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Protein Page:
TCF7L2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TCF7L2 Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Interacts with TGFB1I1. Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. Belongs to the TCF/LEF family. 10 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Cell development/differentiation; Motility/polarity/chemotaxis; DNA binding protein; Cell cycle regulation; Apoptosis
Cellular Component: nucleoplasm; transcription factor complex; PML body; nuclear chromatin; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; gamma-catenin binding; beta-catenin binding; chromatin binding; transcription factor binding; protein kinase binding; transcription factor activity; nuclear hormone receptor binding
Biological Process: skin development; fat cell differentiation; neural tube development; myoblast cell fate commitment; regulation of myelination; positive regulation of protein binding; somatic stem cell maintenance; positive regulation of apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; maintenance of DNA repeat elements; bone mineralization; negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; embryonic digestive tract morphogenesis; pancreas development; response to glucose stimulus; oligodendrocyte development; cell cycle arrest; embryonic genitalia morphogenesis; embryonic hindgut morphogenesis; blood vessel development; regulation of hormone metabolic process; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of insulin secretion; negative regulation of organ growth; negative regulation of fat cell differentiation; odontogenesis of dentine-containing teeth; regulation of transcription from RNA polymerase II promoter; positive regulation of protein kinase B signaling cascade; cell proliferation; pituitary gland development; generation of neurons; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; brain development; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; secretory granule localization
Reference #:  Q9NQB0 (UniProtKB)
Alt. Names/Synonyms: HMG box transcription factor 4; hTCF-4; T-cell factor 4; T-cell-specific transcription factor 4; TCF-4; TCF4; TCF7L2; TF7L2; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Symbols: TCF7L2
Molecular weight: 67,919 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCF7L2

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S177‑p
molecular association, regulation: T201‑p, T212‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S35-p EEKSSENsSAERDLA
0 1 S58-p ESETNQNsssDSEAE
0 1 S59-p SETNQNsssDSEAER
0 1 S60-p ETNQNsssDSEAERR
0 2 S79-p SESFRDKsREsLEEA
0 2 S82-p FRDKsREsLEEAAkR
0 1 K88-ub EsLEEAAkRQDGGLF
0 1 R126-m1 GSLSPTArTLHFQSG
0 1 Y151-p EHQIAVQyLQMKWPL
0 1 K155 AVQyLQMKWPLLDVQ
1 0 K173-ac LQSRQALkDARsPsP
1 3 S177-p QALkDARsPsPAHIV
0 4 S179-p LkDARsPsPAHIVSN
1 0 T201-p PHHVHPLtPLITYSN
1 0 T212-p TYSNEHFtPGNPPPH
1 0 K320 AIVTPTVKQESsQSD
0 1 S324-p PTVKQESsQSDVGSL
0 1 K335-ub VGSLHSSkHQDSKKE
0 1 K352-ub KKKPHIKkPLNAFML
0 1 K362-ac NAFMLYMkEMRAkVV
0 1 K367-ac YMkEMRAkVVAECTL
0 8 K398-ub LSREEQAkYYELARK
0 12 Y414-p RQLHMQLyPGWSARD
0 1 Y489-p RKKKCVRyIQGEGSC
0 1 K563-ac LLAEATHkASALCPN
  TCF7L2 iso4  
S35 EEKSSENSSAERDLA
S58 ESETNQNSSSDSEAE
S59 SETNQNSSSDSEAER
S60 ETNQNSSSDSEAERR
S79 SESFRDKSRESLEEA
S82 FRDKSRESLEEAAKR
K88 ESLEEAAKRQDGGLF
R126 GSLSPTARTLHFQSG
Y151 EHQIAVQYLQMKWPL
K155 AVQYLQMKWPLLDVQ
K173 LQSRQALKDARSPSP
S177 QALKDARSPSPAHIV
S179 LKDARSPSPAHIVSN
T201 PHHVHPLTPLITYSN
T212 TYSNEHFTPGNPPPH
K320 AIVTPTVKQESSQSD
S324 PTVKQESSQSDVGSL
K335 VGSLHSSKHQDSKKE
K352 KKKPHIKKPLNAFML
K362 NAFMLYMKEMRAKVV
K367 YMKEMRAKVVAECTL
K398 LSREEQAKYYELARK
Y414 RQLHMQLYPGWSARD
- gap
- gap
  TCF7L2 iso10  
S35 EEKSSENSSAERDLA
S58 ESETNQNSSSDSEAE
S59 SETNQNSSSDSEAER
S60 ETNQNSSSDSEAERR
S79 SESFRDKSRESLEEA
S82 FRDKSRESLEEAAKR
K88 ESLEEAAKRQDGGLF
R126 GSLSPTARTYLQMkW
Y128 LSPTARTYLQMkWPL
K132-ub ARTYLQMkWPLLDVQ
K150 LQSRQALKDARSPSP
S154 QALKDARSPSPAHIV
S156 LKDARSPSPAHIVSN
T178 PHHVHPLTPLITYSN
T189 TYSNEHFTPGNPPPH
K293 AIVTPTVKQESSQSD
S297 PTVKQESSQSDVGSL
K308 VGSLHSSKHQDSKKE
K325 KKKPHIKKPLNAFML
K335 NAFMLYMKEMRAKVV
K340 YMKEMRAKVVAECTL
K371 LSREEQAKYYELARK
Y387 RQLHMQLYPGWSARD
- gap
- gap
  mouse

 
S35 EEKNSENSSAERDLA
S58 ESETNQDSSSDSEAE
S59 SETNQDSSSDSEAER
S60 ETNQDSSSDSEAERR
S79 SESFRDKSRESLEEA
S82 FRDKSRESLEEAAKR
K88 ESLEEAAKRQDGGLF
R126 GSLSPTARTYLQMKW
Y128 LSPTARTYLQMKWPL
K132 ARTYLQMKWPLLDVQ
K150 LQSRQTLKDARSPsP
S154 QTLKDARSPsPAHIV
S156-p LKDARSPsPAHIVSN
T178 PHHVHPLTPLITYSN
T189 TYSNEHFTPGNPPPH
K297-sm AIVTPTVkQESSQSD
S301 PTVkQESSQSDVGSL
K312 VGSLHSSKHQDSKKE
K329 KKKPHIKKPLNAFML
K339 NAFMLYMKEMRAKVV
K344 YMKEMRAKVVAECTL
K375 LSREEQAKYYELARK
Y391 RQLHMQLYPGWSARD
- gap
- gap
  rat

 
S35 EEKNSENSSAERDLA
S58 ESETNQNSSSDSEAE
S59 SETNQNSSSDSEAER
S60 ETNQNSSSDSEAERR
S79 SESFRDKSRESLEEA
S82 FRDKSRESLEEAAKR
K88 ESLEEAAKRQDGGLF
R126 GSLSPTARTLHFQSG
Y151 EHQIAIQYLQMKWPL
K155 AIQYLQMKWPLLDVQ
K173 LQSRQALKDARsPsP
S177-p QALKDARsPsPAHIV
S179-p LKDARsPsPAHIVSN
T201 PHHVHPLTPLITYSN
T212 TYSNEHFTPGNPPPH
K320 AIVTPTVKQESSQSD
S324 PTVKQESSQSDVGSL
D335 VGSLHSSDLHEKKKP
K346 KKKPHIKKPLNAFML
K356 NAFMLYMKEMRAKVV
K361 YMKEMRAKVVAECTL
K392 LSREEQAKYYELARK
Y408 RQLHMQLYPGWSARD
Y466 RKKKCVRYIQGEGSC
K541 LAEAAHGKASALCPN
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