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Protein Page:
RABGEF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RABGEF1 Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: recycling endosome; early endosome
Molecular Function: protein binding; DNA binding; zinc ion binding; Rab guanyl-nucleotide exchange factor activity
Biological Process: protein transport; endocytosis; positive regulation of Rab GTPase activity
Reference #:  Q9UJ41 (UniProtKB)
Alt. Names/Synonyms: FLJ32302; RAB guanine nucleotide exchange factor (GEF) 1; Rab5 GDP/GTP exchange factor; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RABEX5; RABGEF1; RABX5; RAP1
Gene Symbols: RABGEF1
Molecular weight: 79,371 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RABGEF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K142 SRKKMSLKSERRGIH
0 81 K263-ub AQSLTFSkFEEkkTN
0 19 K267-ub TFSkFEEkkTNEKTR
0 1 K268-ub FSkFEEkkTNEKTRK
0 1 K280-ub TRKVTTVkkFFsASS
0 21 K281-ub RKVTTVkkFFsASSR
0 4 S284-p TTVkkFFsASSRVGs
0 1 S291-p sASSRVGsKKEIQEA
0 7 K299-ub KKEIQEAkAPsPSIN
0 7 S302-p IQEAkAPsPSINRQt
0 3 S304 EAkAPsPSINRQtsI
0 4 T309-p sPSINRQtsIEtDRV
0 44 S310-p PSINRQtsIEtDRVS
0 2 T313-p NRQtsIEtDRVSkEF
0 4 K318-ub IEtDRVSkEFIEFLk
0 1 K325-ub kEFIEFLkTFHkTGQ
0 1 K329-ac EFLkTFHkTGQEIYK
0 3 K329-ub EFLkTFHkTGQEIYK
0 1 K339-ub QEIYKQTkLFLEGMH
0 1 K348-ac FLEGMHYkRDLSIEE
0 3 K348-ub FLEGMHYkRDLSIEE
0 1 K423 VPPERVEKIMDQIEk
0 1 K423-ub VPPERVEkIMDQIEk
0 1 K430-ac kIMDQIEkYIMTRLY
0 4 K520-ub KHIFNAIkITKNEPA
0 1 S562-p ITRFCNPsRLMTGED
0 3 S590-p IEKLDAQsLNLsQED
0 3 S594-p DAQsLNLsQEDFDRY
0 2 S603-p EDFDRYMsGQtsPRK
0 2 T606-p DRYMsGQtsPRKQEA
0 12 S607-p RYMsGQtsPRKQEAE
0 4 S617-p KQEAESWsPDACLGV
0 2 K629-ub LGVKQMYkNLDLLSQ
0 1 T659 EKDLIDWTDGIAREV
0 1 Y673-p VQDIVEKyPLEIKPP
  mouse

 
K4-ac ____MSLkSERRGIH
K85-ub AQSLTFSkFEEkKTN
K89-ub TFSkFEEkKTNEKTR
K90 FSkFEEkKTNEKTRK
K102 TRKVTTVKkFFSASS
K103-ub RKVTTVKkFFSASSR
S106 TTVKkFFSASSRAGS
S113 SASSRAGSKKEIQEA
K121 KKEIQEAKAPsPsIN
S124-p IQEAKAPsPsINRQt
S126-p EAKAPsPsINRQtsI
T131-p sPsINRQtsIEtDRV
S132-p PsINRQtsIEtDRVT
T135-p NRQtsIEtDRVTKEF
K140 IEtDRVTKEFIDFLK
K147 KEFIDFLKTFHKTGQ
K151 DFLKTFHKTGQEVYK
K151 DFLKTFHKTGQEVYK
K161 QEVYKQTKMFLEAMP
K170 FLEAMPYKRDLSIEE
K170-ub FLEAMPYkRDLSIEE
K206-ac VPPEKVEkIMDQIEK
K206 VPPEKVEKIMDQIEK
K213 kIMDQIEKHIMTRLY
K303-ub KHIFNAIkITKNEPA
S345 ITRFCNPSRLMTGED
S373-p IEKLDAQsLNLSQED
S377 DAQsLNLSQEDFDRY
S386 EDFDRYMSGQTsPRK
T389 DRYMSGQTsPRKQES
S390-p RYMSGQTsPRKQESE
P400 KQESESWPPEACLGV
K412 LGVKQMYKNLDLLSQ
T442-p EKDLIDWtDGIAKEV
Y456 VQDIVEKYPLEIKPP
  rat

 
K15 IRKKMSLKSERRGIH
K96 AQSLTFSKFEEKKTN
K100 TFSKFEEKKTNEKTR
K101 FSKFEEKKTNEKTRK
K113 TRKVTTVKKFFSASS
K114 RKVTTVKKFFSASSR
S117 TTVKKFFSASSRAGS
S124 SASSRAGSKKEIQEA
K132 KKEIQEAKAPSPSIN
S135 IQEAKAPSPSINRQT
S137 EAKAPSPSINRQTsI
T142 SPSINRQTsIETDRV
S143-p PSINRQTsIETDRVT
T146 NRQTsIETDRVTKEF
K151 IETDRVTKEFIDFLK
K158 KEFIDFLKTFHKTGQ
K162 DFLKTFHKTGQEVYK
K162 DFLKTFHKTGQEVYK
K172 QEVYKQTKMFLEAMP
K181 FLEAMPYKRDLSIEE
K181 FLEAMPYKRDLSIEE
K217 VPPEKVEKMMDQIEK
K217 VPPEKVEKMMDQIEK
K224 KMMDQIEKHIMTRLY
K314 KHIFNAIKITKNEPA
S356 ITRFCNPSRLMTGED
S384 IEKLDAQSLNLSQED
S388 DAQSLNLSQEDFDRY
S397 EDFDRYMSGQTsPRK
T400 DRYMSGQTsPRKQES
S401-p RYMSGQTsPRKQESE
S411 KQESESWSPEACLGV
K423 LGVKQMYKNLDLLSQ
T453 EKDLIDWTDGIAKEV
Y467 VQDIVEKYPLEIKPP
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