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Protein Page:
BRD2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BRD2 an atypical protein kinase with two bromodomains that bind to acetylated lysine residues. Specifically interacts with transcriptionally active chromatin. Elevated protein kinase activity in leukemias. Transgenic mice overexpressing BRD2 in the lymphoid system develop diffuse large-cell lymphoma. Interacts with E2F1 and with histone H4 acetylated at Lys-13. May play a role in spermatogenesis or folliculogenesis. Genetic evidence links the BRD2 gene to both juvenile myoclonic epilepsy and photoparoxysomal responses. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, atypical; ATYPICAL group; BRD family
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; chromatin binding
Biological Process: regulation of transcription from RNA polymerase II promoter; nucleosome assembly; transcription, DNA-dependent; spermatogenesis; chromatin modification
Reference #:  P25440 (UniProtKB)
Alt. Names/Synonyms: BRD2; bromodomain containing 2; bromodomain-containing 2; Bromodomain-containing protein 2; D6S113E; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; FSRG1; KIAA9001; NAT; O27.1.1; Really interesting new gene 3 protein; RING3; RNF3
Gene Symbols: BRD2
Molecular weight: 88,061 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MLQNVtPHNkLPG
0 51 K10-a QNVtPHNkLPGEGNA
0 52 K31-a PEAAAPGkRIRKPsL
0 309 S37-p GkRIRKPsLLyEGFE
0 7 Y40-p IRKPsLLyEGFEsPt
0 6 S45-p LLyEGFEsPtMAsVP
0 1 T47-p yEGFEsPtMAsVPAL
0 3 S50-p FEsPtMAsVPALQLt
0 1 T57-p sVPALQLtPANPPPP
0 1 Y134 KRRLENNYYWAASEC
0 1 Y135 RRLENNYYWAASECM
0 1 S139 NNYYWAASECMQDFN
0 1 T159 CYIYNKPTDDIVLMA
0 1 T168 DIVLMAQTLEKIFLQ
0 1 S253-p ISSPLLKsLHSAGPP
0 75 S298-p TAILAPGsPAsPPGs
0 68 S301-p LAPGsPAsPPGsLEP
0 21 S305-p sPAsPPGsLEPKAAR
0 2 S320-p LPPMRREsGRPIKPP
0 1 S334 PRKDLPDSQQQHQSS
0 1 S340 DSQQQHQSSkKGKLS
0 1 S341 SQQQHQSSkKGKLSE
0 9 K342-a QQQHQSSkKGKLSEQ
0 1 S362 GILKELLSKKHAAYA
0 3 Y450-p QDVFEFRyAKMPDEP
0 5 S538-p HEQLAALsQGPISKP
0 2 K617-a GSGTKLPkKATKTAP
0 1 T629-p TAPPALPtGyDsEEE
0 1 Y631-p PPALPtGyDsEEEEE
0 10 S633-p ALPtGyDsEEEEESR
0 1 T690-p EIEIDFEtLKPSTLR
0 1 T724-p IKKPVGKtKEELALE
0 2 S789-p DSSSSSSsSSSSDTS
  mouse

 
T6 __MLQNVTPHkLPGE
K9-a LQNVTPHkLPGEGNA
K30-a PEAAAPGkRIRKPsL
S36-p GkRIRKPsLLYEGFE
Y39 IRKPsLLYEGFESPt
S44 LLYEGFESPtMASVP
T46-p YEGFESPtMASVPAL
S49 FESPtMASVPALQLA
A56 SVPALQLAPANPPPP
Y133-p KRRLENNyyWAAsEC
Y134-p RRLENNyyWAAsECM
S138-p NNyyWAAsECMQDFN
T158-p CYIYNKPtDDIVLMA
T167-p DIVLMAQtLEKIFLQ
S252 ISSPLLKSLHSAGPP
S297-p TAILAPGsPAsPPGs
S300-p LAPGsPAsPPGsLEP
S304-p sPAsPPGsLEPKAAR
S319 LPPMRRESGRPIKPP
S333-p PRKDLPDsQQQHQss
S339-p DsQQQHQssKKGKLS
S340-p sQQQHQssKKGKLSE
K341 QQQHQssKKGKLSEQ
S361-p GILKELLsKKHAAYA
Y449 QDVFEFRYAKMPDEP
S536 HEQLAALSQGPISKP
K615 GSSNKLPKKSQKTAP
T627 TAPPVLPTGYDsEEE
Y629 PPVLPTGYDsEEEEE
S631-p VLPTGYDsEEEEESR
T688 EIEIDFETLKPSTLR
T722 IRKPVGKTKEELALE
S786-p DSSSSSSsSSSSDTS
  rat

 
T6 __MLQNVTPHKLPGE
K9 LQNVTPHKLPGEGNA
K30 PEAAAPGKRIRKPsL
S36-p GKRIRKPsLLYEGFE
Y39 IRKPsLLYEGFESPT
S44 LLYEGFESPTMASVP
T46 YEGFESPTMASVPAL
S49 FESPTMASVPALQLA
A56 SVPALQLAPANPPPP
Y133 KRRLENNYYWAASEC
Y134 RRLENNYYWAASECM
S138 NNYYWAASECMQDFN
T158 CYIYNKPTDDIVLMA
T167 DIVLMAQTLEKIFLQ
S252 ISSPLLKSLHSAGPP
S297-p TAILAPGsPAsPPGs
S300-p LAPGsPAsPPGsLEP
S304-p sPAsPPGsLEPKAAR
S319 LPPMRRESGRPIKPP
S333 PRKDLPDSQQQHQSS
S339 DSQQQHQSSKKGKLS
S340 SQQQHQSSKKGKLSE
K341 QQQHQSSKKGKLSEQ
S361 GILKELLSKKHAAYA
Y449 QDVFEFRYAKMPDEP
S536 HEQLAALSQGPISKP
K615 GSSNKLPKKAQKTAP
T627 TAPPVLPTGYDSEEE
Y629 PPVLPTGYDSEEEEE
S631 VLPTGYDSEEEEESR
T688 EIEIDFETLKPSTLR
T722 IRKPVGKTKEELALE
S786 DSSSSSSSSSSSDTS
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