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BRD2 (human)

Overview BRD2 an atypical protein kinase with two bromodomains that bind to acetylated lysine residues. Specifically interacts with transcriptionally active chromatin. Elevated protein kinase activity in leukemias. Transgenic mice overexpressing BRD2 in the lymphoid system develop diffuse large-cell lymphoma. Interacts with E2F1 and with histone H4 acetylated at Lys-13. May play a role in spermatogenesis or folliculogenesis. Genetic evidence links the BRD2 gene to both juvenile myoclonic epilepsy and photoparoxysomal responses. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BRD family Cellular Component: cytoplasm; nucleus Molecular Function: chromatin binding Biological Process: regulation of transcription from RNA polymerase II promoter; nucleosome assembly; transcription, DNA-dependent; spermatogenesis; chromatin modification Reference #:  P25440 (UniProtKB) Alt. Names/Synonyms: BRD2; bromodomain containing 2; bromodomain-containing 2; Bromodomain-containing protein 2; D6S113E; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; FSRG1; KIAA9001; NAT; O27.1.1; Really interesting new gene 3 protein; RING3; RNF3 Gene Symbols: BRD2 Molecular weight: 88,061 Da Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BRD2 1X0J - A/B/C=73-194 (human) 2DVQ - A/B/C=73-194 (human) 2DVR - A/B/C=73-194 (human) 2DVS - A/B/C=73-194 (human) 2DVV - A=344-455 (human) 2E3K - A/D/C/B=348-455 (human) 2G4A - A=348-455 (human) 2YDW - A/C/B=67-200 (human) 2YEK - A/C/B=67-200 (human) 3AQA - A/C/B=73-194 (human) 4A9E - A/C/B=67-200 (human) 4A9F - A/C/B=67-200 (human) 4A9H - A/C/B=67-200 (human) 4A9I - A/C/B=67-200 (human) 4A9J - A/C/B=67-200 (human) 4A9M - A/C/B=67-200 (human) 4A9N - A/C/B=67-200 (human) 4A9O - A/C/B=67-200 (human) 4A9P - A/C/B=67-200 (human) 4AKN - A/C/B=67-200 (human) 4ALG - A=67-200 (human) 4ALH - A/C/B=67-200 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4A9P 4AKN 4ALG 4ALH  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T6-p	__MLQNVtPHNkLPG
0	51		K10-a	QNVtPHNkLPGEGNA
0	52		K31-a	PEAAAPGkRIRKPsL
0	309		S37-p	GkRIRKPsLLyEGFE
0	7		Y40-p	IRKPsLLyEGFEsPt
0	6		S45-p	LLyEGFEsPtMAsVP
0	1		T47-p	yEGFEsPtMAsVPAL
0	3		S50-p	FEsPtMAsVPALQLt
0	1		T57-p	sVPALQLtPANPPPP
0	1		T125-p	KQPMDMGtIKRRLEN
0	1		S248-p	PHPSVISsPLLKsLH
0	1		S253-p	ISsPLLKsLHSAGPP
0	71		S298-p	TAILAPGsPAsPPGs
0	64		S301-p	LAPGsPAsPPGsLEP
0	21		S305-p	sPAsPPGsLEPKAAR
0	2		S320-p	LPPMRREsGRPIKPP
0	1		S334	PRKDLPDSQQQHQSS
0	1		S340	DSQQQHQSSkKGKLS
0	1		S341	SQQQHQSSkKGKLSE
0	9		K342-a	QQQHQSSkKGKLSEQ
0	1		S362	GILKELLSKKHAAYA
0	3		Y450-p	QDVFEFRyAKMPDEP
0	4		S538-p	HEQLAALsQGPISKP
0	1		K614-a	PSGGSGTkLPkKATK
0	2		K617-a	GSGTkLPkKATKTAP
0	1		Y631-p	PPALPTGyDsEEEEE
0	8		S633-p	ALPTGyDsEEEEESR
0	1		T690-p	EIEIDFEtLKPSTLR
0	1		T724-p	IKKPVGKtKEELALE
0	1		S775-p	QVAVSRLsASSSSSD
0	1		S778	VSRLsASSSSSDSsS
0	1		S784-p	SSSSSDSsSSSSsSS
0	2		S789-p	DSsSSSSsSSSSDtS
0	1		S791	sSSSSsSSSSDtSDS
0	1		S792	SSSSsSSSSDtSDSD
0	1		S793	SSSsSSSSDtSDSDS
0	1		T795-p	SsSSSSDtSDSDSG_
0	1		S800	SDtSDSDSG______

