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Protein Page:
BRD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRD2 an atypical protein kinase with two bromodomains that bind to acetylated lysine residues. Specifically interacts with transcriptionally active chromatin. Elevated protein kinase activity in leukemias. Transgenic mice overexpressing BRD2 in the lymphoid system develop diffuse large-cell lymphoma. Interacts with E2F1 and with histone H4 acetylated at Lys-13. May play a role in spermatogenesis or folliculogenesis. Genetic evidence links the BRD2 gene to both juvenile myoclonic epilepsy and photoparoxysomal responses. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; ATYPICAL group; BRD family
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; chromatin binding
Biological Process: regulation of transcription from RNA polymerase II promoter; nucleosome assembly; transcription, DNA-dependent; spermatogenesis; chromatin modification
Reference #:  P25440 (UniProtKB)
Alt. Names/Synonyms: BRD2; bromodomain containing 2; bromodomain-containing 2; Bromodomain-containing protein 2; D6S113E; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; FSRG1; KIAA9001; NAT; O27.1.1; Really interesting new gene 3 protein; RING3; RNF3
Gene Symbols: BRD2
Molecular weight: 88,061 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T6-p __MLQNVtPHNkLPG
0 51 K10-ac QNVtPHNkLPGEGNA
0 53 K31-ac PEAAAPGkRIRKPsL
0 338 S37-p GkRIRKPsLLyEGFE
0 8 Y40-p IRKPsLLyEGFEsPt
0 7 S45-p LLyEGFEsPtMAsVP
0 1 T47-p yEGFEsPtMAsVPAL
0 4 S50-p FEsPtMAsVPALQLt
0 1 T57-p sVPALQLtPANPPPP
0 1 T125-p KQPMDMGtIKRRLEN
0 1 Y134 KRRLENNYYWAASEC
0 1 Y135 RRLENNYYWAASECM
0 1 S139 NNYYWAASECMQDFN
0 1 T159 CYIYNKPTDDIVLMA
0 1 T168 DIVLMAQTLEKIFLQ
0 1 S248-p PHPSVISsPLLKsLH
0 1 S253-p ISsPLLKsLHSAGPP
0 1 T285-p GVKRKADtTTPTPtA
0 1 T291-p DtTTPTPtAILAPGs
0 87 S298-p tAILAPGsPAsPPGs
0 80 S301-p LAPGsPAsPPGsLEP
0 27 S305-p sPAsPPGsLEPKAAR
0 2 S320-p LPPMRREsGRPIKPP
0 3 S334-p PRKDLPDsQQQHQsS
0 2 S340-p DsQQQHQsSkKGKLS
0 1 S341 sQQQHQsSkKGKLSE
0 9 K342-ac QQQHQsSkKGKLSEQ
0 1 S362 GILKELLSKKHAAYA
0 3 Y450-p QDVFEFRyAKMPDEP
0 7 S538-p HEQLAALsQGPISKP
