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Protein Page:
MUTYH (human)

Overview
MUTYH Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Hydrolase; DNA repair, damage; EC 3.2.2.-
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; metal ion binding; 4 iron, 4 sulfur cluster binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutLbeta complex binding; MutSbeta complex binding; MutSalpha complex binding
Biological Process: mismatch repair; depurination; base-excision repair, AP site formation; base-excision repair; DNA repair
Reference #:  Q9UIF7 (UniProtKB)
Alt. Names/Synonyms: A/G-specific adenine DNA glycosylase; CYP2C; hMYH; MGC4416; MutY homolog; mutY homolog (E. coli); MUTYH; MYH
Gene Symbols: MUTYH
Molecular weight: 60,069 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MUTYH

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S535‑p
protein stabilization: S535‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MTPLVsRLsRLWA
0 1 S9-p TPLVsRLsRLWAIMR
0 1 S24-p KPRAAVGsGHRKQAA
0 1 S360-p VNFPRKAsRKPPREE
0 3 Y494-p MKKVFRVyQGQQPGT
0 1 S505-p QPGTCMGsKRSQVSs
0 3 S512-p sKRSQVSsPCSRKKP
1 1 S535-p NFFRSHIsTDAHSLN
  mouse

 
S7 _MKKLQASVRSHKKQ
S10 KLQASVRSHKKQPAN
- under review  
S331 ANFPRKASRRPPREE
Y465 MKKVFRMYEDHRQGT
S476 RQGTRKGSKRSQVCP
P483 SKRSQVCPPSSRKKP
P506 TFFQRHIPTDKPNST
  rat

 
S7 _MKKLRASVRSHKKQ
S10 KLRASVRSHKKQPAN
- under review  
S331 VNFPRKASRRPPREE
Y466 MKKVFRVYEEHRRGT
S477 RRGTCKGSKRPQVCT
T484 SKRPQVCTPSSRKKP
P507 RFFQRHIPTHKPNST
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