conformation: S24‑p, S27‑p, S57‑p, T87‑p protein degradation: S57‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S14-p	PFSCHYPsRLRRDPF
2	4		S24-p	RRDPFRDsPLsSRLL
2	0		S27-p	PFRDsPLsSRLLDDG
1	1		S57-p	DWALPRLsSAWPGtL
1	0		T63-p	LsSAWPGtLRSGMVP
0	1		R71	LRSGMVPRGPTATAR
0	1		R78	RGPTATARFGVPAEG
2	8		T87-p	GVPAEGRtPPPFPGE
0	1		S104-p	KVCVNVHsFKPEELM
0	2		Y118-p	MVKTKDGyVEVSGKH
0	1		K128	VSGKHEEKQQEGGIV

	mouse
S14	PFPCSYPSRLRRDPF
S24-p	RRDPFRDsPLSSRLL
S27	PFRDsPLSSRLLDDG
S57-p	EWALPRLsSAWPGTL
T63	LsSAWPGTLRSGMVP
R71	LRSGMVPRGPPATAR
R78	RGPPATARFGVPAEG
S87-p	GVPAEGRsPPPFPGE
S104	KVCVNVHSFKPEELM
Y118	MVKTKDGYVEVSGKH
K128-u	VSGKHEEkQQEGGIV

	rat
S14	PFPCSYPSRLRRDPF
S24	RRDPFRDSPLSSRLL
S27	PFRDSPLSSRLLDDG
S57	EWALPRLSSAWPGTL
T63	LSSAWPGTLRSGMVP
R71-m1	LRSGMVPrGPTATAr
R78-m1	rGPTATArFGVPAEG
N87	GVPAEGRNPPPFPGE
S104	KVCVNVHSFKPEELM
Y118	MVKTKDGYVEVSGKH
K128	VSGKHEEKQQEGGIV

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