0 1 S608-p GPSGFGPsGGsGTkL
0 1 S611-p GFGPsGGsGTkLPkK
0 1 K614-ac PsGGsGTkLPkKATK
0 2 K617-ac GsGTkLPkKATKTAP
0 1 T629-p TAPPALPtGyDsEEE
0 2 Y631-p PPALPtGyDsEEEEE
0 13 S633-p ALPtGyDsEEEEESR
0 1 S651-p YDEKRQLsLDINKLP
0 1 T690-p EIEIDFEtLKPSTLR
0 1 S705-p ELERYVLsCLRKKPR
0 1 Y715-p RKKPRKPytIKKPVG
0 1 T716-p KKPRKPytIKKPVGK
0 1 T724-p IKKPVGKtKEELALE
0 2 S744-p EKRLQDVsGQLNsTK
0 1 S749-p DVsGQLNsTKKPPKK
0 1 S775-p QVAVSRLsAsssSSD
0 1 S777-p AVSRLsAsssSSDSs
0 2 S778-p VSRLsAsssSSDSsS
0 1 S779-p SRLsAsssSSDSsSS
0 1 S784-p sssSSDSsSSSSsSS
0 3 S789-p DSsSSSSsSSSSDtS
0 1 S791 sSSSSsSSSSDtSDS
0 1 S792 SSSSsSSSSDtSDSD
0 1 S793 SSSsSSSSDtSDSDS
0 1 T795-p SsSSSSDtSDSDSG_
0 1 S800 SDtSDSDSG______
  BRD2 iso2  
T6 __MLQNVTPHNKLPG
K10 QNVTPHNKLPGEGNA
K31 PEAAAPGKRIRKPSL
S37 GKRIRKPSLLYEGFE
Y40 IRKPSLLYEGFESPT
S45 LLYEGFESPTMASVP
T47 YEGFESPTMASVPAL
S50 FESPTMASVPALQLT
T57 SVPALQLTPANPPPP
T125 KQPMDMGTIKRRLEN
Y134 KRRLENNYYWAASEC
Y135 RRLENNYYWAASECM
S139 NNYYWAASECMQDFN
T159 CYIYNKPTDDIVLMA
T168 DIVLMAQTLEKIFLQ
S248 PHPSVISSPLLKSLH
S253 ISSPLLKSLHSAGPP
T285 GVKRKADTTTPTPTA
T291 DTTTPTPTAILAPGS
S298 TAILAPGSPASPPGS
S301 LAPGSPASPPGSLEP
S305 SPASPPGSLEPKAAR
S320 LPPMRRESGRPIKPP
S334 PRKDLPDSQQQHQSS
S340 DSQQQHQSSKKGKLS
S341 SQQQHQSSKKGKLSE
K342 QQQHQSSKKGKLSEQ
S362 GILKELLSKKHAAYA
Y450 QDVFEFRYAKMPDEP
S538 HEQLAALSQGPISKP
S608 GPSGFGPSGGSGTKL
S611 GFGPSGGSGTKLQAG
K614 PSGGSGTKLQAGVQW
K652 SQDYRLPKKATKTAP
T664 TAPPALPTGYDSEEE
Y666 PPALPTGYDSEEEEE
S668 ALPTGYDSEEEEESR
S686 YDEKRQLSLDINKLP
T725 EIEIDFETLKPSTLR
S740 ELERYVLSCLRKKPR
Y750 RKKPRKPYTIKKPVG
T751 KKPRKPYTIKKPVGK
T759 IKKPVGKTKEELALE
S779 EKRLQDVSGQLNSTK
S784 DVSGQLNSTKKPPKK
S810 QVAVSRLSASSSSSD
S812 AVSRLSASSSSSDSS
S813 VSRLSASSSSSDSSS
S814 SRLSASSSSSDSSSS
S819 SSSSSDSSSSSSSSS
S824 DSSSSSSSSSSSDTS
S826 SSSSSSSSSSDTSDS
S827 SSSSSSSSSDTSDSD
S828 SSSSSSSSDTSDSDS
T830 SSSSSSDTSDSDSG_
S835 SDTSDSDSG______
  mouse

 
T6 __MLQNVTPHkLPGE
K9-ac LQNVTPHkLPGEGNA
K30-ac PEAAAPGkRIRKPsL
S36-p GkRIRKPsLLYEGFE
Y39 IRKPsLLYEGFESPt
S44 LLYEGFESPtMASVP
T46-p YEGFESPtMASVPAL
S49 FESPtMASVPALQLA
A56 SVPALQLAPANPPPP
T124 KQPMDMGTIKRRLEN
Y133-p KRRLENNyyWAAsEC
Y134-p RRLENNyyWAAsECM
S138-p NNyyWAAsECMQDFN
T158-p CYIYNKPtDDIVLMA
