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Protein Page:
SMARCAL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCAL1 ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.-; Helicase; EC 3.6.1.-
Cellular Component: DNA replication factor A complex; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; helicase activity; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; ATP catabolic process; DNA strand renaturation; chromatin modification; DNA metabolic process; response to DNA damage stimulus; replication fork processing
Reference #:  Q9NZC9 (UniProtKB)
Alt. Names/Synonyms: ATP-driven annealing helicase; HARP; HepA-related protein; hHARP; SMAL1; SMARCA-like protein 1; SMARCAL1; Sucrose nonfermenting protein 2-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Gene Symbols: SMARCAL1
Molecular weight: 105,938 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Select Structure to View Below

SMARCAL1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S889‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S89 ADQRPHDSHSFQAKG
0 1 - gap
0 1 - gap
0 8 S112-p PTACPGHsPRSQMAL
0 1 T120-p PRSQMALtGIsPPLA
0 4 S123-p QMALtGIsPPLAQsP
0 5 S129-p IsPPLAQsPPEVPKQ
0 4 S151-p GQGHAQAsPEIRFTP
0 2 S172-p KPLAKPKssQETPAH
0 1 S173-p PLAKPKssQETPAHS
0 1 S181-p QETPAHSsGQPPRDA
0 3 S198-p EAKTAKAsPSGQNIS
0 1 S211-p ISYIHSSsESVtPRT
0 5 T215-p HSSsESVtPRTEGRL
0 1 T274 SKNYDPDTKTWNFSM
0 1 Y306-p LQPLEWAyGSSESPS
0 1 Y365 KQMDSRRYDVKTRKW
0 1 K450-ub GVNFAIAkGGRLLLA
0 1 S528-p AGLINIVsFDLLsKL
0 1 S533-p IVsFDLLsKLEKQLK
0 1 T559 HFLKNSRTARCRAAM
0 1 S627-p WGWDYSGsSNLGELK
0 1 S648 VMLRRLKSDVLsQLP
1 2 S652-p RLKSDVLsQLPAKQR
0 1 K682 AALDAAAKEMTTKDK
0 1 K687 AAKEMTTKDKTKQQQ
0 1 Y872-p EMTESTDyLyKDPKQ
0 1 Y874-p TESTDyLyKDPKQQK
1 2 S889-p IYDLFQKsFEKEGSD
0 1 S934-p DESSLTAsPQKKRRF
0 3 S952-p DNWDSFTsPL_____
  mouse

► Hide Isoforms
 
S87 TDQRPHSSRCSQPSP
S93 SSRCSQPSPAEETTG
- gap
- gap
S109 WKTQGEMSTACPKPN
- gap
S118-p ACPKPNPsPPGASNQ
T140 SEGQPQATWDTGASS
- gap
- gap
S148 WDTGASSSGPFPRDP
S165 EAKAARPSTSRQSIS
- gap
T182 FYVLGGKTPRTEGRP
T240 SRHYDSFTKTWDFSM
- gap
Y324 KQMESRSYDIKTRKW
K409 GVSFAISKRGRLLLA
S487 AGLVNIVSFDLLCKL
C492 IVSFDLLCKLERQLK
T518-p HFLKNIKtARCRAAV
S586 WGWDYSGSSNLGELK
S607-p IMLRRLKsDVLSQLP
S611 RLKsDVLSQLPAKQR
K641 AALDAAAKEMTKDKT
K645 AAAKEMTKDKTKQQQ
Y830 EMTEATDYVHKDPKQ
H832 TEATDYVHKDPKQKT
S847 IYDLFQQSFEDDGND
S890 LLDEDEGSPPKKSRF
S908 DNWDSFSSPF_____
  SMARCAL1 iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T78-p QQNLNSFtKTWDFSM
- gap
Y162 KQMESRSYDIKTRKW
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
  rat

 
S88-p AAQRPHSsPCFQPst
S94-p SsPCFQPstAEEAKG
T95-p sPCFQPstAEEAKGL
- gap
S110 WKSEGKMSAACPNPS
- gap
S117 SAACPNPSPPEVSNQ
T139 SEGHPQATQDTAASC
- gap
- gap
- gap
S164 EAKAGRPSTSGQSIS
- gap
T181 FYALGEKTPKTDGRP
T239 SRRYDSFTKTWDFSM
- gap
Y322-p KQMESRNyDPKTRKW
K407 GVSFAISKRGRLLLA
S485 AGLVNIVSFDLLSKL
S490 IVSFDLLSKLEKQLK
T516 HFLKNIKTARCRAAV
S584 WGWDYSGSSNLGELK
S605 VMLRRLKSDVLSQLP
S609 RLKSDVLSQLPAKQR
K639-ub AALDAAAkEMTkDKT
K643-ub AAAkEMTkDKTKQQQ
Y828 EMTEATDYLYKDPKQ
Y830 TEATDYLYKDPKQKT
S845 IYSLFQQSFEDDGND
S890 DENALADSPPKKRRF
S908 DNWDSFTSPF_____
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