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TCF7L2
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Interacts with TGFB1I1. Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. Belongs to the TCF/LEF family. 10 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Transcription factor; DNA binding protein; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis |
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Cellular Component: nucleoplasm; transcription factor complex; PML body; nucleus
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Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; gamma-catenin binding; beta-catenin binding; chromatin binding; transcription factor binding; protein kinase binding; transcription factor activity; nuclear hormone receptor binding
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Biological Process: skin development; fat cell differentiation; neural tube development; myoblast cell fate commitment; regulation of myelination; positive regulation of protein binding; somatic stem cell maintenance; positive regulation of apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; maintenance of DNA repeat elements; bone mineralization; negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; embryonic digestive tract morphogenesis; pancreas development; response to glucose stimulus; cell cycle arrest; oligodendrocyte development; embryonic hindgut morphogenesis; embryonic genitalia morphogenesis; blood vessel development; regulation of hormone metabolic process; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of insulin secretion; negative regulation of organ growth; negative regulation of fat cell differentiation; odontogenesis of dentine-containing teeth; regulation of transcription from RNA polymerase II promoter; cell proliferation; positive regulation of protein kinase B signaling cascade; neurogenesis; pituitary gland development; generation of neurons; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; brain development; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; secretory granule localization
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Reference #:
Q9NQB0 (UniProtKB)
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| Alt. Names/Synonyms: HMG box transcription factor 4; hTCF-4; T-cell factor 4; T-cell-specific transcription factor 4; TCF-4; TCF4; TCF7L2; TF7L2; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box) |
| Gene Symbols: TCF7L2 |
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Molecular weight: 67,919 Da
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Basal Isoelectric point: 8.73
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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