	mouse
T6	__MLQNVTPHkLPGE
K9-a	LQNVTPHkLPGEGNA
K30-a	PEAAAPGkRIRKPsL
S36-p	GkRIRKPsLLYEGFE
Y39	IRKPsLLYEGFESPt
S44	LLYEGFESPtMASVP
T46-p	YEGFESPtMASVPAL
S49	FESPtMASVPALQLA
A56	SVPALQLAPANPPPP
T124	KQPMDMGTIKRRLEN
S247	PHPSVISSPLLKSLH
S252	ISSPLLKSLHSAGPP
S297-p	TAILAPGsPAsPPGs
S300-p	LAPGsPAsPPGsLEP
S304-p	sPAsPPGsLEPKAAR
S319	LPPMRRESGRPIKPP
S333-p	PRKDLPDsQQQHQss
S339-p	DsQQQHQssKKGKLS
S340-p	sQQQHQssKKGKLSE
K341	QQQHQssKKGKLSEQ
S361-p	GILKELLsKKHAAYA
Y449	QDVFEFRYAKMPDEP
S536	HEQLAALSQGPISKP
K612	TSGGSSNKLPKKSQK
K615	GSSNKLPKKSQKTAP
Y629	PPVLPTGYDsEEEEE
S631-p	VLPTGYDsEEEEESR
T688	EIEIDFETLKPSTLR
T722	IRKPVGKTKEELALE
S772	QVAVSRLSASsSSSD
S775-p	VSRLSASsSSSDSSS
S781	SsSSSDSSSSSSsSs
S786-p	DSSSSSSsSsssDTS
S788-p	SSSSSsSsssDTSDS
S789-p	SSSSsSsssDTSDSD
S790-p	SSSsSsssDTSDSDs
T792	SsSsssDTSDSDsG_
S797-p	sDTSDSDsG______

	rat
T6	__MLQNVTPHKLPGE
K9	LQNVTPHKLPGEGNA
K30	PEAAAPGKRIRKPsL
S36-p	GKRIRKPsLLYEGFE
Y39	IRKPsLLYEGFESPT
S44	LLYEGFESPTMASVP
T46	YEGFESPTMASVPAL
S49	FESPTMASVPALQLA
A56	SVPALQLAPANPPPP
T124	KQPMDMGTIKRRLEN
S247	PHPSVISSPLLKSLH
S252	ISSPLLKSLHSAGPP
S297-p	TAILAPGsPAsPPGs
S300-p	LAPGsPAsPPGsLEP
S304-p	sPAsPPGsLEPKAAR
S319	LPPMRRESGRPIKPP
S333	PRKDLPDSQQQHQSS
S339	DSQQQHQSSKKGKLS
S340	SQQQHQSSKKGKLSE
K341	QQQHQSSKKGKLSEQ
S361	GILKELLSKKHAAYA
Y449	QDVFEFRYAKMPDEP
S536	HEQLAALSQGPISKP
K612	TSAGSSNKLPKKAQK
K615	GSSNKLPKKAQKTAP
Y629	PPVLPTGYDSEEEEE
S631	VLPTGYDSEEEEESR
T688	EIEIDFETLKPSTLR
T722	IRKPVGKTKEELALE
S772	QVAVSRLSASSSSSD
S775	VSRLSASSSSSDSSS
S781	SSSSSDSSSSSSSSS
S786	DSSSSSSSSSSSDTS
S788	SSSSSSSSSSDTSDS
S789	SSSSSSSSSDTSDSD
S790	SSSSSSSSDTSDSDS
T792	SSSSSSDTSDSDSG_
S797	SDTSDSDSG______

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