Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; DNA repair, damage; Mitochondrial; EC 3.2.2.-
Cellular Component: nucleoplasm; mitochondrion
Molecular Function: protein binding; metal ion binding; 4 iron, 4 sulfur cluster binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutSbeta complex binding; MutLbeta complex binding; MutSalpha complex binding
Biological Process: mismatch repair; depurination; base-excision repair, AP site formation; base-excision repair; DNA repair
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.