T167-p DIVLMAQtLEKIFLQ
S247 PHPSVISSPLLKSLH
S252 ISSPLLKSLHSAGPP
T284-p GVKRKADtTTPTPTA
T290 DtTTPTPTAILAPGs
S297-p TAILAPGsPAsPPGs
S300-p LAPGsPAsPPGsLEP
S304-p sPAsPPGsLEPKAAR
S319 LPPMRRESGRPIKPP
S333-p PRKDLPDsQQQHQss
S339-p DsQQQHQssKKGKLS
S340-p sQQQHQssKKGKLSE
K341 QQQHQssKKGKLSEQ
S361-p GILKELLsKKHAAYA
Y449 QDVFEFRYAKMPDEP
S536 HEQLAALSQGPISKP
S606 SHPGFGTSGGSSNKL
S609 GFGTSGGSSNKLPKK
K612 TSGGSSNKLPKKSQK
K615 GSSNKLPKKSQKTAP
T627 TAPPVLPTGYDsEEE
Y629 PPVLPTGYDsEEEEE
S631-p VLPTGYDsEEEEESR
S649 YDEKRQLSLDINKLP
T688 EIEIDFETLKPSTLR
S703 ELERYVLSCLRKKPR
Y713 RKKPRKPYTIRKPVG
T714 KKPRKPYTIRKPVGK
T722 IRKPVGKTKEELALE
S742 EKRLQDVSGQLNSTK
S747 DVSGQLNSTKKPPKK
S772 QVAVSRLSASsSSSD
S774 AVSRLSASsSSSDSS
S775-p VSRLSASsSSSDSSS
S776 SRLSASsSSSDSSSS
S781 SsSSSDSSSSSSsSs
S786-p DSSSSSSsSsssDTS
S788-p SSSSSsSsssDTSDS
S789-p SSSSsSsssDTSDSD
S790-p SSSsSsssDTSDSDs
T792 SsSsssDTSDSDsG_
S797-p sDTSDSDsG______
  rat

 
T6 __MLQNVTPHKLPGE
K9 LQNVTPHKLPGEGNA
K30-ac PEAAAPGkRIRKPsL
S36-p GkRIRKPsLLYEGFE
Y39 IRKPsLLYEGFESPT
S44 LLYEGFESPTMASVP
T46 YEGFESPTMASVPAL
S49 FESPTMASVPALQLA
A56 SVPALQLAPANPPPP
T124 KQPMDMGTIKRRLEN
Y133 KRRLENNYYWAASEC
Y134 RRLENNYYWAASECM
S138 NNYYWAASECMQDFN
T158 CYIYNKPTDDIVLMA
T167 DIVLMAQTLEKIFLQ
S247 PHPSVISSPLLKSLH
S252 ISSPLLKSLHSAGPP
T284 GVKRKADTTTPTPTA
T290 DTTTPTPTAILAPGs
S297-p TAILAPGsPAsPPGs
S300-p LAPGsPAsPPGsLEP
S304-p sPAsPPGsLEPKAAR
S319 LPPMRRESGRPIKPP
S333 PRKDLPDSQQQHQSS
S339 DSQQQHQSSKKGKLS
S340 SQQQHQSSKKGKLSE
K341 QQQHQSSKKGKLSEQ
S361 GILKELLSKKHAAYA
Y449 QDVFEFRYAKMPDEP
S536 HEQLAALSQGPISKP
S606 SHPGFGTSAGSSNKL
S609 GFGTSAGSSNKLPKK
K612 TSAGSSNKLPKKAQK
K615 GSSNKLPKKAQKTAP
T627 TAPPVLPTGYDsEEE
Y629 PPVLPTGYDsEEEEE
S631-p VLPTGYDsEEEEESR
S649 YDEKRQLSLDINKLP
T688 EIEIDFETLKPSTLR
S703 ELERYVLSCLRKKPR
Y713 RKKPRKPYTIRKPVG
T714 KKPRKPYTIRKPVGK
T722 IRKPVGKTKEELALE
S742 EKRLQDVSGQLNSTK
S747 DVSGQLNSTKKPPKK
S772 QVAVSRLSASSSSSD
S774 AVSRLSASSSSSDSS
S775 VSRLSASSSSSDSSS
S776 SRLSASSSSSDSSSS
S781 SSSSSDSSSSSSSSS
S786 DSSSSSSSSSSSDTS
S788 SSSSSSSSSSDTSDS
S789 SSSSSSSSSDTSDSD
S790 SSSSSSSSDTSDSDS
T792 SSSSSSDTSDSDSG_
S797 SDTSDSDSG______
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